Skip to main content

Comparison of Renal Hemodynamics in Black and White Patients with Essential Hypertension

  • Chapter
Book cover Kidney in Essential Hypertension

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 35))

Abstract

Systemic, splanchnic, and renal hemodynamic data, determined in 60 male and female, black and white, untreated and uncomplicated essential hypertensive patients, confirmed our previous systemic hemodynamic findings. When black and white patients were matched for age, sex, and mean arterial pressure, cardiac index and total peripheral resistance were similar at all levels of pressure. This suggests that hypertensive vascular disease is no more severe in blacks. This conclusion could be confirmed further by our splanchnic hemodynamic findings. However, in contrast to these findings, renal blood flow was less and renal vascular resistance was higher at any mean arterial pressure (or total peripheral resistance) level in blacks—especially in men. These findings tend to support those reports suggesting that hypertensive disease—in particular, renal morbidity—is more severe in the black.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Comstock BW: An epidemiologic study of blood pressure levels in a biracial community in the southern United States. American Journal of Hygiene (65):271–315, 1957.

    PubMed  CAS  Google Scholar 

  2. U.S. Department of Health, Education and Welfare: Blood pressure of adults by race and area, United States, 1960–1962. National Health Survey, National Center for Health Statistics Series 11, No. 5, 1964.

    Google Scholar 

  3. Stamler J, Rhomberg P, Schoenberger JA, Shekelle RB, Dyer A, Shekell S, Stamler R, Wannemaker J: Multivariate analysis of the relationship of seven variables to blood pressure. J Chronic Dis (28):527–548, 1975.

    Article  PubMed  CAS  Google Scholar 

  4. Cruickshank JK, Beevers DG: Epidemiology of hypertension: Blood pressure in blacks and whites. Clin Sci (62):1–6, 1982.

    PubMed  CAS  Google Scholar 

  5. McDonough JR, Garrison GE, Hames CG: Blood pressure and hypertensive disease among negroes and whites. Ann Intern Med (61):208–228, 1964.

    PubMed  CAS  Google Scholar 

  6. Freis ED: Age, race, sex and other indices of risk in hypertension. Am J Med (55):275–280, 1973.

    Article  Google Scholar 

  7. Entwisle G, Apostolides AY, Hebel JR, Henderson MM: Target organ damage in black hypertensives. Circulation (55):792–796, 1977.

    PubMed  CAS  Google Scholar 

  8. The HDFP Cooperative Group: Sex and race differences in end organ damage among 10,940 hypertensives. Am J Cardiol (41):402 (abstract), 1978.

    Google Scholar 

  9. Gillum RF: Pathophysiology of hypertension in blacks and whites. A review of the basis of racial blood pressure differences. Hypertension (l):468–475, 1979.

    PubMed  CAS  Google Scholar 

  10. Levy SB, Talner LB, Coel MN, Holle R, Stone RA; Renal vasculature in essential hypertension: Racial differences. Ann Intern Med (88):12–16, 1978.

    PubMed  CAS  Google Scholar 

  11. Rostand SG, Kirk KA, Rutsky EA, Pat BA: Racial differences in the incidence of treatment for end-stage renal disease. N Engl J Med (306):1276–1278, 1982.

    Google Scholar 

  12. Messerli FH, De Carvalho JFG, Christie B, Frohlich ED: Essential hypertension in black and white subjects. Hemodynamic findings and fluid volume state. Am J Med (67):27–31, 1979.

    Google Scholar 

  13. Voors AW, Berenson GS, Dalferes ER, Shuler SE: Racial differences in blood pressure control. Science (204):1091–1094, 1979.

    Google Scholar 

  14. Lilley JJ, Hsu L, Stone RA: Racial disparity of plasma volume in hypertensive man. Ann Intern Med (84):707–711, 1976.

    Google Scholar 

  15. Chrysant SG, Danisa K, Kem D, Dillard BL, Smith WJ, Frohlich ED: Racial differences in pressure, volume and renin interrelationships in essential hypertension. Hypertension (1):136–141, 1979.

    Google Scholar 

  16. Creditor MC, Loschky UK: Plasma renin activity in hypertension. Am J Med (43):371–382, 1967.

    Google Scholar 

  17. Brunner HR, Sealey JE, Laragh JH: Renin as a risk factor in essential hypertension. More evidence. Am J Med (55):295–302, 1973.

    Google Scholar 

  18. Kilcoyne MM, Thomson GE, Branche G, Williams M, Garner C, Chiles B, Soland T: Characteristics of hypertension in the black population. Circulation (50):1006–1013, 1974.

    Google Scholar 

  19. Sever PS, Peart WS, Meade TW, Davies IB, Gordon D: Ethnic differences in blood pressure with observations on noradrenaline and renin. 1. A working population. Clin Exper Hypertens (l):733–744, 1979.

    Google Scholar 

  20. Sever PS, Peart WS, Davies IB, Turnbridge RDG, Gordon D: Ethnic differences in blood pressure with observations on noradrenaline and renin. 2. A hospital hypertensive population. Clin Exper Hypertens (l):745–760, 1979.

    Google Scholar 

  21. Messerli FH, De Carvalho JGR, Christie B, Frohlich ED: Systemic and regional hemodynamics in low, normal and high cardiac output borderline hypertension. Circulation (58):441–448, 1978.

    Google Scholar 

  22. Winer BJ: Statistical Principles in Experimental Design. McGraw-Hill Publishing Co, New York, 1971.

    Google Scholar 

  23. Dustan HP, Tarazi RC, Frohlich ED: Functional correlates of plasma renin activity in hypertensive patients. Circulation (41):555–567, 1970.

    Google Scholar 

  24. Vaughan ED Jr, Laragh JH, Gavras I, Buhler F, Gavras H, Brunner HR, Baer L: Volume factor in low and normal renin essential hypertension: Treatment with either spironolactone or chlorthalidone. Am J Cardiol (32):523–532, 1973.

    Google Scholar 

  25. Buhler FR, Laragh JH, Baer L, Vaughan ED Jr, Brunner HR: Propranolol inhibition of renin secretion. A specific approach to diagnosis and treatment of renin-dependent hypertensive diseases. N Engl J Med (287):1209–1214, 1972.

    Article  PubMed  CAS  Google Scholar 

  26. Woods JW, Pittman AW, Pulliam CC, Werk EE, Waider W, Allen CA: Renin profiling in hypertension and its use in treatment with proporanolol and chlorthalidone. N Engl J Med (294):1137–1143, 1976.

    Article  PubMed  CAS  Google Scholar 

  27. Holland OB, Gomez-Sanchez C, Fairchild C, Kaplan NM: Role of renin classificiation for diuretic treatment of black hypertensive patients. Arch Intern Med (139):1365 – 1370, 1979.

    Article  PubMed  CAS  Google Scholar 

  28. Humphreys DG, Delvin DG: Ineffectiveness of propranolol in hypertensive Jamaicans. Br Med J (2):601–603, 1968.

    Article  PubMed  CAS  Google Scholar 

  29. Veterans Administration Cooperative Study Group on Antihypertensive Agents. Comparison of propranolol and hydrochlorothiazide for the initial treatment of hypertension. I. Results of short-term titration with emphasis on racial differences in response. And II. Results of long-term therapy. JAMA (248):1996–2003 and 2004–2011, 1982.

    Google Scholar 

  30. Frohlich ED, Messerli FH: Sodium. In: Papper S (ed), Vol 2, Cations of biologic significance. CRC Press, Boca Raton, Florida, 1982.

    Google Scholar 

  31. Woods KL, Beevers DG, West M: Familiar abnormality of erythrocyte cation transport in essential hypertension. Br Med J (282):1186–1188, 1981.

    Article  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Martinus Nijhoff Publishing, Boston/The Hague/Dordrecht/Lancaster

About this chapter

Cite this chapter

Frohlich, E.D., Messerli, F.H., Dunn, F.G. (1984). Comparison of Renal Hemodynamics in Black and White Patients with Essential Hypertension. In: Messerli, F.H. (eds) Kidney in Essential Hypertension. Developments in Cardiovascular Medicine, vol 35. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3897-0_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3897-0_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3899-4

  • Online ISBN: 978-1-4613-3897-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics