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The Use of Young Nude Mice to Study Metastasis of Human Neoplasms

  • Chapter
Adrenal and Endocrine Tumors in Children

Part of the book series: Cancer Treatment and Research ((CTAR,volume 17))

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Abstract

Understanding the pathobiological processes of cancer metastasis is fundamental to the development of successful cancer therapies. The process of metastasis involves a series of sequential events in which malignant cells are released from the primary tumor and reach distant sites where they proliferate to form new tumor foci. Metastasis begins with the local invasion of the surrounding host tissue by cells from the primary tumor. Tumors that grow in the major body cavities can shed cells which seed the mucosal and/or serosal surfaces of other organs and develop into secondary growths. The more common route of tumor spread involves invasion and penetration of tumor cells into blood vessels and/or the lymphatic system [1–4]. Release of tumor emboli is accelerated by intermittent changes in venous pressure, by turbulent blood flow, and by movement or manipulation of the neoplasms during routine examination, biopsy or surgery [1–5].

Research sponsored by the National Cancer Institute, DHHS, under Contract No. N01-CO-75380 with Litton Bionetics, Inc. The contents of this publications do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.

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Authors
  1. Nabil Hanna
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  2. Vincent A. Pollack
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  3. Isaiah J. Fidler
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Editor information

Editors and Affiliations

  1. Department of Pediatrics, Hematology-Oncology Oklahoma Children’s Memorial Hospital, University of Oklahoma Health Sciences Center, P.O. Box 26307, Oklahoma City, OK, 73126, USA

    G. Bennett Humphrey M.D., Ph.D.

  2. Department M-305, Lilly Research Laboratories, 307 E. McCarty Street, Indianapolis, IN, 46285, USA

    Gerald B. Grindey

  3. Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Box 609, Mayo Memorial Building, Minneapolis, MN, 55455, USA

    Louis P. Dehner

  4. Diabetes Research Hospital, University of Alabama in Birmingham, Room 817 1808 7th Avenue, South Brimingham, AL, 35233, USA

    Ronald T. Acton Ph.D.

  5. Department of Pathology Oklahoma Children’s Memorial Hospital, University of Oklahoma Health Sciences Center, P.O. Box 26307, Oklahoma City, OK, 73126, USA

    Theodore J. Pysher

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© 1983 Martinus Nijhoff Publishers, Boston

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Hanna, N., Pollack, V.A., Fidler, I.J. (1983). The Use of Young Nude Mice to Study Metastasis of Human Neoplasms. In: Humphrey, G.B., Grindey, G.B., Dehner, L.P., Acton, R.T., Pysher, T.J. (eds) Adrenal and Endocrine Tumors in Children. Cancer Treatment and Research, vol 17. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3891-8_1

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  • DOI: https://doi.org/10.1007/978-1-4613-3891-8_1

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