Some Molecular Aspects of Neural Mechanisms

  • J. R. Smythies

Abstract

This contribution to the volume of scientific papers in memory of my old teacher Harold Himwich will review seven years’ work in a field that might variously be regarded as structural molecular biology or else as neuroanatomy at the molecular level. The strategy that I have used to guide my approach to these problems has been based on my training as a neuroanatomist. The majority of workers currently in molecular neurobiology have reached it via biochemistry or biophysics, and hence functional relationships have been to the fore in their work, whereas structural aspects of molecular neural mechanisms, as the ultimate basis of all behavior, are equally important.

Keywords

Thymine Tetrodotoxin Strychnine Thebaine Saxitoxin 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barlow, R. B., 1964, Introduction to Chemical Pharmacology, Methuen, London.Google Scholar
  2. Catterall, W. A., 1975, Activation of the action potential Na+ ionophore of cultured neuroblastoma cells by veratridine and batrachotoxin, J. Biol. Chem. 250:4053.PubMedGoogle Scholar
  3. Collins, J. F., Hill, R. G., and Roberts, F., 1975, A study of tetramethylenedisulphotetramine (TETS) and related compounds as antagonists of presynaptic inhibition and microiontophoretically applied γ-aminobutyric acid (GABA) and glycine in the rat cuneate nucleus, Br. J. Pharmacol. 54:239P.Google Scholar
  4. Crick, F. H. C., and Klug, A., 1975, Kinky helix, Nature (London) 255:530.CrossRefGoogle Scholar
  5. Curtis, D. R., and Johnston, G. A. R., 1974, Convulsant alkaloids, in: Neuropoisons, Vol. 2 (L. L. Simpson and D. R. Curtis, eds.), pp. 207–248, Plenum, New York.Google Scholar
  6. DeLange, R. J., Famborough, D. M., Smith, E. L., and Bonner, J., 1969, Calf and pea histone IV. III. Complete amino acid sequence of pea seedling histone IV; comparison with the homologous calf thymus histone, J. Biol. Chem. 244:5669.PubMedGoogle Scholar
  7. DeLange, R. J., Hooper, J. A., and Smith, E. L., 1972, Complete amino acid sequence of calf thymus histone III, Proc. Natl. Acad. Sci. U.S.A. 69:882.PubMedCrossRefGoogle Scholar
  8. Dray, A., 1975, Tetramethylenedisulphotetramine and amino acid inhibition in the rat brain, Neuropharmacology 14:703.PubMedCrossRefGoogle Scholar
  9. Eccles, J. R., 1970, Facing Reality, Springer-Verlag, New York.Google Scholar
  10. Fasman, G., Chou, P. Y., and Adler, A. J., 1976, Prediction of the conformation of the histones, Biophys. J. 16:1201.PubMedCrossRefGoogle Scholar
  11. Gill, E. W., 1965, Drug receptor interactions, Prog. Med. Chem. 4:39.PubMedCrossRefGoogle Scholar
  12. Hille, G., 1971, The permeability of the sodium channel to organic cations in myelinated nerve, J. Gen. Physiol. 58:599.PubMedCrossRefGoogle Scholar
  13. Iwai, K., Ishikawa, K., and Hayashi, H., 1970, Amino acid sequence of slightly lysine rich histone, Nature (London) 226:1056.CrossRefGoogle Scholar
  14. Kolata, G. B., 1975, Chromatin structure: The supercoil is superseded, Science 188:1097.PubMedCrossRefGoogle Scholar
  15. Kusnetsov, S. G., and Ghokov, S. N., 1962, Synthetic Atropine-like Substances, State Publishing House of Medical Literature, Leningrad.Google Scholar
  16. Olins, D. E., and Olins, A. L., 1974, Spheroid chromatin units (v bodies), Science 183:330.PubMedCrossRefGoogle Scholar
  17. Smythies, J. R., 1974, Relationships between chemical structure and biological activity of convulsants, Annu. Rev. Pharmacol. 14:9.CrossRefGoogle Scholar
  18. Smythies, J. R., 1975a, The molecular structure of acetylcholine and adrenergic receptors: An all protein model, Int. Rev. Neurobiol. 17:131.PubMedCrossRefGoogle Scholar
  19. Smythies, J. R., 1975b, Possible molecular forms of the opiate receptor, Life Sci. 16:1819.PubMedCrossRefGoogle Scholar
  20. Smythies, J. R., 1975c, The molecular structure of the sodium channel, in: Molecular and Quantum Chemistry (E. Bergmann and B. Pullman, eds)., pp. 573–581, Reidel, Boston.Google Scholar
  21. Smythies, J. R., 1977, On the molecular structure of the opiate receptor, Psychoneuroendocrìnology 2:71.PubMedCrossRefGoogle Scholar
  22. Smythies, J. R., Antun, F., Yank, G. O., and York, C., 1971, Molecular mechanisms of storage of transmitters in synaptic terminals, Nature (London) 231:185.CrossRefGoogle Scholar
  23. Smythies, J. R., Benington, F., and Morin, R. D., 1972, A mechanism for the interaction of a histone and DNA, J. Theor. Biol. 37:151.PubMedCrossRefGoogle Scholar
  24. Smythies, J. R., Benington, F., Bradley, R. J., Morin, R. D., and Romine, W. O., Jr., 1974a, On the mechanism of interaction between histone I and DNA and histone III and DNA, J. Theor. Biol. 47:309.PubMedCrossRefGoogle Scholar
  25. Smythies, J. R., Benington, F., Bradley, R. J., Morin, R. D., and Romine, W. O., Jr., 1974b, On the mechanism of interaction between histone IIB1 and DNA and histone IIB2 and DNA, J. Theor. Biol. 47:383.PubMedCrossRefGoogle Scholar
  26. Smythies, J. R., Benington, F., and Morin, R. D., 1975a, On the molecular structure of receptors for co-carcinogens and some anti-cancer drugs, Psychoneuroendocrinology 1:20.Google Scholar
  27. Smythies, J. R., Benington, F., Bridgers, W. F., Bradley, R. J., Morin, R. D., and Romine, W. O., Jr., 1975b, The molecular structure of the receptor-ionophore complex at the neuromuscular junction, J. Theor. Biol. 51:111.PubMedCrossRefGoogle Scholar
  28. Smythies, J. R., Benington, F., Bradley, R. J., and Morin, R. D., 1977, A molecular mechanism of action of scorpion neurotoxins, Ala. J. Med. Sci. 14:68.PubMedGoogle Scholar
  29. Weintraub, H., Worcel, A., and Alberts, B., 1976, A model for chromatin based on two symmetrically paired half-nucleosomes, Cell 9:409.PubMedCrossRefGoogle Scholar
  30. Yeoman, L. C., Olson, M. O., Sugano, N., Jordan, J. J., Taylor, C. W., Starbuck, W. C., and Busch, H., 1972, Amino acid sequence of the center of the arginine-lysine-rich histone from calf thymus: The total sequence, J. Biol. Chem. 247:6018.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1978

Authors and Affiliations

  • J. R. Smythies
    • 1
  1. 1.Department of Psychiatry and the Neurosciences ProgramUniversity of Alabama in BirminghamBirminghamUSA

Personalised recommendations