Summary
Three rat cell lines (RE, ES and RT21) chronically infected with Moloney Murine Leukemia Virus (M0-MuLV) became sensitive to infection with EMC virus and to the antiviral effect of mouse interferon. These two properties are specific to mouse cells only. EMC virus multiplies in M0-MuLV infected rat cells to a titer of 108 pfu and destroys the infected cells. Mouse interferon induces an antiviral state in these cells when challenged with EMC or VSV viruses, and causes inhibition of 97 per cent of M0-MuLV release. These properties are observed only in rat cells chronically infected with M0-LV obtained from mouse, but not in those infected with Moloney Leukemia Virus obtained from rat (M0-RLV).
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© 1984 Martinus Nijhoff Publishing, Boston
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Oren, R., Teitz, Y. (1984). Transplantation of Mouse Genes into Rat Cells Chronically Infected by Moloney Murine Leukemia Virus (M0-MuLV). In: Kohn, A., Fuchs, P. (eds) Mechanisms of Viral Pathogenesis. Developments in Molecular Virology, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3894-9_10
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DOI: https://doi.org/10.1007/978-1-4613-3894-9_10
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