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Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase

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Enzyme Induction and Modulation

Part of the book series: Developments in molecular and cellular biochemistry ((DMCB,volume 3))

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Summary

Within the last few years considerable evidence has accumulated which indicates that changes in HMG- CoA reductase are due primarily, if not solely, to changes in enzyme quantity. These include the changes caused by insulin, glucagon, cholesterol, mevalonolactone, cholestyramine, compactin, cyclic monoterpenes and the diurnal rhythm. Investigations of whether these changes in enzyme quantity primarily represent changes in rates of enzyme synthesis or degradation are just beginning. Regulation of reductase activity by reversible phosphorylation seems unlikely when all the available data are critically examined.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, College of Medicine, University of South Florida, Tampa, FL, 33612, USA

    Gene C. Ness

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  1. Gene C. Ness
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Editors and Affiliations

  1. Division of Protein Chemistry, Tufts University School of Medicine, Boston, Massachusetts, USA

    V. A. Najjar

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© 1983 Martinus Nijhoff Publishers, Boston

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Ness, G.C. (1983). Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase. In: Najjar, V.A. (eds) Enzyme Induction and Modulation. Developments in molecular and cellular biochemistry, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3879-6_19

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  • DOI: https://doi.org/10.1007/978-1-4613-3879-6_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3881-9

  • Online ISBN: 978-1-4613-3879-6

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