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Pitfalls in the diagnosis and classification of Hodgkin’s disease: Surgical pathology and classification for the 1980’s

Is the Lukes-Butler classification still relevant?

  • Chapter
Controversies in the Management of Lymphomas

Part of the book series: Cancer Treatment and Research ((CTAR,volume 16))

Abstract

Compared to the controversies surrounding the pathologic classification of the non-Hodgkin’s lymphomas, the pathologic classification of Hodgkin’s disease (HD) has produced barely a murmur of discontent. Perhaps the dramatically improved prognosis in patients with HD [1–3] has occasioned little need for criticism. HD is classified according to the Rye modification [4] of the histologic classification proposed by Lukes and Butler [5] (Table 1). Early series of patients classified according to this scheme showed significant and reproducible variations in survival among the different histologic subtypes [6]. However, current data show that pathologic stage is the most important prognostic factor and histologic classification per se does not have significant influence on prognosis when other parameters are held constant [7–13]. These findings have led some to question the usefulness of classification in HD.

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Authors
  1. Thomas V. Colby
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Editors and Affiliations

  1. Medical Oncology Division, Cancer Center of the University of Rochester Medical Center, Rochester, New York, USA

    John M. Bennett M.D. (Head) (Head)

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© 1983 Martinus Nijhoff Publishers, Boston.

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Colby, T.V. (1983). Pitfalls in the diagnosis and classification of Hodgkin’s disease: Surgical pathology and classification for the 1980’s. In: Bennett, J.M. (eds) Controversies in the Management of Lymphomas. Cancer Treatment and Research, vol 16. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3885-7_2

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  • DOI: https://doi.org/10.1007/978-1-4613-3885-7_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3887-1

  • Online ISBN: 978-1-4613-3885-7

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