Abstract
One of the most recent reviews of selected papers on diphenyl-hydantoin (DPH) lists 1712 references (Dreyfus Medical Foundation, 1975). Yet, most of the papers have as an opening remark: “Although DPH is the most widely used anticonvulsant, its mechanism of action is still unknown.”
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Anderson, R. J., and Raines, A., 1974a, Selective diphenylhydantoin suppression of auditory evoked potentials in the cat cerebellar cortex, Neuropharmacology 13:749–754.
Anderson, R. J., and Raines, A., 1974b, Suppression by diphenylhydantoin of afferent discharges arising in muscle spindles of the triceps surae of the cat, J. Pharmacol. Exp. Ther. 191:290–299.
Anderson, R. J., and Raines, A., 1975, Suppression of cerebellar evoked potentials by peripheral action of diphenylhydantoin, Arch. Int. Pharmacodyn. Ther. 68:549–554.
Ayala, G. F., Dichter, H., Gumnit, R. J., Matsumoto, H., and Spencer, W. A., 1973, Genesis of epileptic interictal spikes. New knowledge of cortical feedback systems suggests a neurophysiological explanation of brief paroxysms, Brain Res. 52:1–18.
Ayala, G. F., Lin, S., and Johnston, D., 1977a, The mechanism of action of diphenylhydantoin on invertebrate neurons. I. Effects on basic membrane properties, Brain Res. 121:245–258.
Ayala, G. F., Johnston, D., Lin, S., and Dichter, H. N., 1977b, The mechanism of action of diphenylhydantoin on invertebrate neurons. II. Effects on synaptic mechanisms, Brain Res. 121:259–270.
Barker, J. L., and Gainer, H., 1973, Pentobarbital: Selective depression of excitatory synaptic potentials, Science 182: 720–722.
Barker, J. L., and Gainer, H., 1975, Studies on bursting pacemaker potential activity in molluscan neurons. II. Regulation by divalent cations, Brain Res. 84:479–500.
Baskin, S. I., Dutta, S., and Marks, B. H., 1973, The effects of diphenylhydantoin and potassium on the biological activity of ouabain in the guinea-pig heart, Br. J. Pharmacol. 47:85–96.
Bittar, E. E., Chen, S. S., Danielson, B. A., and Tong, E. Y., 1973, An investigation of the action of diphenylhydantoin on sodium efflux in barnacle muscle fibres, Acta Physiol. Scand. 89:30–38.
Camay, L., and Grundfest, S., 1974, Excitable membrane stabilization by diphenylhydantoin and calcium, Neuropharmacology 13:1097–1108.
Carpenter, D. O., and Alvin, B. O., 1968, A contribution of an electrogenic Na+ pump to membrane potential in Aplysia neurons, J. Gen. Physiol. 52:1–21.
Carroll, P. T., and Pratley, J. N., 1970, The effects of diphenylhydantoin on sodium transport in frog skin, Com. Gen. Pharmacol. 1:365.
David, R. J., Wilson, W. A., and Escueta, A. V., 1974, Voltage clamp analysis of pentylenetetrazol effects on Aplysia neurons, Brain Res. 67:549–554.
Den Hertog, A., 1972, The effect of diphenylhydantoin on the electrogenic component of the sodium pump in mammalian nonmyelinated nerve fibres, Eur. J. Pharmacol. 19:94–97.
de Sousa, R. C., and Grosso, A., 1973, Interaction of diphenylhydantoin with norepinephrine, theophilline and cyclic AMP in frog skin, Experientia 29:748–749.
Deupree, J. D., 1976, Evidence that diphenylhydantoin does not affect adenosine triphosphatases from brain, Neuropharmacology 15:187–195.
Dreyfus Medical Foundation, 1975, DPH.
Escueta, A. V., and Appel, S. H., 1971, Diphenylhydantoin and potassium transport in isolated nerve terminals, J. Clin. Invest. 150:9–15.
Escueta, A. V., Davidson, D., Hartwing, G., and Reilly, E., 1974, The freezing lesion. III. The effects of diphenylhydantoin on potassium transport within nerve terminals from the primary foci, Brain Res. 86:85–96.
Esplin, D., 1957, Effect of diphenylhydantoin on synaptic transmission in the cat spinal cord and stellate ganglion, J. Pharmacol. Exp. Ther. 120:301–323.
Fertziger, A. P., Liuzzi, S. E., and Dunham, P. B., 1971 Diphenylhydantoin (Dilantin): Stimulation of potassium influx in lobster axons, Brain Res. 33:592–596.
Festoff, B. W., and Appel, S. H., 1968, Effect of diphenylhydantoin on synaptosome sodium potassium ATPase, J. Clin. Invest. 47:2752–2758.
Frazier, W. T., Kandel, E. R., Kupfermann, I., Waziri, R., and Coggeshall, R. E., 1967, Morphological and functional properties of identified neurons in the abdominal ganglion of Aplysia California, J. Neurophysiol. 30:1288–1351.
Gibson, K., and Harris, P., 1969, Diphenylhydantoin and human myocardial microsomal (Na+, K+)-ATPase, Biochem. Biophys. Res. Commun. 35:75–78.
Godfraind, T., Lesne, M., and Pousti, A., 1971, The action of diphenylhydantoin upon drug binding ionic effects and inotropic action of ouabain, Arch. Int. Pharmacodyn. Ther. 191:66–73.
Halpem, L. M., and Julien, R. M., 1972, Augmentation of cerebellar Purkinje cell discharge rate after diphenylhydantoin, Epilepsia 13:377–385.
Hasbani, M., Pincus, J., and Lee, S. H., 1974, Diphenylhydantoin and calcium movement in lobster nerves, Arch. Neurol. 31:250–254.
Heinemann, V., and Lux, H. D., 1973, Effects of diphenylhydantoin on extracellular (K+) in cat cortex, Electroencephalogr. Clin. Neurophysiol. 34:735.
Johnston, D., 1976, Voltage clamp reveals basis for calcium regulation of bursting pacemaker cells in Aplysia, Brain Res. 107:418–423.
Johnston, D., and Ayala, G. F., 1975, Diphenylhydantoin: The action of a common anticonvulsant on bursting pacemaker cells in Aplysia, Science 189:1009–1011.
Kao, L. J., and Crill, W. E., 1972a, Penicillin induced segmental myoclonus. I. Motor responses and intracellular recording from motor neurons, Arch. Neurol. 26:150–161.
Kao, L. J., and Crill, W. E., 1972b, Penicillin induced segmental myoclonus. II. Membrane properties of cat spinal motoneurons, Arch. Neurol. 26:162–168.
Kehoe, J. A., 1972, Ionic mechanisms of a two component cholinergic inhibition in Aplysia neurons, J. Physiol. 225:85–114.
Korey, S. R., 1951, Effect of Dilantin and Mesatoin on the giant axon of the squid, Proc. Soc. Exp. Biol. Med. 79:297–299.
Lipicky, R. J., Gilbert, D. L., and Stillman, I. M., 1972, diphenylhydantoin inhibition of sodium conductance in squid giant axon, Proc. Nad. Acad. Sci. U.S.A. 69:1758–1760.
Lux, M. D., 1974, The kinetics of extracellular potassium: Relation to epileptogenesis, Epilepsia 15:375–394.
Meech, R. W., and Standen, N. B., 1975, Potassium activation in Helix aspersa neurones under voltage clamp: A component mediated by calcium influx, J. Physiol. 249:211–239.
Nakajima, S., and Takahashi, K., 1966, Post-tetanic hyperpolarization and electrogenic Na pump in stretch receptor neurone of crayfish, J. Physiol. 187:105–127.
O’Donnell, J. J., Tikovacs, B., and Szabo, S., 1975, Influence of membrane stabilizer diphenylhydantoin on potassium and sodium movements in skeletal muscle, Pfluegers Arch. 358:275–288.
Ozawa, S., and Tsuda, K., 1973, Membrane permeability change during inhibitory transmitter action in crayfish stretch receptor cell, J. Neurophysiol. 36:805–816.
Pincus, J. H., 1972, diphenylhydantoin and ion flux in lobster nerves, Arch. Neurol. 26:4–10.
Pincus, J. H., and Giarman, N. H., 1967, The effect of diphenylhydantoin on sodium, potassium, and magnesium stimulated adenosine triphosphatase activity of rat brain, Biochem. Pharmacol. 16:600–603.
Pincus, J. H., and Lee, S. H., 1973, diphenylhydantoin and calcium, Arch. Neurol. 29:239–244.
Pincus, J. H., and Rawson, M. D., 1969, diphenylhydantoin and intracellular sodium concentration, Neurology 19:419–422.
Pincus, J. H., Grove, I., Marino, B. B., and Glasser, G. E., 1970, Studies on the mechanism of action of diphenylhydantoin, Arch. Neurol. 22:566–571.
Puro, D. G., and Woodward, D. J., 1973, Effects of diphenylhydantoin on activity of rat cerebellar Purkinje cells, Neuropharmacology 12:433–440.
Raabe, W., and Ayala, G. F., 1976, diphenylhydantoin increases cortical postysynaptic inhibition, Brain Res. 105:597–601.
Raines, A., and Standaert F. G., 1967, An effect of diphenylhydantoin on post-tetanic hyperpolarization of intramedullary nerve terminals, J. Pharmacol. Exp. Ther. 156:591–597.
Rawson, M. D., and Pincus, J. H., 1968, The effect of diphenylhydantoin on sodium, potassium, magnesium-activated adenosine triphospharte in microsomal fractions of rat and guinea-pig brain and on whole homogenates of human brain, Biochem. Pharmacol. 17:573–579.
Riddle, T. R., Mandel, L. J., and Goldner, M. M., 1975, Dilantin-calcium interaction and active Na transport in frog skin, Eur. J. Pharmacol. 33:49–192.
Spain, R., and Chidsey, B. A., 1971, Myocardial Na/K adenosine triphosphatase activity during reversal of ouabain toxicity with diphenylhydantoin, J. Pharmacol. Exp. Ther. 779:594–598.
Strittmatter, W. J., and Somjen, G. G., 1973, Depression of sustained evoked potential and glial depolarization in spinal cord by barbiturates and by diphenylhydantoin, Brain Res. 55:333–342.
Su, P. C., and Feldman, D. S., 1973, Motor nerve terminal and muscle membrane stabilization by diphenylhydantoin administration, Arch. Neurol. 28:376–779.
Watson, E. L., and Woodbury, D. M., 1972, Effects of diphenylhydantoin on active sodium transport in frog skin, J. Pharmacol. Exp. Ther. 180:767–782.
Watson, E. L., and Woodbury, D. M., 1973, The effect of diphenylhydantoin and ouabain, alone and in combination, in the electrocardiogram and on cellular electrolytes of guineapig heart and skeletal muscle, Arch. Int. Pharmacodyn. Ther. 201:389–399.
Weinreich, D., 1971, Ionic mechanism of post-tetanic potentiation at the neuromuscular junction of the frog, J. Physiol 212:431–446.
Whisler, J. W., and Johnston, D., 1975, Diphenylhydantoin and calcium on Aplysia neurons, 5th Annual Meeting of the Society of Neuroscience, Toronto, abstract 1106.
Woodbury, D. M. 1955, Effect of diphenylhydantoin on electrolytes and radiosodium turnover in brain and other tissues of normal, hyponatremic and postictal rats, J. Pharmacol. Exp. Ther. 115:74–95.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1978 Plenum Press, New York
About this chapter
Cite this chapter
Ayala, G.F., Johnston, D. (1978). The Neurophysiological Effects of Diphenylhydantoin and Their Relationship to Anticonvulsant Activity. In: Haber, B., Aprison, M.H. (eds) Neuropharmacology and Behavior. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3961-8_6
Download citation
DOI: https://doi.org/10.1007/978-1-4613-3961-8_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3963-2
Online ISBN: 978-1-4613-3961-8
eBook Packages: Springer Book Archive