Abstract
The concept of purinergic modulation of CNS activity by adenine compounds has recently attracted substantial experimental attention. This notion was originally formulated on the basis of observations that certain purine compounds are capable of depressing neuronal activity and are also potent stimulants of cAMP synthesis in the brain [1, 2]. More recently, the identification of multiple adenosine receptors and the availability of radiolabeled ligands with high specific activity has broadened the conceptual and technical approaches within this field. A correlative approach to these different sets of data was one of the primary goals of our current experiments. On the basis of evidence gathered from these technically disparate avenues of approach, a better understanding of purine modulation of CNS function has begun to emerge.
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Schubert, P., Lee, K., Reddington, M., Kreutzberg, G. (1983). Synaptic Modulation by Adenosine: Electrophysiological and Biochemical Characteristics. In: Berne, R.M., Rall, T.W., Rubio, R. (eds) Regulatory Function of Adenosine. Developments in Pharmacology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3909-0_27
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DOI: https://doi.org/10.1007/978-1-4613-3909-0_27
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