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Role and induction of 2,3-bisphosphoglycerate synthase

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Enzyme Induction and Modulation

Part of the book series: Developments in molecular and cellular biochemistry ((DMCB,volume 3))

Summary

2,3-Bisphosphoglycerate accumulates in mammalian erythrocytes, where it facilitates the supply of oxygen to the tissues by binding to hemoglobin. Regulatory properties of 2,3-bisphosphoglycerate synthase and phosphatase are discussed.

The 2,3-bisphosphoglycerate concentration was shown to rise linearly along with the hemoglobin level during erythroid differentiation. The accumulation of 2,3-bisphosphoglycerate was primarily attributable to an increase in 2,3-bisphosphoglycerate synthase. Antibody-binding studies showed that the increased activity is achieved solely through an increase in the amount of enzyme. It was shown that 2,3-bisphosphoglycerate synthase was synthesized in nucleated erythroid precursor cells and also in anucleated reticulocytes. The mRNA of this protein appears to be fairly stable in reticulocytes. Coordinate expression of hemoglobin and 2,3-bisphosphoglycerate synthase was found during dimethylsulfoxide-induced differentiation of Friend erythroleukemia cells. 2,3-Bisphosphoglycerate rose concomitantly.

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Author information

Authors and Affiliations

  1. Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Kyoto, 606, Japan

    Ryuzo Sasaki & Hideo Chiba

Authors
  1. Ryuzo Sasaki
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  2. Hideo Chiba
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Editor information

Editors and Affiliations

  1. Division of Protein Chemistry, Tufts University School of Medicine, Boston, Massachusetts, USA

    V. A. Najjar

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© 1983 Martinus Nijhoff Publishers, Boston

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Sasaki, R., Chiba, H. (1983). Role and induction of 2,3-bisphosphoglycerate synthase. In: Najjar, V.A. (eds) Enzyme Induction and Modulation. Developments in molecular and cellular biochemistry, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3879-6_15

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  • DOI: https://doi.org/10.1007/978-1-4613-3879-6_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3881-9

  • Online ISBN: 978-1-4613-3879-6

  • eBook Packages: Springer Book Archive

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