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Neuropharmacology and Behavior pp 55–87Cite as

The Organization of Central Catecholamine Neuron Systems

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Abstract

In the late 1900’s, three phenomena gave great impetus to the study of the morphology of the nervous system: first, the evolution of the neuron doctrine; second, the development of powerful techniques for the analysis of neural structure; third, the prominence of the concept of localization of function. A natural consequence of the development of the neuron doctrine was the concept of the synapse, which, in turn, required that some mechanism be established by which information is transmitted from one nerve cell to another or from a nerve cell to an effector cell. The history of the development of the concept of chemical transmission at the synapse is too well known to be recounted here. Of particular importance for this review was the establishment of noradrenaline as the sympathetic neurotransmitter by von Euler (1946). This was followed by the landmark work of Vogt (1954) demonstrating that noradrenaline and adrenaline are present in brain with a distinct regional distribution that is independent of the sympathetic innervation of the CNS. Numerous subsequent studies have refined these observations, but it was not until the development of a specific and sensitive histochemical method for the intracellular demonstration of catecholamines (Falck et al, 1962; Falck, 1962; Carlsson et al, 1962; for a review, cf. Corrodi and Jonsson, 1967) that a precise analysis of central catecholarnine (CA) neuron systems could be carried out.

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Authors and Affiliations

  1. Department of Neurosciences, University of California at San Diego, 92092, La Jolla, California, USA

    Robert Y. Moore & Lawrence F. Kromer

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  1. Robert Y. Moore
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  2. Lawrence F. Kromer
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Editors and Affiliations

  1. The Marine Biomedical Institute Department of Human Biological Chemistry and Genetics and Department of Neurology, University of Texas Medical Branch, Galveston, Texas, USA

    Bernard Haber

  2. Institute of Psychiatric Research and Departments of Psychiatry and Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana, USA

    M. H. Aprison

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© 1978 Plenum Press, New York

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Moore, R.Y., Kromer, L.F. (1978). The Organization of Central Catecholamine Neuron Systems. In: Haber, B., Aprison, M.H. (eds) Neuropharmacology and Behavior. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3961-8_3

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  • DOI: https://doi.org/10.1007/978-1-4613-3961-8_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3963-2

  • Online ISBN: 978-1-4613-3961-8

  • eBook Packages: Springer Book Archive

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