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Chronotropic and Dromotropic Effects of Adenosine

  • Chapter
Regulatory Function of Adenosine

Part of the book series: Developments in Pharmacology ((DIPH,volume 2))

Abstract

Since 1929, adenosine has been known to slow sinus rate and cause atrioventricular (A-V) block [1]. Although the coronary vasodilator action of adenosine has received considerable attention in the last two decades, reports on the direct effects of adenosine on the myocardium and specialized conduction system have been relatively few. It is of more than historic interest that the A-V block observed in the guinea pig heart first drew the attention of Drury and Szent-Györgyi to the physiologial activity of the nucleic acid derivatives. They used the induction of A-V block in guinea pigs as a bioassay for the presence of a substance derived from heart muscle extracts, later found to be adenylic acid. Adenosine obtained from yeast nucleic acid was subsequently shown to have a similar action [1].

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Authors
  1. Luiz Belardinelli
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  2. Alexander West
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  3. Richard Crampton
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  4. Robert M. Berne
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Editors and Affiliations

  1. Department of Physiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA

    Robert M. Berne  & Rafael Rubio  & 

  2. Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia, USA

    Theodore W. Rall

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© 1983 Martinus Nijhoff Publishers, The Hague

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Belardinelli, L., West, A., Crampton, R., Berne, R.M. (1983). Chronotropic and Dromotropic Effects of Adenosine. In: Berne, R.M., Rall, T.W., Rubio, R. (eds) Regulatory Function of Adenosine. Developments in Pharmacology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3909-0_24

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  • DOI: https://doi.org/10.1007/978-1-4613-3909-0_24

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