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Viral Infections of Humans pp 457–480Cite as

Varicella-Herpes Zoster Virus

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Abstract

Varicella-zoster virus (Herpesvirus varicellae), commonly abbreviated to “V-Z virus” is the etiological agent of two diseases of man, varicella and herpes zoster. Varicella (chickenpox) is a ubiquitous, contagious, generalized exanthematous disease of seasonally epidemic propensities that follows primary exposure of a susceptible individual, most often a child. Herpes zoster (shingles) is an endemic sporadic disease, most frequent in elderly people, characterized by the appearance of a unilateral, painful, vesicular eruption localized to the dermatome innervated by a specific dorsal root or extramedullary cranial ganglion. In contrast to varicella, which follows primary exogenous contact with the causative virus, zoster reflects endogenous activation of a V-Z viral infection that has survived in latent form following an attack of varicella. The two clinical entities are not as distinct as is customarily assumed. The patient with zoster frequently develops a disseminated varicelliform eruption; rarely the individual with varicella may exhibit a zosteriform concentration of lesions.

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Authors and Affiliations

  1. Department of Tropical Public Health, Harvard School of Public Health, Boston, Massachusetts, USA

    Thomas H. Weller (Richard Pearson Strong Professor of Tropical Public Health and Head, Director)

  2. Center for Prevention of Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA

    Thomas H. Weller (Richard Pearson Strong Professor of Tropical Public Health and Head, Director)

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  1. Yale University, USA

    Alfred S. Evans

  2. WHO Serum Reference Bank, Section of International Epidemiology, New Haven, Connecticut, USA

    Alfred S. Evans

  3. Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA

    Alfred S. Evans

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Weller, T.H. (1976). Varicella-Herpes Zoster Virus. In: Evans, A.S. (eds) Viral Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3988-5_21

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