Role of Radiotherapy

  • Robert D. Lindberg
Part of the Cancer Treatment and Research book series (CTAR, volume 15)

Abstract

The role of radiation therapy in the treatment of adult soft tissue sarcomas has undergone a transition during the past two decades. Until recently, radical surgical excision has been considered the only curative treatment since soft tissue sarcomas were known to be ‘radioresistant.’ This concept of radioresistance was based on early published reports. In 1928, Rostock [1] reported on a collected series of 505 patients with soft tissue sarcoma. Although 78% of the sarcomas responded favorable immediately following irradiation, only 2.9% of the patients were cured as compared to a 30%, 5-year cure rate in another group of 550 patients treated by surgery alone. Thus, the concept of ‘radioresistance’ was firmly established and surgery became the treatment of choice.

Keywords

Toxicity Oncol Sarcoma Assure Melphalan 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    RostockP: Indikationsstellung and dauerertoigder rontgenbestrahlung bei sarkomen. Fortschr d Therap 4: 241, 1928.Google Scholar
  2. 2.
    Leucutia T: Radiotherapy of sarcoma of the soft parts. Radiology 25: 403, 1935.Google Scholar
  3. 3.
    Leucutia T: Treatment of disease of the skeletal system, joints, and soft tissues. In: Clinical Therapeutic Radiology. New York: Thomas Nelson and Sons, 1950.Google Scholar
  4. 4.
    Cade S: Soft tissue tumors: Their natural history and treatment. Proc R Soc Med 44: 19, 1951.PubMedGoogle Scholar
  5. 5.
    Fortner JG: Soft tissue sarcomas. Clin Bull 5: 62, 1975.Google Scholar
  6. 6.
    McNeer GP, Cantin J, Chu F, Nickson JJ: Effectiveness of radiotherapy in the management of sarcoma of soft tissues. Cancer 22: 391–397, 1968.PubMedCrossRefGoogle Scholar
  7. 7.
    Lindberg RD: The role of radiation therapy in the treatment of soft tissue sarcoma in adults. In: Proceedings of Seventh National Cancer Conference. Philadelphia: JB Lippincott Co, 1973, p 883.Google Scholar
  8. 8.
    Reitan JB, Kaalhus O: Radiotherapy of liposarcomas. Br J Radiol 53: 969–975, 1980.PubMedCrossRefGoogle Scholar
  9. 9.
    Salinas R, Hussey DH, Fletcher GH, Lindberg RD, Martin RG, Peters LJ, Sinkovics JG: Experience with fast neutron therapy for locally advanced sarcomas. Int J Radiat Oncol Biol Phys 6: 267–272, 1980.PubMedCrossRefGoogle Scholar
  10. 10.
    del Regato JA: Radiotherapy of soft tissue sarcomas. JAMA 185: 216–218, 1963.Google Scholar
  11. 11.
    Russell WO, Cohn J, Enzinger F, Hajdu SI, Heise H, Martin RG, Meissner W, Miller WT, Schmitz RL, Suit HD: A clinical and pathological staging system for soft tissue sarcomas. Cancer 40: 1562–1570, 1977.PubMedCrossRefGoogle Scholar
  12. 12.
    Simon MA, Enneking WF: The management of soft tissue sarcomas of the extremities. J Bone Joint Surg 58A (3): 317–327, 1976.PubMedGoogle Scholar
  13. 13.
    Simon MA, Spanier SS, Enneking WF: Management of adult soft tissue sarcomas of the extremities. Ann Surg 11: 363–402, 1979.Google Scholar
  14. 14.
    Fletcher GH: Elective irradiation of subclinical disease in cancers of the head and neck. Cancer 29: 1450–1454, 1972.PubMedCrossRefGoogle Scholar
  15. 15.
    Fletcher GH: Local results of irradiation in the primary management of localized breast cancer. Cancer 29: 545–551, 1972.PubMedCrossRefGoogle Scholar
  16. 16.
    Lindberg RD, Martin RG, Romsdahl MM, Barkley HT: Conservation surgery and postoperative radiotherapy in 300 adults with soft tissue sarcomas. Cancer 47: 2391–2397, 1981.PubMedCrossRefGoogle Scholar
  17. 17.
    Coe MA, Madden FJ, Mould RF: The role of radiotherapy in the treatment of soft tissue sarcomas: A retrospective study 1958–73. Clin Radiol 32: 42–51, 1981.CrossRefGoogle Scholar
  18. 18.
    Lindberg RD, Fletcher GH, Martin RG: The management of soft tissue sarcomas in adults: Surgery and postoperative radiotherapy. J Radiol Electrol 56: 761–767, 1975.Google Scholar
  19. 19.
    Lindberg RD: Soft tissue sarcoma. In: Textbook of Radiotherapy, Fletcher GH (ed). Philadelphia: Lea & Febiger, 1980 (3rd ed.), pp 922–942.Google Scholar
  20. 20.
    Rosenberg SA, Kent H, Costa J, Webber BL, Young R, Chabner B, Baker AR, Brennan MF, Chretien PB, Cohen MH, deMoss EV, Sears HF, Scipp C, Simon R: Prospective randomized evaluation of the role of limb-sparing surgery, radiation therapy, and adjuvant chemoimmunotherapy in the treatment of adult soft tissue sarcomas. Surgery 84: 62–69, 1978.PubMedGoogle Scholar
  21. 21.
    Atkinson L, Garvan JM, Newton NC: Behavior and management of soft connective tissue sarcomas. Cancer 16: 1552–1562, 1963.PubMedCrossRefGoogle Scholar
  22. 22.
    Martin RG, Lindberg RD, Russell WO: Preoperative radiotherapy and surgery in the management of soft tissue sarcoma. In: Management of Primary Bone and Soft Tissue Tumors. Chicago: Year Book Medical Publishers, 1977, pp 299–307.Google Scholar
  23. 23.
    Suit HD, Proppe KH, Monkin HJ, Wood WC: Preoperative radiation therapy for sarcoma of soft tissue. Cancer 47: 2269–2274, 1981.PubMedCrossRefGoogle Scholar
  24. 24.
    Lindberg RD: Unpublished data 1972.Google Scholar
  25. 25.
    Lindberg RD, Murphy WK, Benjamin RS, Sinkovics JG, Martin RG, Romsdahl MM, Jesse RH, Russell WO: Adjuvant chemotherapy in the treatment of primary soft tissue sarcomas: A preliminary report. In: Management of Primary Bone and Soft Tissue Tumors. Chicago: Year Book Medical Publishers, 1977, pp 343–352.Google Scholar
  26. 26.
    Stehlin JS, de Ipolyi PD, Giovanella BC, Gutierrez AE, Anderson RF: Soft tissue sarcomas of the extremity. Multidisciplinary therapy employing hyperthermia perfusion. Am J Surg 130: 643–646, 1975.PubMedCrossRefGoogle Scholar
  27. 27.
    Eiber FR, Mirra J J, Grant TT, Wersenburger T, Morton DL: Is amputation necessary for sarcomas? A seven–year experience with limb salvage. Ann Surg 192: 431–438, 1980.CrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, Boston/The Hague/Dordrecht/Lancaster 1983

Authors and Affiliations

  • Robert D. Lindberg

There are no affiliations available

Personalised recommendations