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Interactions of Adenosine with other Agents

  • Chapter
Regulatory Function of Adenosine

Part of the book series: Developments in Pharmacology ((DIPH,volume 2))

Abstract

The concept that purines might modify the responses of cells to other agonists can be traced back to the original observations of RaIl and his colleagues [1, 2]. It was found that adenosine not only would elevate the levels of cyclic AMP in slices of guinea pig cerebral cortex but also would potentiate the increase of cyclic AMP produced by norepinephrine [1–3]. A large amount of evidence has since accumulated suggesting that endogenous purines have a variety of effects that may reflect physiological roles [4, 5], and consequently it is necessary to consider that an important function of purines may be to regulate the sensitivity of receptors for other endogenous agents or exogenously administered drugs.

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Authors
  1. Trevor W. Stone
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA

    Robert M. Berne  & Rafael Rubio  & 

  2. Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia, USA

    Theodore W. Rall

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© 1983 Martinus Nijhoff Publishers, The Hague

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Stone, T.W. (1983). Interactions of Adenosine with other Agents. In: Berne, R.M., Rall, T.W., Rubio, R. (eds) Regulatory Function of Adenosine. Developments in Pharmacology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3909-0_29

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  • DOI: https://doi.org/10.1007/978-1-4613-3909-0_29

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3911-3

  • Online ISBN: 978-1-4613-3909-0

  • eBook Packages: Springer Book Archive

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