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Inhibition of Nucleoside Transport

  • Chapter
Regulatory Function of Adenosine

Part of the book series: Developments in Pharmacology ((DIPH,volume 2))

Abstract

In many types of animal cells, the movement of nucleoside molecules across the plasma membrane is a specific, transporter-mediated process [1, 2]. The existence of the nucleoside transport mechanism has been recognized from the kinetic properties of nucleoside fluxes, but nucleoside transporter elements of the plasma membrane have not yet been visualized or isolated, and their properties have only been studied indirectly. The potent, tightly bound inhibitor of nucleoside transport, nitrobenzylthioinosine (NBMPR),1 has been a valuable probe of transporter function and biology, enabling, for example, quantitation of transporter elements on cells [3] and providing an approach to their isolation from plasma membrane preparations [4]. This chapter discusses the nucleoside transport-inhibitory properties of NBMPR, N6-nitrobenzyldeoxyadenosine, and certain of their congeners, and of dilazep, a coronary vasodilator.

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Authors
  1. Alan R. P. Paterson
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  2. Ewa S. Jakobs
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  3. Eric R. Harley
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  4. Nai-Wu Fu
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  5. Morris J. Robins
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  6. Carol E. Cass
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Editor information

Editors and Affiliations

  1. Department of Physiology, University of Virginia School of Medicine, Charlottesville, Virginia, USA

    Robert M. Berne  & Rafael Rubio  & 

  2. Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Virginia, USA

    Theodore W. Rall

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© 1983 Martinus Nijhoff Publishers, The Hague

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Paterson, A.R.P., Jakobs, E.S., Harley, E.R., Fu, NW., Robins, M.J., Cass, C.E. (1983). Inhibition of Nucleoside Transport. In: Berne, R.M., Rall, T.W., Rubio, R. (eds) Regulatory Function of Adenosine. Developments in Pharmacology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3909-0_13

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  • DOI: https://doi.org/10.1007/978-1-4613-3909-0_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3911-3

  • Online ISBN: 978-1-4613-3909-0

  • eBook Packages: Springer Book Archive

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