Summary
Recent reports have emphasised two aspects of measles persistence. Firstly, an apparent lack of immune response towards the matrix protein is associated with an apparent defect in the production of this polypeptide, and secondly antibody can act at the cell membrane to affect the synthesis of intracellular polypeptides and might thus account for the observed lack of matrix protein. We have investigated possible reasons underlying inability to produce M protein and now report that this may be accomplished at the level of mRNA turnover and function. In addition we have examined the mechanism of antibody-in-duced antigenic modulation and report that this process apparently involves alterations in the synthesis of virus-specific RNAs. These findings may be of significance in the analysis of all cell lines in which antibody has been used to produce cell curing.
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© 1984 Martinus Nijhoff Publishing, Boston
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Carter, M.J., Barrett, P.N., Willcocks, M.M., Koschel, K., ter Meulen, V. (1984). Factors Involved in Measles Virus Persistence. In: Kohn, A., Fuchs, P. (eds) Mechanisms of Viral Pathogenesis. Developments in Molecular Virology, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3894-9_7
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DOI: https://doi.org/10.1007/978-1-4613-3894-9_7
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