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Epidemiology of Cervical Cancer

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Viral Infections of Humans

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Abstract

Carcinoma of the uterine cervix is one of the most common cancers in women in the United States and throughout the world. Because of its frequency and accessibility to methods of early detection, cervical cancer is among the most thoroughly studied of all human malignant diseases. Its natural history has been extensively investigated, and the gradation from intraepithelial neoplastic cervical changes (dysplasia and carcinoma in situ) to invasive carcinoma has been well documented. Although such progression of the disease does not appear to be an inevitable process, ample evidence has accumulated to indicate that when invasive cancer occurs it is practically always preceded by a preinvasive phase in its development.

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References

  1. Adam, E., Kaufman, R. H., Melnick, J. L., Levy, A. H., and Rawls, W. E., Seroepidemiologic studies of herpesvirus type 2 and carcinoma of the cervix. III.-Houston, Texas, Am. J. Epidemiol. 96: 427–442 (1972).

    PubMed  CAS  Google Scholar 

  2. Adam, E., Rawls, W. E., and Melnick, I. L., The association of herpesvirus type 2 infection and cervical cancer, Prev. Med. 3: 122–141 (1974).

    Article  PubMed  CAS  Google Scholar 

  3. Alexander, E. R., Possible etiologies of cancer of the cervix other than herpesvirus. Cancer Res. 33:1485–1496 (1973).

    Google Scholar 

  4. Aurelian, L., Royston, I., and Davis, H. I., Antibody to genital herpes simplex virus: Association with cervical atypia and carcinoma in situ, J. Natl. Cancer Inst. 45: 455–464 (1970).

    PubMed  CAS  Google Scholar 

  5. Aurelian, L., Virions and antigens of herpes virus type 2 in cervical carcinoma. Cancer Res. 33: 1539–1547 (1973).

    PubMed  CAS  Google Scholar 

  6. Aurelian, L., Strandberg, J. D., and Marcus, R. L., Neutralization, immunofluorescence and complement fixation tests in identification of antibody to a herpesvirus type 2-induced, tumor-specific antigen in sera from squamous cervical carcinoma: Immunology of cancer. Prog. Exp. Tumor Res. 19: 165–181 (1974).

    PubMed  CAS  Google Scholar 

  7. Baringer, J. R., and Swoveland, P., Recovery of herpes-simplex virus from human trigeminal ganglions, N. Engl. J. Med. 288: 648–650 (1973).

    Article  PubMed  CAS  Google Scholar 

  8. Baringer, J. R., Recovery of herpes simplex virus from human sacral ganglions, N. Engl. J. Med. 291: 828–830 (1974).

    Article  PubMed  CAS  Google Scholar 

  9. Bolten, K. A.. Practical colposcopy in early cervical and vaginal cancer, Clin. Obstet. Gynecol. 10(4):808–837 (1967).

    Google Scholar 

  10. Broders, A. C., Carcinoma in situ contrasted with benign penetrating epithelium, J. Am. Med. Assoc. 99: 1670–1674 (1932).

    Google Scholar 

  11. Catalano, L. W., Jr., and Johnson, L. D., Herpesvirus antibody and carcinoma in situ of the cervix, J. Am. Med. Assoc. 217: 447–450 (1971).

    Article  Google Scholar 

  12. Christopherson, W. M., Concepts of genesis and development in early cervical neoplasia. Obstet. Gynecol. Survey 24 (2): 842–850 (1969).

    Article  CAS  Google Scholar 

  13. Collard, W., Thornton, H., and Green, M., Cells transformed by human herpesvirus type 2 transcribe virus-specific RNA sequences shared by herpesvirus types 1 and 2, Nature (London) New Biol. 243: 264–266 (1973).

    CAS  Google Scholar 

  14. Coppleson, M., and Reid, B., Preclinical Carcinoma of the Cervix Uteri, Permagon Press, Oxford, 1967.

    Google Scholar 

  15. Disaia, P. J., Sinkovics, J. G., Rutledge, F. N., and Smith, J. P., Cell-mediated immunity to human malignant cells. Am. J. Obstet. Gynecol. 114: 979–989 (1972).

    PubMed  CAS  Google Scholar 

  16. Dueñas, A., Adam, E., Melnick, J. L., and Rawlo, W. E., Herpesvirus type 2 in a prostitute population. Am. J. Epidemiol. 95: 483–489 (1972).

    PubMed  Google Scholar 

  17. Franklin, E. W., Ill, and Rutledge, F. D., Epidemiology of epidermoid carcinoma of the vulva. Obstet. Gynecol. 39: 165–172 (1972).

    PubMed  Google Scholar 

  18. Freedman, R. S., Joosting, A.C.C., Ryan, J.T., and Nkoni, S., A study of associated factors, including genital herpes, in black women with cervical carcinoma in Johannesburg, S. Afr. Med. J. 48:1747–1752 (1974).

    Google Scholar 

  19. Frenkel, N., Roizman, B., Cassai, E., and Nahmias, A. À DNA fragment of herpes simplex 2 and its transcription in human cervical cancer tissue, Proc. Natl. Acad. Sci. USA 69: 3784–3789 (1972).

    Article  PubMed  CAS  Google Scholar 

  20. Fuccillo, D. A.. Sever, J. L., Moder, F. L., Chen, T. C., Catalano, L. W., and Johnson, L. D., Cytomegalovirus antibody in patients with carcinoma of the uterine cervix. Obstet. Gynecol. 38: 599–601 (1971).

    Google Scholar 

  21. Gusberg, S. B., and Frick, H. C., II, Corscaden’s Gyneccologic Cancer, 4th ed., Williams and Wilkins, Baltimore, 1970.

    Google Scholar 

  22. Hollinshead, A. C., and Tarro, G., Soluble membrane antigens of lip and cervical carcinomas: Reactivity with antibody for herpes-virus nonvirion antigens, Science 179: 698–700 (1973).

    Article  PubMed  CAS  Google Scholar 

  23. Hollinshead, A. C., Lee, O., Chretien, P. B., Tarpley, J. L., Rawls, W. E., and Adam, E., Antibodies to herpesvirus nonvirion antigens in squamous carcinomas, Science 182: 713–715 (1973).

    Article  PubMed  CAS  Google Scholar 

  24. Janda, Z., Kanda, J., Vonka, V., and Svoboda, B., A study of herpes simplex type 2 antibody status in groups of patients with cervical neoplasia in Czechoslovakia, Int. J. Cancer 12: 626–630 (1973).

    Article  PubMed  CAS  Google Scholar 

  25. Jeansson, S., and Molin, L., Prospective study of clinically detected genital herpes in Sweden, presented at the International Cancer Congress, Florence, Italy, 1974.

    Google Scholar 

  26. Johnson, L. D., The histopathological approach to early cervical neoplasia, Ohstet. Gynol. Survey. 24 (2): 735–767 (1969).

    Article  CAS  Google Scholar 

  27. Josey, W. E., Nahmias, A. J., and Z. M., Genital infection with type 2 herpesvirus hominis: Present knowledge and possible relation to cervical cancer. Am. J. Obstet. Gynecol 101: 718–729 (1968).

    Google Scholar 

  28. Kessler, I. I., Perspectives on the epidemiology of cervical cancer with special reference to the herpesvirus hypothesis. Cancer Res. 34: 1091–1110 (1974).

    PubMed  CAS  Google Scholar 

  29. Kimura, S., Flannery, V. L., Levy, B., and Schaffer, P. A., Oncogenic transformation of primary hamster cells by herpes simplex virus type 2 (HSV-2) and HSV-2 temperature sensitive mutant. Int. J. Cancer 15: 786–798 (1975).

    Article  PubMed  CAS  Google Scholar 

  30. Lilienfeld, A. M., Levine, M. L., and Kessler, I. I., Cancer in the United States, Harvard University Press, Cambridge, Mass., 1972.

    Google Scholar 

  31. Martinez, L, Relationship of squamous cell carcinoma of the cervix uteri to squamous cell carcinoma of the penis. Cancer 24: 777–780 (1969).

    Article  PubMed  CAS  Google Scholar 

  32. Mcdonald, A. D., Williams, M. C., Manfreda, J., and West, R., Neutralizing antibodies to herpesvirus types 1 and 2 in carcinoma of the cervix, carcinoma in situ and cervical dysplasia. Am. J. Epidemiol 100:130–135 (1974).

    Google Scholar 

  33. Melnick, J. L., and Rawls, W. E., Herpesvirus type 2 and cervical carcinoma, Ann. N.Y. Acad. Sci. 174:993–998 (1970).

    Google Scholar 

  34. Melnick, J. L., Adam, E., and Rawls, W. E., The causative role of herpesvirus type 2 in cervical cancer. Cancer 34: 1375–1385 (1974).

    Article  PubMed  Google Scholar 

  35. Munoz, N., Discussion on general aspects of cervical cancer. Cancer Res. 33: 1382–1384 (1973).

    Google Scholar 

  36. Munoz, N., Effect of herpesvirus type 2 and hormonal imbalance on the uterine cervix of the mouse. Cancer Res. 33: 1504–1508 (1973).

    PubMed  CAS  Google Scholar 

  37. Nahmias, A. J., and Dowdle, W. R., Antigenic and biologic differences in herpesvirus hominis. Prog. Med. Virol 10: 110–159 (1968).

    PubMed  CAS  Google Scholar 

  38. Nahmias, A. J., Josey, W. E., Naib, Z. M., Luce, C.F., and Guest, B. A., Antibodies to herpesvirus hominiss types 1 and 2 in humans. II. Women with cervical cancer. Am. J. Epidemiol 91: 547–552 (1970).

    PubMed  CAS  Google Scholar 

  39. Nahmias, A. J., Naib, Z. M., and Josey, W. E., Herpesvirus hominis type 2 infection—Association with cervical cancer and perinatal disease, Perspect. Virol 7: 73–89 (1970).

    Google Scholar 

  40. Nahmias, A. J., Naib, Z. M., Josey, W. E., Murphy, F. A., and Luce, C. F., Sarcomas after inoculation of newborn hamsters with herpesvirus hominis type 2 strains, Proc. Soc. Exp. Biol Med. 134: 1065–1069 (1970).

    PubMed  CAS  Google Scholar 

  41. Nahmias, A. J., Naib, Z. M., and Josey, W. E., Genital herpes and cervical cancer—can a causal relation be proven?—A review, in: Oncogenesis and Herpesviruses ( P. M. Biggs, G. De-The, and L. N. Payne, eds.). International Agency for Research on Cancer, Lyon, 1971.

    Google Scholar 

  42. Nahmias, A. J., London, W. T., and Catalano, L. W., Fuccielo, D.A., and Sever, J. L., Genital herpesvirus hominis type 2 infection: An experimental model in cebus monkeys. Science 171: 297–298 (1971).

    Article  PubMed  CAS  Google Scholar 

  43. Nahmias, A. J., Naib, Z. M., Josey, W. E., Franklin, E., and Jenkins, R., Prospective studies of the association of genital herpes simplex infection and cervical anaplasia. Cancer Res. 33: 1491–1497 (1973).

    PubMed  CAS  Google Scholar 

  44. Nahmias, A. J., The evolution (evovirology) of herpesviruses, in: Viruses, Evolution and Cancer (E. Kurstak and K. Maramorosch, eds.), pp. 605–624, Academic Press, New York, 1974.

    Google Scholar 

  45. Nahmias, A., Ibrahim, I., and Delbuono, I., Antigenic relation between herpes simplex viruses, human cervical cancer and HSV-associated hamster tumors, in: Herpesviruses and Oncogenesis, Vol. 2, in press, 1975.

    Google Scholar 

  46. Nahmias, A. J., Naib, Z. M., and Josey, W. E., Epidemiological studies relating genital herpetic infection to cervical carcinoma. Cancer Res. 34:1111–1117 (1974).

    Google Scholar 

  47. Naib, Z. M., Nahmias, A. J., and Josey, W. E., Cytology and histopathology of cervical herpes simplex infection. Cancer 19: 1026–1031 (1966).

    Article  PubMed  CAS  Google Scholar 

  48. Naib, Z. M., Nahmias, A. J., Josey, W. E., and Zaki, S. A., Relation of cytohistopathology of genital her-pesvirus infection to cervical analplasia. Cancer Res. 33: 1452–1463 (1973).

    PubMed  CAS  Google Scholar 

  49. Nalick, R. H., Disaia, P. J., Rea, T. H., and Morrow, M. H., Immunological response in gynecologic malignancy as demonstrated by the delayed hypersensitivity reaction: Clinical correlations. Am. J. Obstet. Gynecol 118: 393–405 (1974).

    PubMed  CAS  Google Scholar 

  50. Nelson, J. H., Jr., and Hall, J. E., Detection, diagnostic evaluation, and treatment of dysplasia and early carcinoma of the cervix, Ca.—Cancer J. Physicians 20: 150–163 (1970).

    Article  Google Scholar 

  51. Ory, H., Conger, B., Richart, R., and Barron, B., Relation of type 2 herpesvirus antibodies to cervical neoplasia in Barbados, West Indies, 1971, Obstet. Gynecol 43: 901–904 (1974).

    PubMed  CAS  Google Scholar 

  52. Papanicolaou, G. N., and Traut, H. Diagnosis of Uterine Cancer by the Vaginal Smear, Commonwealth Fund, New York, 1943.

    Google Scholar 

  53. Plummer, G., Serological comparison of the herpesviruses, Br. J. Exp. Pathol 45: 135–141 (1964).

    PubMed  CAS  Google Scholar 

  54. Plummer, G., A review of the identification and titration of antibodies to herpes simplex viruses type 1 and type 2 in human sera. Cancer Res. 33: 1469–1476 (1973).

    PubMed  CAS  Google Scholar 

  55. Pund, E. R., and Auerbach, S. H., Preinvasive carcinoma of the cervix uteri, J. Am. Med. Assoc. 131:960–963 (1946).

    Google Scholar 

  56. Rapp, F., and Duff, R., Transformation of hamster embryo fibroblasts by herpes simplex viruses type 1 and type 2, Cancer Res. 33: 1527–1534 (1973).

    PubMed  CAS  Google Scholar 

  57. Rapp, F., Herpesviruses and cancer. Adv. Cancer Res. 19: 265–302 (1974).

    Article  PubMed  CAS  Google Scholar 

  58. Rawls, W. E., Tompkins, W. A. F., and Melnick, J. L., The association of herpesvirus type 2 and carcinoma of the uterine cervix. Am. J. Epidemiol 89:547–554 (1969).

    Google Scholar 

  59. Rawls, W. E., Adam, E., and Melnick, J. L., An analysis of seroepidemiological studies of herpesvirus type 2 and carcinoma of the cervix. Cancer Res. 33: 1477–1482 (1973).

    PubMed  CAS  Google Scholar 

  60. Reagan, J. W., and Wentz, W. B., Genesis of carcinoma of the uterine cervix, Clin. Obstet. Gynecol 10 (4): 883–921 (1967).

    Article  PubMed  CAS  Google Scholar 

  61. Richart, R. M., Natural history of cervical intraepithelial neoplasia, Clin. Obstet. Gynecol 10 (4): 748–784 (1967).

    Article  Google Scholar 

  62. Rigoni-Stern, D., Fatti statistici relativi alle malattie cancrose che servirono di base alle poche cose dette dal Dott. G. Servire, Prog. Pathol Terap. Ser. 2:507–517 (1842).

    Google Scholar 

  63. Roeman, B., and Furlong, D., The replication of herpesviruses in: Comprehensive Virology, Vol. 3 (H. Fraenkel-Conrat and R. R. Wagner, eds.), pp. 229–403, Plenum, New York, 1974.

    Google Scholar 

  64. Rotkin, I. D., A comparison review of key epidemiological studies in cervical cancer related to current searches for transmissible agents. Cancer Res. 33: 1353–1367 (1973).

    PubMed  CAS  Google Scholar 

  65. Sabin, A. B., and Tarro, G., Herpes simplex and herpes genitalis viruses in etiology of some human cancers, Proc. Natl Acad. Sci. USA 70: 3225–3229 (1973).

    Article  PubMed  CAS  Google Scholar 

  66. Sabin, A. B., Herpes simplex-genitalis virus non-virion antigens and their implication in certain human cancers: Unconfirmed, Proc. Natl Acad. Sci. Usa 71: 3248–3253 (1974).

    Article  PubMed  CAS  Google Scholar 

  67. Schneweis, K. E., Serologische Untersuchungen zur Typendifferenzierung des Herpesvirus hominis, Z. Immunitaetsforsch. 124: 24–48 (1962).

    PubMed  CAS  Google Scholar 

  68. Seth, P., Rawls, W. E., Duff, R., Rapp, F., Adam, E., and Melnick, J. L., Antigenic differences between isolates of herpesvirus type 2, Intervirology 3: 1–14 (1974).

    Article  PubMed  CAS  Google Scholar 

  69. Sprecher-Goldberger, S., Thiry, L., Lefebvre, N., Dekegel, D., and Dehalleux, F., Complement-fixation antibodies to adenovirus-associated viruses, adenoviruses, cytomegaloviruses and herpes simplex viruses in patients with tumors and in control individuals. Am. J. Epidemiol 94: 351–358 (1971).

    PubMed  CAS  Google Scholar 

  70. Sprecher-Goldberger, S., Thiry, L., Gould, I., Fassin, Y., and Compel, C., Increasing antibody titers to herpes simplex virus type 2 during follow-up of women with cervical dysplasia. Am. J. Epidemiol 97: 103–110 (1973).

    PubMed  CAS  Google Scholar 

  71. Spjut, H. J., and Fechner, R. E., Cytologic diagnosis of cervical dysplasia and carcinoma in situ, Clin. Obstet. Gynecol 10 (4): 785–807 (1967).

    Article  PubMed  CAS  Google Scholar 

  72. Stafl, A., Friedrich, E. G., and Mattingly, R. F., Detection of cervical neoplasia: Reducing the risk of error. Ca.—Cancer J. Physicians 24 (l): 22–30 (1974).

    Article  CAS  Google Scholar 

  73. Thiry, L., Sprecher-Goldberger, S., Fassin, Y., Gould, I., Compel, C., Pestiau, J., and Dehalleux, F., Variations of cytotoxic antibodies to cells with herpes simplex virus antigens in women with progressing or regressing cancerous lesions of the cervix. Am. J. Epidemiol 100: 251–261 (1974).

    PubMed  CAS  Google Scholar 

  74. Vestergaard, B. F., Hornsleth, A., and Pedersen, S. N., Occurrence of herpes and adenovirus antibodies in patients with carcinoma of the cervix uteri. Cancer 30: 68–74 (1972).

    Article  PubMed  CAS  Google Scholar 

  75. Weintraub, I., Klisak, I., Lagasse, L. D., and Byfield, J. E., Evidence for specific tumor cytotoxic antibodies in serum of cervical cancer patients. Am. J. Obstet. Gynecol 116: 985–992 (1973).

    PubMed  CAS  Google Scholar 

  76. Wynder, E. L., Epidemiology of carcinoma in situ of the cervix, Obstet. Gynecol Survey 24 (2): 697–711 (1969).

    Article  CAS  Google Scholar 

  77. Zur Hausen, J., Schulte-Holthausen, H., Wolf, H., Dorries, K., and Egger, H., Attempts to detect virus-specific DNA in human tumors. II. Nucleic acid hybridizations with complementary RNA of human herpes group viruses. Int. J. Cancer 13: 657–664 (1974).

    Article  PubMed  Google Scholar 

Suggested Reading

  • Conference on Early Cervical Neoplasia, Obstet. Gynecol Survey 24(2):675–1048 (1969).

    Google Scholar 

  • Coppleson, M., and Reid, B., Preclinical Carcinoma of the Cervix uteri, Pergamon Press, Oxford, 1967.

    Google Scholar 

  • Clin. Obstet. Gynecol. 10(4):741–1049 (1967).

    Google Scholar 

  • Levine, P. H., Gaylord, C. E., and Burton, G. J., eds.. International Symposium on Human Tumors Associated with Herpesviruses, Cancer Res. 34:1083–1244 (1974).

    Google Scholar 

  • Symposium on Herpesvirus and Cervical Cancer, Cancer Res. 33: 1345–1563 (1973).

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA

    André J. Nahmias, William E. Josey & James M. Oleske

  2. Department of Gynecology, Emory University School of Medicine, Atlanta, Georgia, USA

    André J. Nahmias, William E. Josey & James M. Oleske

  3. Department of Obstetrics, Emory University School of Medicine, Atlanta, Georgia, USA

    André J. Nahmias, William E. Josey & James M. Oleske

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  1. André J. Nahmias
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  2. William E. Josey
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  3. James M. Oleske
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Editors and Affiliations

  1. Yale University, USA

    Alfred S. Evans

  2. WHO Serum Reference Bank, Section of International Epidemiology, New Haven, Connecticut, USA

    Alfred S. Evans

  3. Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA

    Alfred S. Evans

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© 1976 Plenum Publishing Corporation

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Nahmias, A.J., Josey, W.E., Oleske, J.M. (1976). Epidemiology of Cervical Cancer. In: Evans, A.S. (eds) Viral Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3988-5_23

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