Abstract
Axelrod and colleagues (Axelrod, 1971; Thoenen, et al, 1969) reported that in rat adrenal medulla, the activity of tyrosine-3-monooxygenase (TH) can be regulated transsynaptically. They found that medullary TH activity increases after the injection of nicotinic receptor agonists or when the activity of cholinergic neurons innervating the medula increases. These changes in TH occur several hours after the stimulus, and depend on RNA transcription (Chuang and Costa, 1976) and protein synthesis (Axelrod, 1971). With the exception of the injection of nicotinic receptor agonists, however, all the other stimuli failed to increase TH activity when applied after adrenal denervation; therefore, this increase, of TH was termed “transsynaptic induction.” Furthermore, the possibility that the increase in TH was an enzyme induction was corroborated in independent studies carried out in S. Kaufman’s (Hoeldtke et al, 1974) and D. Reis’s (Joh et al, 1973) laboratories. Using immunotitration experiments, they showed that in adrenal, the number of TH molecules increases during transsynaptic induction. These immunotitration experiments do not prove, however, that the transsynaptic induction of TH involves a change in gene expression leading to an increased transcription of the mRNA coding TH synthesis.
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Guidotti, A., Costa, E. (1978). The Induction of Tyrosine-3-monooxygenase in Rat Adrenal Medulla: A Model for the Transsynaptic Regulation of Gene Expression. In: Haber, B., Aprison, M.H. (eds) Neuropharmacology and Behavior. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3961-8_5
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