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Upon the enigma of Hodgkin’s disease and the Reed-Sternberg cell

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Controversies in the Management of Lymphomas

Part of the book series: Cancer Treatment and Research ((CTAR,volume 16))

Abstract

If our hundred year quest for the cell of origin of Hodgkin’s disease has taught us anything, it is the importance of maintaining an open mind, preferably with a cheerful capacity for changing it according to the dictates of fashion. Every cell has had its day; as prospective candidates all cells are equal, but (as we shall see) some are more equal than others.

‘This enlargement of the glands appears to be a primitive affection of those bodies, rather than the result of an irritation propagated to them from some ulcerated surface or other inflamed texture.’ (Thomas Hodgkin 1832)

Following this description of ‘Some Morbid Appearance of the Absorbent Glands and Spleen’ [1], the problems of the nature, nomenclature, diagnosis and clinical definition of tumors of the lymphoid system have promoted fierce controversy among clinicians and pathilogists, falling just short of bloodshed. The accumulated literature is now beyond the compass of any one individual, and conflicts abound; the problem is not so much a shortage of data, as a lackof consensus concerning its validity or import.

All animals are equal, but some are more equal than others.

Proclamation of the Pig, Napoleon,

George Orwell, Animal Farm, 1946

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  1. Clive R. Taylor
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Editors and Affiliations

  1. Medical Oncology Division, Cancer Center of the University of Rochester Medical Center, Rochester, New York, USA

    John M. Bennett M.D. (Head) (Head)

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© 1983 Martinus Nijhoff Publishers, Boston.

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Taylor, C.R. (1983). Upon the enigma of Hodgkin’s disease and the Reed-Sternberg cell. In: Bennett, J.M. (eds) Controversies in the Management of Lymphomas. Cancer Treatment and Research, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3885-7_4

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  • DOI: https://doi.org/10.1007/978-1-4613-3885-7_4

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