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Regulation of β-chain mRNA of ovine follicle-stimulating hormone by 17β-estradiol

  • Chapter
Enzyme Induction and Modulation

Part of the book series: Developments in molecular and cellular biochemistry ((DMCB,volume 3))

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Summary

17 β-Estradiol (E2) rapidly and reversibly decreases the synthesis of follicle-stimulating hormone (FSH) in primary dispersed cell cultures of ovine pituitaries. Similarly, E2 also causes a decrease in the messenger RN A for the beta subunit of ovine FSH (FSHβ-mRNA) as measured in an in vitro translation assay. These results are consistent with the concept that E2 directly regulates either transcription of the FSHβ gene or processing of FSHβ-mRNA in sheep. Of additional interest is the observation that pituitary cultures from various species respond differently to E2 in terms of FSH synthesis. For example, E2 stimulates FSH synthesis in rat pituitary cultures, has no effect in similar rabbit cultures, and inhibits FSH synthesis in ovine cultures. Thus, a set of eukaryotic ‘mutants’ may exist to aid studies of the effect of E2 on FSH synthesis and secretion.

Contribution from the Department of Biochemistry, School of Agriculture and School of Physical and Mathematical Sciences. Paper No. 8529 of the Journal Series, North Carolina 27650-5050.

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References

  1. Notides, A. C., 1970. Endocrinology 87: 987–992.

    Article  PubMed  CAS  Google Scholar 

  2. Wise, P. M. and Payne, A. H., 1975. Mol. Cell Endocrinol. 3: 385–395.

    Article  PubMed  CAS  Google Scholar 

  3. Tang, L. K. L. and Spies, H. G., 1975. Endocrinology 96: 349–356.

    Article  PubMed  CAS  Google Scholar 

  4. Labrie, F., Drouin, J., De Lean, A., Lagace, L., Ferland, L. and Beaulieu, M., 1977. Adv. Exp. Med. Biol. 87: 157–179.

    PubMed  CAS  Google Scholar 

  5. Drouin, J., Lavoie, M. and Labrie, F., 1978. Endocrinology 102: 358–361.

    Article  PubMed  CAS  Google Scholar 

  6. Steinberger, A. and Chowdhury, M., 1974. Endocr. Res. Commun. 1: 389–401.

    Article  PubMed  Google Scholar 

  7. Miller, W. L. and Wu, J., 1981. Endocrinology 108: 673–679.

    Article  PubMed  CAS  Google Scholar 

  8. Ryan, R., Shupnik, M. A. and Gorski, J., 1979. Biochemistry 18: 2044–2048.

    Article  PubMed  CAS  Google Scholar 

  9. McKnight, G. S. and Palmiter, R. D., 1979. J. Biol. Chem. 254: 9050–5058.

    PubMed  CAS  Google Scholar 

  10. McKnight, G. S., Lee, D. C. and Palmiter, R. D., 1980. J. Biol. Chem. 255: 148–153.

    PubMed  CAS  Google Scholar 

  11. Hayward, M. A., Mitchell, T. A. and Shapiro, D. J., 1980. J. Biol. Chem. 255: 11308–11312.

    PubMed  CAS  Google Scholar 

  12. Kaplan, S. L., Grumbach, M. M. and Aubert, M. L., 1976. J. Clin. Endocrinol. Metab. 42: 995–998.

    Article  PubMed  CAS  Google Scholar 

  13. Landefeld, T. D., 1979. J. Biol. Chem. 254: 3685–3688.

    PubMed  CAS  Google Scholar 

  14. Landefeld, T. D. and Kepa, J., 1979. Biochem. Biophys. Res. Commun. 90: 1111–1118.

    Article  PubMed  CAS  Google Scholar 

  15. Godine, J. E., Chin, W. W. and Habener, J. F., 1981. J. Biol. Chem. 256: 2475–2479.

    Google Scholar 

  16. Chin, W. W., Habener, J. F., Kieffer, J. D. and Maloof, F., 1978. J. Biol. Chem. 253: 7985–7988.

    PubMed  CAS  Google Scholar 

  17. Giudice, L. C. and Weintraub, B. D., 1979. J. Biol. Chem. 254: 12679–12683.

    Google Scholar 

  18. Huang, E. S. and Miller, W. L., 1980. Biol. Reprod. 23: 124–134.

    Article  PubMed  CAS  Google Scholar 

  19. Miller, W. L., Knight, M. M., Grimek, H. J. and Gorski, J., 1977. Endocrinology 100: 1306–1316.

    Article  PubMed  CAS  Google Scholar 

  20. Sherwood, O. D., Grimek, H. J. and McShan, W. H., 1970. J. Biol. Chem. 245: 2328–2336.

    Google Scholar 

  21. Sairam, M. R., 1979. Arch. Biochem. Biophys. 194: 71–78.

    Article  PubMed  CAS  Google Scholar 

  22. Alexander, D. C. and Miller, W. L., 1982. J. Biol. Chem. 257: 2282–2286.

    Google Scholar 

  23. Alexander, D. C. and Miller, W. L., 1981. J. Biol. Chem. 256: 12628–12631.

    PubMed  CAS  Google Scholar 

  24. Grimek, H. J. and McShan, W. H., 1974. J. Biol. Chem. 249: 5725–5732.

    Google Scholar 

  25. Vician, L., Shupnik, M. A. and Gorski, J., 1979. Endocri¬nology 104: 736–743.

    Article  CAS  Google Scholar 

  26. Miller, W. L., Knight, M. M. and Gorski, J., 1977. Endocri¬nology 101: 1455–1460.

    Article  CAS  Google Scholar 

  27. Miller, W. L. and Huang, E. S., 1981. Endocrinology 108: 96102.

    Google Scholar 

  28. Scott, W. A. and Tomkins, G. M., 1975. In: Methods in Enzymology. (O’Malley, B. W. and Hardman, J. G., Eds.), Vol. XL, Part E, p. 278, New York: Academic Press.

    Google Scholar 

  29. Karsch, F. J., Foster, D. L., Legan, S. J., Ryan, K. D. and Peter, G. K., 1979. Endocrinology 105: 421–426.

    Article  PubMed  CAS  Google Scholar 

  30. Katzenellenbogen, B. S. and Gorski, J., 1975. In: Estrogen Actions on Synthesis of Macromolecules in Target Cells. (Litwack, G., ed.), p. 187, New York: Academic Press.

    Google Scholar 

  31. Pierce, J. G. and Parsons, T. F., 1981. Ann. Rev. Biochem. 50: 465–495.

    Article  PubMed  CAS  Google Scholar 

  32. Godine, J. E., Chin, W. W. and Habener, J. F., 1980. J. Biol. Chem. 255: 8780–8783.

    PubMed  CAS  Google Scholar 

  33. Sairam, M. R., Seiday, N. G. and Chretien, M., 1981. Bio¬chem. J. 197: 541–552.

    CAS  Google Scholar 

  34. Schanbacher, B. D. and Ford, J. J., 1977. Endocrinology 100: 387–393.

    Article  PubMed  CAS  Google Scholar 

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Author information

Author notes

  1. D. C. Alexander

    Present address: Plant Cell Research Institute, 6560 Trinity Court, Dublin, CA, 94566, USA

  2. E. S. Huang

    Present address: Environmental Protection Agency, Health Effects Research Laboratory, Developmental Biology Division, Reproductive Toxicology Branch, Research Triangle Park, NC, 27711, USA

Authors and Affiliations

  1. Department of Biochemistry, North Carolina State University, Raleigh, NC, 27650-5050, USA

    W. L. Miller, D. C. Alexander, J. C. Wu, E. S. Huang, G. K. Whitfield & S. H. Hall

Authors
  1. W. L. Miller
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  2. D. C. Alexander
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  3. J. C. Wu
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  4. E. S. Huang
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  5. G. K. Whitfield
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  6. S. H. Hall
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Editor information

Editors and Affiliations

  1. Division of Protein Chemistry, Tufts University School of Medicine, Boston, Massachusetts, USA

    V. A. Najjar

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© 1983 Martinus Nijhoff Publishers, Boston

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Miller, W.L., Alexander, D.C., Wu, J.C., Huang, E.S., Whitfield, G.K., Hall, S.H. (1983). Regulation of β-chain mRNA of ovine follicle-stimulating hormone by 17β-estradiol. In: Najjar, V.A. (eds) Enzyme Induction and Modulation. Developments in molecular and cellular biochemistry, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3879-6_11

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  • DOI: https://doi.org/10.1007/978-1-4613-3879-6_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3881-9

  • Online ISBN: 978-1-4613-3879-6

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