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Adenosine Uptake and Adenine Nucleotide Metabolism by Vascular Endothelium

  • Chapter
Regulatory Function of Adenosine

Part of the book series: Developments in Pharmacology ((DIPH,volume 2))

Abstract

Recent research has emphasized that extracellular purines (particularly adenosine and A TP) may be important regulators of vessel tone, commonly producing vasodilation, through their binding to receptors currently classified as P1 (adenosine) and P2 (ATP) [1]. The direct control of vascular tone has usually been thought of in terms of the action of mediators at receptors on vascular smooth muscle cells, causing contraction or relaxation. However, within the last two years it has been recognized that endothelial cells are necessary modulators of the vasodilator response to several agents, including ATP [2–4]; before the publication of these results, such a role for endothelium in the control of vascular tone had been largely unconsidered. Indeed, until fairly recently, the concept that endothelial cell functions could contribute in any way to the regulation of blood flow, for example, by the metabolism of circulating vasoactive compounds, was not widely recognized.

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Authors
  1. Jeremy D. Pearson
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  2. Paul G. Hellewell
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  3. John L. Gordon
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA

    Robert M. Berne  & Rafael Rubio  & 

  2. Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia, USA

    Theodore W. Rall

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© 1983 Martinus Nijhoff Publishers, The Hague

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Pearson, J.D., Hellewell, P.G., Gordon, J.L. (1983). Adenosine Uptake and Adenine Nucleotide Metabolism by Vascular Endothelium. In: Berne, R.M., Rall, T.W., Rubio, R. (eds) Regulatory Function of Adenosine. Developments in Pharmacology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3909-0_21

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  • DOI: https://doi.org/10.1007/978-1-4613-3909-0_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3911-3

  • Online ISBN: 978-1-4613-3909-0

  • eBook Packages: Springer Book Archive

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