Do Animal Models Predict Results in Man?

  • E. Neil Moore
  • Joseph F. Spear
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 25)


No single experimental animal model is adequate to define the probability of antiarrhythmic efficacy in man. However, by utilizing a series of animal models for the evaluation of new antiarrhythmic agents it is possible to predict with assurance that a compound will have antiarrhythmic activity. The problem in finding useful new cardiac drugs is not in identifying agents with good activity but rather in finding antiarrhythmic activity without undesirable side effects.


Ventricular Fibrillation Antiarrhythmic Drug Antiarrhythmic Agent Ventricular Tachyarrhythmia Purkinje Fiber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Martinus Nijhoff Publishers, Boston 1983

Authors and Affiliations

  • E. Neil Moore
  • Joseph F. Spear

There are no affiliations available

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