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Herpesviruses

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Abstract

The herpesvirus family (herpes, in Greek, means crawling or creeping, like a snake) named Herpesviridae, consists of viruses that have a similar morphology, but with a host range varying from lower vertebrates (reptiles, fish, and frogs) to humans. These viruses differ from each other antigenically and in the G + C content and organization of the viral DNA.

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Bibliography

  • Adams, A., and Lindahl, T. Epstein-Barr virus genomes with properties of circular DNA molecules in carrier cells. Proc. Natl. Acad. Sci. USA 72:1477–1481 (1975).

    Article  PubMed  CAS  Google Scholar 

  • Aurelian, L., and Strand, B. Herpesvirus type 2 related antigens and their relevance to humoral and cell mediated immunity in patients with cervical cancer. Cancer Res. 36:810–820, 1976.

    PubMed  CAS  Google Scholar 

  • Baringer, J.R. Herpes simplex virus infection of nervous tissue in animals and man. Prog. Med. Virol. 20:1–26, 1975.

    PubMed  CAS  Google Scholar 

  • Becker, Y.; Dym, H.; and Sarov, I. Herpes simplex virus DNA. Virology 36:185–192, 1968.

    Article  Google Scholar 

  • Burkitt, D. A lymphoma syndrome in tropical Africa. Int. Rev. Exp. Pathol. 2:67–138, 1963.

    PubMed  CAS  Google Scholar 

  • Duff, R., and Rapp, F. The induction of oncogenic potential by herpes simplex virus. Perspect. Virol. 8:199–210,1973.

    Google Scholar 

  • Epstein, M.A.; Achong, B.G.; and Barr, Y.M. Virus particles in cultured Iymphoblasts from Burkitt’s lymphoma. Lancet i:702–703, 1964.

    Google Scholar 

  • Falk, L.; Deinhardt, F.; Nonoyama, M.; Wolfe, L.G.; Bergholz, C.; Lapin, B.; Yakovleva, L.; Agrba, V.; Henle, G.; and Henle, W. Properties of a baboon Iymphotropic herpesvirus related to EBV. Int. J. Cancer 18:798–807, 1976.

    Article  PubMed  CAS  Google Scholar 

  • Fleckenstein, B. Oncogenic herpes viruses of non-human primates. Biochim. Biophys. Acta 560:301–342 (1979).

    PubMed  CAS  Google Scholar 

  • Frenkel, N.; Locker, H.; Batterson, W.; Hayward, G.S.; and Roizman, B. Anatomy of herpes simplex virus DNA. VI. Defective DNA originates from the S component. J. Virol. 20:527–531, 1976.

    PubMed  CAS  Google Scholar 

  • Friedmann, A.; Broit, M.; and Becker, Y. Annealing of alkali-resistant HSV DNA strands and isolation of Sand L components. In: Oncogenesis and Herpesviruses III (eds: G. de-The, W. Henle, and F. Rapp), IARC Scientific Publications No. 24, Lyon, 1978, pp. 137–148.

    Google Scholar 

  • Friedmann, A.; Shlomai, J; and Becker, Y. Electron microscopy of herpes simplex virus DNA molecules isolated from infected cells by centrifugation in CsCI density gradients. J. Gen. Virol. 34:507–522, 1977.

    Article  PubMed  CAS  Google Scholar 

  • Garapin, A.C.; Colbere-Garapin, F.; Cohen-Solal, M.; Horodniceanu, F.; and Kourilsky, P. Expression of herpes simplex virus type 1 thymidine kinase gene in Escherichia coli. Proc. Natl. Acad. Sci. USA 78:815–819, 1981.

    Article  CAS  Google Scholar 

  • Gilbert, S., and Dressler, D. DNA replication: the rolling circle model. Cold Spring Harbor Symp. Quant. Bioi. 33:473–484, 1968.

    CAS  Google Scholar 

  • Hampar, B.; Derge, JG.; Martos, L.M.; Tagamets, M.A.; Chang, S.Y.; and Chakrabarty, M. Identification of a critical period during S phase for activation of the Epstein-Barr virus by 5-iododeoxyuridine. Nature New Biol. 244:214–217, 1973.

    CAS  Google Scholar 

  • Henle, G.; Henle, W.; and Diehl, V. Relation of Burkitt’s tumor-associated herpes-type virus to infectious mononucleosis. Proc. Natl. Acad. Sci. USA 59:94–101, 1968.

    Article  PubMed  CAS  Google Scholar 

  • Henle, W., and Henle, G. Effect of arginine deficient media on the herpes-type virus associated with cultured Burkitt tumor cells. J. Virol. 2:182–191, 1968.

    PubMed  CAS  Google Scholar 

  • Henle, W.; Henle, G.; and Horwitz, C.A. Epstein-Barr virus-specific diagnostic tests in infectious mononucleosis. Hum. Pathol. 5:551–565, 1974.

    Article  PubMed  CAS  Google Scholar 

  • Honess, R.W., and Watson, D.H. Unity and diversity in the herpesviruses. J. Gen. Virol. 37:15–37, 1977.

    Article  PubMed  CAS  Google Scholar 

  • Kaufman, H.E. Clinical cure of herpes simplex keratitis by 5-iodo-2′-deoxyuridine. Proc. Soc. Exp. Biol. Med. 109:251–252, 1962.

    PubMed  CAS  Google Scholar 

  • Kaufman, H.E. Ocular antiviral therapy in perspective. J. Infect. Dis. Suppl. 133:A96-A100, 1976.

    Article  PubMed  Google Scholar 

  • Kieff, E.; Given, D.; Powell, A.; King, W.; Dambough, T.; and Raab-Traub, N. Epstein-Barr virus: structure of the viral DNA and analysis of viral RNA in infected cells. Biochim. Biophys. Acta 560:355–373, 1979.

    PubMed  CAS  Google Scholar 

  • Kit, S.; Otsuka, H.; Qavi, H.; and Hazen, M. Herpes simplex virus thymidine kinase activity of thymidine kinase-deficient Escherichia coli K-12 mutant transformed by hybrid plasmids. Proc. Natl. Acad. Sci. USA 78:582–586, 1981.

    Article  PubMed  CAS  Google Scholar 

  • Klein, G. Herpesviruses and oncogenesis. Proc. Natl. Acad. Sci. USA 69:1056–1064, 1972.

    Article  PubMed  CAS  Google Scholar 

  • Klein, G. Studies on the Epstein-Barr virus genome and the EBV-determined nuclear antigen in human malignant disease. Cold Spring Harbor Symp. Quant. Biol. 39:783–790, 1974.

    Google Scholar 

  • McKnight, S.L. The nucleotide sequence and transcript maps of the herpes simplex virus thymidine kinase gene. Nucleic Acids Res. 8:5949–5964, 1980.

    Article  PubMed  CAS  Google Scholar 

  • Melnick, J.L., and Wallis, C. Photodynamic inactivation of herpesvirus. Perspect. Viral. 9:297–314, 1975.

    CAS  Google Scholar 

  • Melnick, J.L., and Wallis, C. Photodynamic inactivation of herpes simplex virus: a status report. Ann. NY Acad. Sci. 284:171–181, 1977.

    Article  PubMed  CAS  Google Scholar 

  • Miller, G.; Shope, T.; Lisco, H.; Still, D.; and Lipman, M. Epstein-Barr virus: transformation, cytopathic changes and viral antigens in squirrel monkey and marmoset leukocytes. Proe. Natl. Acad. Sci. USA 69:383–387, 1972.

    Article  CAS  Google Scholar 

  • Mizell, M.; Joplin, I.; and Isaacs, J.J. Tumor induction in developing frog kidneys by a zonal centrifuge purified fraction of the frog herpes-type virus. Science 165:1134–1137, 1969.

    Article  PubMed  CAS  Google Scholar 

  • Munyon, W.; Kraiselburd, E.; Davis, D.; and Mann, J. Transfer of thymidine kinase to thymidine kinaseless L cells by infection with ultraviolet-irradiated herpes simplex virus. J. Virol. 7:813–820, 1971.

    PubMed  CAS  Google Scholar 

  • Nahmias, A.J.; Naib, Z.M.; and Josey, W.E. Herpesvirus hominis type 2 infection associated with cervical cancer and prenatal disease. Perspect. Virol. 8:73–88, 1971.

    Google Scholar 

  • Nahmias, A.J., and Roizman, B. Infection with herpes simplex viruses 1 and 2. (Review in three parts). N. Engl. J. Med. 289:667, 719, 781, 1973.

    Article  PubMed  CAS  Google Scholar 

  • Nazerian, K. Marek’s disease lymphoma of chickens and its causative herpesvirus. Biochim. Biophys. Acta 560:375–395 (1979).

    PubMed  CAS  Google Scholar 

  • Pagano, J.S., and Shaw, J.E. Molecular probes and genome homology. In: The Epstein-Barr Virus (M.A. Epstein and B.G. Achong, eds.), Springer-Verlag, Berlin, Heidelberg, New York, 1959, pp. 109–146.

    Google Scholar 

  • Pellicer, A.; Wigler, M.; Axel, R.; and Silverstein, S. The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell 14:133–141, 1981.

    Article  Google Scholar 

  • Prusoff, W.H. Studies on the mechanism of action of 5-iododeoxyuridine, an analog of thymidine. Cancer Res. 20:92–95, 1960.

    PubMed  CAS  Google Scholar 

  • Rapp, F., and Reed, C. Experimental evidence for the oncogenic potential of herpes simplex virus. Cancer Res. 36:800–806, 1976.

    PubMed  CAS  Google Scholar 

  • Roizman, B. The structure and isomerization of herpes simplex virus genomes. Cell 16:481–494, 1979.

    Article  PubMed  CAS  Google Scholar 

  • Roizman, B.; Knipe, D.; Morse, L.S.; Ruyechan, W.; and Kovler, M.B. The molecular organization and expression of the herpes simplex virus (HSV) 1 and 2 DNAs. In: Intemational Virology IV. Centre for Agricultural Publishing and Documentation, Wageningen, The Netherlands, 1978, pp. 67.

    Google Scholar 

  • Schaffer, P.A. Temperature-sensitive mutants of herpesviruses. Curro Top. Microbiol. Immunol. 70:51–100,1975.

    CAS  Google Scholar 

  • Sheldrick, P., and Berthelot, N. Inverted repetitions in the chromosome of herpes simplex virus. Cold Spring Harbor Symp. Quam. Biol. 39:667–678, 1974.

    Google Scholar 

  • Southern, E.M. Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98:503–518, 1975.

    Article  PubMed  CAS  Google Scholar 

  • Stevens, J.G. Latent herpes simplex virus and the nervous system. Curro Top. Microbiol. Immrmol. 70:31–50, 1975.

    CAS  Google Scholar 

  • Stow, N.D., and Wilkie, N.M. Physical mapping of temperature-sensitive mutations of herpes simplex virus type 1 by intertypic marker rescue. Virology 90:1–11, 1978.

    Article  PubMed  CAS  Google Scholar 

  • Subak-Sharpe, J.H., and Timbury, M.C. Genetics of herpesviruses. In: Comprehensive Virology (H. Fraenkel-Conrat and R.R. Wagner, eds.), Plenum Press, New York, 1977, Vol. 9, pp. 89–132.

    Google Scholar 

  • de-The, G. Demographic studies implicating the virus in the causation of Burkitt’s lymphoma; prospects for nasopharyngeal carcinoma. In: The epstein-Barr Virus (eds: M.A. Epstein and B.G. Achong), Springer-Verlag, Berlin, Heidelberg, New York, 1979, pp. 417–437.

    Google Scholar 

  • Warren, K.G.; Gilden, D.H.; Brown, S.; Devlin, M.; Wroblewska, Z.; Subak-Sharpe, J.; and Koprowski, H. Isolation of herpes simplex virus from human trigeminal ganglia including ganglia from one patient with multiple sclerosis. Lancet ii:637–639, 1977.

    Article  Google Scholar 

  • Weinberg, A., and Becker, Y. Studies on EB virus of Burkitt lymphoblasts. Virology 39:312–321, 1969.

    Article  PubMed  CAS  Google Scholar 

  • Werner, E.-J.; Bornkamm, G.W.; and Fleckenstein, B. Episomal viral DNA in a herpes-virus saimiri-transformed lymphoid cell line. J. Virol. 22:794–803, 1977.

    PubMed  CAS  Google Scholar 

  • Yamamoto, K.; Mizuno, F.; Matsuo, T.; Tanaka, A.; Nonoyama, M.; and Osaka, T. Epstein-Barr virus and human chromosomes: close association of the resident viral genome and the expression of the virus-determined nuclear antigen (EBN A) with the presence of chromosome 14 in human-mouse hybrid cells. Proc. Natl. Acad. Sci. USA 75:5155–5159, 1978.

    Article  PubMed  CAS  Google Scholar 

  • Yanagi, K.; Talavera, A.; Nishimoto, T.; and Rush, M.G. Inhibition of herpes simplex virus type 1 replication in temperature-sensitive cell cycle mutants. J. Virol. 25:42–50, 1978.

    PubMed  CAS  Google Scholar 

  • Zur Hausen, H. Biochemical detection of the virus genome. In: The Epstein-Barr Virus (eds. M.A. Epstein and B.G. Achong), Springer-Verlag, Berlin, Heidelberg, New York, 1979, pp. 147–153.

    Google Scholar 

Recommended Reading

  • Becker, Y. (ed.) Herpesvirus DNA. Martinus-NijhoffPublishers BV, The Hague, 1981.

    Google Scholar 

  • Epstein, M.A., and Achong, B.G. The Epstein-Barr Virus. Springer-Verlag, Berlin, Heidelberg, New York, 1979.

    Google Scholar 

  • Epstein, M.A., and Achong, B.G. Recent progress in Epstein-Barr virus research. Annu. Rev. Microbiol. 31:421–446,1977.

    Article  PubMed  CAS  Google Scholar 

  • Gallo, RG. (ed.) Recent Advances in Cancer Research, Cell Biology, Molewlar Biology and Tumor Virology. CRC Press Inc., Florida, U.S.A., 1980.

    Google Scholar 

  • Kaplan, A.S. (ed.) The Herpesviruses. Academic Press, New York, 1973.

    Google Scholar 

  • Lonsdale, D.M.; Brown, S.M.; Lang, J.; Subak-Sharpe, J.H.; Koprowski, H.; and Warren, K.G. Variations in herpes simplex virus isolated from human ganglia and a study of clonal variation in HSV-1. Ann. NY Acad. Sci. 354:291–308. 1980.

    Article  PubMed  CAS  Google Scholar 

  • Nahmias, A.J.; Dowdle, W.R; and Schinazi, R.F. (eds.) The Human Herpesviruses. Elsevier, New York, 1981.

    Google Scholar 

  • O’Caliaghan, D.J., and Randall, C.C. Molecular anatomy of herpes viruses: recent studies. Prog. Med. Virol. 22:123–151,1976.

    Google Scholar 

  • Rapp, F. Oncogenic Herpesviruses. CRC Press Inc., Florida, U.S.A., 1980.

    Google Scholar 

  • Rawls, W.E.; Bacchetti, S.; and Graham, F.L. Relation of herpes simplex viruses to human malignancies. Curro Top. Microbiol. Immunol. 77:71–95, 1977.

    CAS  Google Scholar 

  • Roizman, B., and Furlong, D. The replication of herpesviruses. In: Comprehensive Virology (H. Fraenkel-Conrat and R.R Wagner, eds.) Plenum Press, New York, 1977, Vol. 9, pp. 89–132.

    Google Scholar 

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Julia Hadar

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© 1983 Martinus Nijhoff Publishers, The Hague

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Becker, Y., Hadar, J. (1983). Herpesviruses. In: Hadar, J. (eds) Molecular Virology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3906-9_7

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  • DOI: https://doi.org/10.1007/978-1-4613-3906-9_7

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