Skip to main content
SpringerLink
Log in

Adenosine in the Regulation of Neurotransmitter Release in the Peripheral Nervous System

  • Chapter
Regulatory Function of Adenosine

Part of the book series: Developments in Pharmacology ((DIPH,volume 2))

Abstract

About ten years ago, Ginsborg and Hirst [1] found that adenosine reduced the quantum content and the frequency of miniature end-plate potentials in the rat phrenic nerve-diaphragm preparation. The effect of adenosine was partly calcium-dependent and inhibited by theophylline. These findings clearly suggested that adenosine acted on presynaptic receptors to depress the release of acetylcholine from cholinergic nerves. Subsequently, it was shown that adenine nucleotides acted in a similar manner as adenosine and that these compounds depressed the release of several types of transmitters in many tissues, as reviewed elsewhere [2–4].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ginsborg BL, Hirst GDS: The effect of adenosine on the release of the transmitter from the phrenic nerve of the rat. J Physiol (Lond) 224: 629–645, 1972.

    CAS  Google Scholar 

  2. Fredholm BB, Hedqvist P: Modulation of neurotransmission by purine nucleotides and nuc1eosides. Biochem Pharmacol 29: 1635–1643, 1980.

    Article  PubMed  CAS  Google Scholar 

  3. Paton DM: Presynaptic neuromodulation mediated by purinergic receptors, in Burnstock G (ed): Purinergic Receptors. London, Chapman and Hall, 1981, pp 199–220.

    Google Scholar 

  4. Gustafsson L, Hedqvist P, Fredholm BB: Release and presynaptic effects of adenosine and adenine nucleotides, in Daly JW, Kuroda Y, Phillis JW, Shimizu PH, Ui M (eds): Physiology and Pharmacology of Adenosine Derivatives. New York, Raven Press, 1983, pp 143–153

    Google Scholar 

  5. Westfall TC: Local regulation of adrenergic neurotransmission. Physiol Rev 57: 659–728, 1977.

    PubMed  CAS  Google Scholar 

  6. Ambache N, Zar MA: Evidence against adrenergic motor transmission in the guinea pig vas deferens. J Physiol (Lond) 216: 359–389, 1971.

    CAS  Google Scholar 

  7. von Euler U, Hedqvist P: Evidence of α- and β2-adrenoceptor-mediated inhibition of the twitch response in the guinea pig vas deferens by noradrenaline. Acta Physiol Scand 93: 572–573, 1975.

    Article  Google Scholar 

  8. Blakeley AGH, Cunnane TC, Petersen SA: An electro pharmacological analysis of the effects of some drugs on neuromuscular transmission in the vas deferens of the guinea pig. J Auton Pharmacol 1: 367–375, 1981.

    Article  PubMed  CAS  Google Scholar 

  9. Luchelli-Fortis MA, Fredholm BB, Langer SZ: Evidence against the presence of presynaptic inhibitory adenosine receptors in the cat nictitating membrane. J Pharmacol Exp Ther 219: 235–242, 1981.

    PubMed  CAS  Google Scholar 

  10. Fredholm BB, Sollevi A: The release of adenosine and inosine from canine subcutaneous adipose tissue by nerve stimulation and noradrenaline. J Physiol 313: 351–367, 1981.

    PubMed  CAS  Google Scholar 

  11. Schwabe U, Ebert R, Erbler HC: Adenosine released from fat cells: Effects on cyclic AMP and hormone actions. Adv Cyclic Nucleotide Res 5: 569–584, 1975.

    PubMed  CAS  Google Scholar 

  12. Sollevi A, Fredholm BB: The antilipolytic effect of endogenous and exogenous adenosine in canine adipose tissue in situ. Acta Physiol Scand 113: 53–60, 1981.

    Article  PubMed  CAS  Google Scholar 

  13. Schrader J: Sites of action and production of adenosine in the heart, in Burnstock G (ed): Purinergic Receptors. London, Chapman and Hall, 1981, pp 121–162.

    Google Scholar 

  14. Hedqvist P, Fredholm BB: Effects of adenosine on adrenergic neurotransmission: Prejunctional inhibition and post junctional enhancement. Naunyn Schmiedebergs Arch Pharmacol 293: 217–223, 1976.

    Article  PubMed  CAS  Google Scholar 

  15. Holck MI, Marks BH: Purine nucleoside and nucleotide interactions on normal and subsensitive alpha adrenoceptor responsiveness in guinea pig vas deferens. J Pharmacol Exp Ther 205: 104–117, 1978.

    PubMed  CAS  Google Scholar 

  16. Sakai KK, Hymsom DL, Shapiro R: The effects of adenosine and adenine nucleotides on the guinea pig vas deferens: Evidence for existence of purinergic receptors. Life Sci 24: 1299–1308, 1979.

    Article  PubMed  CAS  Google Scholar 

  17. Daly JW: Adenosine and cyclic adenosine mono phosphate-generating systems in brain tissue, in Baer HP, Drummond GI (eds): Physiological and Regulatory Functions of Adenosine Nucleotides. New York, Raven Press, 1979, pp 229–241.

    Google Scholar 

  18. Sollevi A, Hjemdahl P, Fredholm BB: Endogenous adenosine inhibits lipolysis induced by nerve stimulation without inhibiting noradrenaline release in canine snbcutaneous adipose tissue in vivo. Naunyn Schmiedebergs Arch Pharmacol 316: 112–119, 1981.

    Article  PubMed  CAS  Google Scholar 

  19. Gustafsson L: Influence of adenosine on responses to vagal nerve stimulation in the anaesthetized rabbit. Acta Physiol Scand 111: 263–268, 1981.

    Article  PubMed  CAS  Google Scholar 

  20. Gustafsson L: Adenosine elicits prejunctional inhibition and post junctional enhancement in rabbit iris sphincter. Acta Physiol Scand 114: 38A, 1982 (abst).

    Google Scholar 

  21. Gustafsson L, Hedqvist P, Fredholm BB, Lundgren G: Inhibition of acetylcholine-release in guinea pig ileum by adenosine. Acta Physiol Scand 104: 469–478, 1978.

    Article  PubMed  CAS  Google Scholar 

  22. Verhaege RH, Vanhoutte PM, Shepherd JT: Inhibition of sympathetic neurotransmission in canine blood vessels by adenosine and adenine nucleotides. Circ Res 40: 208–215, 1977.

    Google Scholar 

  23. Muramatsu I, Fuijiwara M, Miura A, Sakakibara Y: Possible involvement of adenine nucleotides in sympathetic neuroeffector mechanisms of dog basilar artery. J Pharmacol Exp Ther 216: 401–409, 1981.

    PubMed  CAS  Google Scholar 

  24. Wakade AR, Wakade TD: Inhibition of noradrenaline release by adenosine. J Physiol (Lond) 282: 45–49, 1978.

    Google Scholar 

  25. Husted S, Nedergaard OA: Inhibition of adrenergic neuroeffector transmission in rabbit pulmonary artery and aorta by adenosine and adenine nucleotides. Acta Pharmacol Toxicol 49: 334–353, 1981.

    Article  CAS  Google Scholar 

  26. Fredholm BB, Fried G, Hedqvist P: Origin of adenosine released from rat vas deferens by nerve stimulation. Eur J Pharmacol 79: 233–243, 1982.

    Article  PubMed  CAS  Google Scholar 

  27. Clanachan AS, Johns A, Paton DM: Presynaptic inhibitory actions of adenine nucleotides and adenosine on neurotransmission in the rat vas deferens. Neuroscience 2: 597–602, 1977.

    Article  PubMed  CAS  Google Scholar 

  28. Moylan RD, Westfall TC: Effect of adenosine on adrenergic neurotransmission in the super-fused rat portal vein. Blood Vessels 16: 302–310, 1979.

    PubMed  CAS  Google Scholar 

  29. Enero MA, Saidman BQ: Possible feedback inhibition of noradrenaline release by purine compounds. Naunyn Schmiedebergs Arch Pharmacol 297: 39–46, 1977.

    Article  PubMed  CAS  Google Scholar 

  30. Mueller AL, Moisimann WF, Weiner N: Effects of adenosine on neurally mediated norepinephrine release from the cat spleen. Eur J Pharmacol 53: 329–333, 1979.

    Article  PubMed  CAS  Google Scholar 

  31. Hedqvist P, Fredholm BB: Inhibitory effect of adenosine on adrenergic neuroeffector transmission in the rabbit heart. Acta Physiol Scand 105: 120–122, 1979.

    Article  PubMed  CAS  Google Scholar 

  32. Khan MT, Malik KU: Inhibitory effect of adenosine and adenine nucleotides on potassium-evoked efflux of [3H]noradrenaline from the rat isolated heart: Lack of relationship to prostaglandins. Br J Pharmacol 68: 551–561, 1980.

    PubMed  CAS  Google Scholar 

  33. Wakade AR: Studies on secretion of catecholamines evoked by acetylcholine or transmural stimulation of the rat adrenal gland. J Physiol (Lond) 313: 463–480, 1981.

    CAS  Google Scholar 

  34. de Groot WC, Booth AM: Inhibition and facilitation in parasympathetic ganglia of the urinary bladder. Fed Proc 39: 2990–2996, 1980.

    Google Scholar 

  35. Brown DA, Caulfield MP, Kirby PJ: Relation between catecholamine-induced cyclic AMP changes and hyperpolarization in isolated rat sympathetic ganglia. J Physiol (Lond) 290: 441–451, 1979.

    CAS  Google Scholar 

  36. McAfee DA, Henon BK, Whiting GJ, Horn JP, Yarowsky PJ, Turner DK: The action of cAMP and catecholamines in mammalian sympathetic ganglia. Fed Proc 39: 2997–3002, 1980.

    PubMed  CAS  Google Scholar 

  37. Gustafsson L, Fredholm BB, Hedqvist P: Theophylline interferes with the modulatory role of endogenous adenosine on cholinergic neurotransmission. Acta Physiol Scand 111: 269–280, 1981.

    Article  PubMed  CAS  Google Scholar 

  38. Dowdle E, Maske R: The effects of calcium concentration on the inhibition of cholinergic neurotransmission in the myenteric plexus of guinea pig ileum by adenine nucleotides. Br J Pharmacol 71: 245–252, 1980.

    PubMed  CAS  Google Scholar 

  39. Ribeiro JA, Walker J: The effects of adenosine triphosphate and adenosine diphosphate on transmission at the rat and frog neuromuscular junctions. Br J Pharmacol 54: 213–218, 1975.

    PubMed  CAS  Google Scholar 

  40. Silinsky EM: Evidence for specific adenosine receptors at cholinergic nerve endings. Br J Pharmacol 71: 191–194, 1980.

    PubMed  CAS  Google Scholar 

  41. Braănisteanu DD, Anulică ID, Proca B, Nhue BG: Adenosine effects upon transmitter release parameters in the Mg2+ -paralyzed neuromuscular junction of frog. Naunyn Schmiedebergs Arch Pharmacol 308: 273–279, 1979.

    Article  PubMed  Google Scholar 

  42. Israël M, Lesbats B, Manarche R, Meunier FM, Frachon P: Retrograde inhibition of transmitter release by ATP. J Neurochem 34: 923–932, 1980.

    Article  PubMed  Google Scholar 

  43. Vizi ES, Knoll J: The inhibitory effect of adenosine and related nucleotides on the release of acetylcholine. Neuroscience 1: 391–398, 1976.

    Article  PubMed  CAS  Google Scholar 

  44. Wikberg JES, Axelsson KL: A simple and efficient method for studying neurotransmitter release in vitro by a radiotracer technique. Acta Physiol Scand 109: 123–129, 1980.

    Article  PubMed  CAS  Google Scholar 

  45. Hayashi E, Mori M, Yamada S, Kunitomo M: Effects of purine compounds on cholinergic nerves: Specificity of adenosine and related compounds on acetylcholine release in electrically stimulated guinea pig ileum. Eur J Pharmacol 48: 297–307, 1978.

    Article  PubMed  CAS  Google Scholar 

  46. Alberts P, Bartfai T, Stjarne L: Site(s) and ionic basis of α-autoinhibition and facilitation of [3H]noradrenaline secretion in guinea pig vas deferens. J Physiol 312: 297–334, 1981.

    PubMed  CAS  Google Scholar 

  47. Stone TW: Adenosine and related compounds do not affect nerve terminal excitability in the rat CNS. Brain Res 182: 198–200, 1980.

    Article  PubMed  CAS  Google Scholar 

  48. Okada Y, Ozawa S: Inhibitory action of adenosine on synaptic transmission in the hippocampus of the guinea pig in vitro. Eur J Pharmacol 68: 483–492, 1980.

    Article  PubMed  CAS  Google Scholar 

  49. Segal M: Intracellular analysis of a postsynaptic action of adenosine in the rat hippocampus. Eur J Pharmacol 79: 193–199, 1982.

    Article  PubMed  CAS  Google Scholar 

  50. Siggins GR, Schubert P: Adenosine depression of hippocampal neurons in vitro: An intracellular study of dose-dependent actions on synaptic and membrane potentials. Neurosci Lett 23: 55–60, 1981.

    Article  PubMed  CAS  Google Scholar 

  51. Londos C, Wolff J, Cooper DMF: Adenosine as a regulator of adenyl ate cyclase, in Burnstock G (ed): Purinergic Receptors. London, Chapman and Hall, 1981, pp 287–323.

    Google Scholar 

  52. Raberger G: Cardiovascular and metabolic actions of adenosine and adenosine analogs, in Baer HP, Drummond GI (eds): Physiological and Regulatory Functions of Adenosine and Adenine Nucleotides. New York, Raven Press, 1979, pp 155–166.

    Google Scholar 

  53. Dunwiddie TV, Fredholm BB: Adenosine receptors in the rat hippocampus. Br J Pharmacol 77: 347P (abst), 1982.

    Google Scholar 

  54. Zetterström T, Vernet L, Ungerstedt U, Tossman U, Jonzon B, Fredholm BB: Purine levels in the intact rat brain: Studies with an implanted perfused hollow fibre. Neurosei Lett 29: 111–115, 1982.

    Article  Google Scholar 

  55. Hedqvist P, Fredholm BB, Ölund S: Antagonistic effects of theophylline and adenosine on adrenergic neuroeffector transmission in the rabbit kidney. Circ Res 43: 592–598, 1978.

    PubMed  CAS  Google Scholar 

  56. Sollevi A, Östergren J, Hjemdahl P, Fredholm BB, Fagrell B: The effect of dipyridamole on plasma adenosine levels and skin micro-circulation in man. J Clin Chem Clin Bioehem, 1982 (in press).

    Google Scholar 

Download references

Authors
  1. Bertil B. Fredholm
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lars E. Gustafsson
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Per Hedqvist
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alf Sollevi
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Physiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA

    Robert M. Berne  & Rafael Rubio  & 

  2. Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia, USA

    Theodore W. Rall

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Martinus Nijhoff Publishers, The Hague

About this chapter

Cite this chapter

Fredholm, B.B., Gustafsson, L.E., Hedqvist, P., Sollevi, A. (1983). Adenosine in the Regulation of Neurotransmitter Release in the Peripheral Nervous System. In: Berne, R.M., Rall, T.W., Rubio, R. (eds) Regulatory Function of Adenosine. Developments in Pharmacology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3909-0_30

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3909-0_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3911-3

  • Online ISBN: 978-1-4613-3909-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation