Adenosine Receptors and Adenylate Cyclase Interactions
For many years it has been known that adenosine, at low concentrations, initiates numerous metabolic actions in a variety of cells. Although adenosine effects may result from altered purine metabolism [1, 2], some persist under conditions where the nucleoside is prevented from entering cells. Thus, a number of metabolic effects of adenosine persist or are enhanced in the presence of adenosine transport inhibitors, such as dipyridamole and nitrobenzylthioguanosine. These include inhibition of lipolysis in fat cells , inhibition of platelet aggregation , increased steroid production , potentiation of histamine release from mast cells , inhibition of vas deferens contraction , and coronary vasodilation . Moreover, conjugates of adenosine with large molecules that are thought not to enter cells mimic the actions of free adenosine, the potency of adenosine in the conjugates being similar to that of the free nucleoside [3, 9–12]. Such findings gave birth to the notion that cells contain surface receptors for adenosine.
KeywordsCaffeine Catecholamine Glucagon Neuroblastoma Purine
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