Skip to main content
SpringerLink
Log in

Therapy of Established Tumors by Adoptive Transfer of T Lymphocytes

  • Chapter
Basic and Clinical Tumor Immunology

Part of the book series: Cancer Treatment and Research ((CTAR,volume 14))

Abstract

The demonstrations that tumor cells express surface antigens which can serve as targets for immunologic attack have long enticed laboratory and clinical investigators into attempts at manipulating the immune system to promote in vivo tumor destruction. Modulation of the immune system of a tumor-bearing host has been attempted by a variety of experimental approaches, from highly nonspecific by administering chemical immunoadjuvants which enhance general immunologic reactivity to highly specific by infusing purified monoclonal antibodies or cloned T cells which recognize and react to only a single antigenic determinant on tumor cells. Unfortunately, although tumor cells can be readily killed in vitro by many distinct immunologic effector mechanisms, attempts to amplify and utilize the same effector mechanisms in vivo for the therapy of established tumors has been difficult in animal models and generally unsuccessful in human tumor therapy. The difficulties encountered in treating established tumors have served to highlight the need for developing and studying animal models in which the individual parameters for successful immunotherapy can be isolated and examined, the immunologic mechanisms potentially operative in vivo for lysis of established tumor can be elucidated and amplified, and the factors which limit the efficacy of immunotherapy can be identified and eliminated. In this chapter, studies in animal models from our and other laboratories pertaining to one method of modulating the immune system of the host to facilitate tumor destruction will be reviewed — adoptive cellular immunotherapy with immune T cells.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Reference

  1. McKenzie IFC, Potter T: Murine lymphocyte surface antigens. Adv Immunol 27: 179, 1979

    PubMed  CAS  Google Scholar 

  2. Reinherz EL, Schlossman SF: The differentiation and function of human T lymphocytes. Cell 19: 821, 1980

    PubMed  CAS  Google Scholar 

  3. Gillis S, Smith KA: Long-term culture of tumor-specific cytotoxic T cells. Nature 268: 154, 1977

    PubMed  CAS  Google Scholar 

  4. Zarling JM, Bach FH: Continuous culture of T cells cytotoxic for autologous human leukemia cells. Nature 280: 685, 1979

    PubMed  CAS  Google Scholar 

  5. Gillis S, Baker PE, Ruscetti FW, Smith KA: Long-term culture of human antigen-specific cytotoxic T cell lines. J Exp Med 148: 1093, 1978

    PubMed  CAS  Google Scholar 

  6. Perry LL, Benacerraf B, McCluskey RT, Greene MI: Enhanced syngeneic tumor destruction by in vivo inhibition of suppressor T cells using anti-IJ alloantiserum. Am J Path 92: 491, 1978

    PubMed  CAS  Google Scholar 

  7. Earley DD, Hugenberger L, McVay-Boudreau L, Shen FW, Gershon RK, Cantor H: Immunoregulatory circuits among T-cell sets: I. T-helper cells induce other T-cell sets to exert feedback inhibition. J Exp Med 147: 1106, 1978

    Google Scholar 

  8. Cantor H, McVay-Boudreau L, Hugenberger J, Naidorf K, Shen FW, Gershon RK: Immunoregulatory circuits among T-cell sets: II. Physiologic role of feedback inhibition in vivo: Absence in NZB mice. J Exp Med 147: 1116, 1978

    PubMed  CAS  Google Scholar 

  9. Cantor HJ, Hugenberger J, McVay-Boudreau L, Eardley DD, Kemp J, Shen FW, Gershon RK: Immunoregulatory circuits among T-cell sets: Identification of a subpopulation of T-helper cells that induces feedback inhibition. J Exp Med 148: 871, 1978

    PubMed  CAS  Google Scholar 

  10. Lee SK, Oliver RTD: Autologous leukemia-specific T-cell-mediated lymphocytotoxicity in patients with acute myelogenous leukemia. J Exp Med 147: 912, 1978

    PubMed  CAS  Google Scholar 

  11. McGee JOD, Woods J, Ashall F, Bramwell ME, Harris H: A new marker for human cancer cells: 2. Immunohistochemical detection of the Ca antigen in human tissues with the CA1 antibody. Lancet 2: 7, 1982

    PubMed  CAS  Google Scholar 

  12. Badger CC, Bernstein ID: Therapy of murine leukemia with monoclonal antibody against a normal differentiation antigen. J Exp Med, in press

    Google Scholar 

  13. Weiden PL, Flournoy N, Thomas ED, Prentice R, Fefer A, Buckner CD, Storb R: Antileukemic effect of graft-versus-host disease in human recipients of allogeneic-marrow grafts. New Engl J Med 300: 1068, 1979

    PubMed  CAS  Google Scholar 

  14. Weiden PL, Sullivan KM, Flournoy N, Storb R, Thomas ED, the Seattle Marrow Transplant Team: Antileukemic effect of chronic graft-versus-host disease: Contribution to improved survival after allogeneic marrow transplantation. N Engl J Med 304: 1529, 1981

    PubMed  CAS  Google Scholar 

  15. Rosenberg SA, Terry WD: Passive immunotherapy of cancer in animals and man. Adv Cancer Res 25: 323; 347; 366, 1977

    Google Scholar 

  16. Berendt MJ, North RJ: T-cell-mediated suppression of antitumor immunity: An explanation for progressive growth of an immunogenic tumor. J Exp Med 151: 59, 1980

    Google Scholar 

  17. Fujimoto S, Greene MI, Sehon AH: Regulation of the immune response to tumor antigens: I. Immunosuppressor cells in tumor-bearing hosts. J Immunol 116: 800, 1976

    PubMed  CAS  Google Scholar 

  18. Hellstrom KE, Hellstrom I: Lymphocyte-mediated cytotoxicity and blocking serum activity to tumor antigens. Adv Immunol 18: 209, 1974

    PubMed  CAS  Google Scholar 

  19. Borberg H, Oettgen HF, Choudry K, Beathie EJ: Inhibition of established transplants of chemically induced sarcomas in syngeneic mice by lymphocytes from immunized donors. Internatl J Cancer 10: 539, 1972

    CAS  Google Scholar 

  20. Smith HG, Harmel RP, Hanna MG, Zwilling BS, Zbar BS, Rapp HJ: Regression of established intradermal tumors and lymph node metastases in guinea pigs after systemic transfer of immune lympoid cells. J Natl Cancer Inst 58: 1315, 1977

    PubMed  CAS  Google Scholar 

  21. Fefer A, Einstein AB, Cheever MA, Berenson JR: Models for syngeneic adoptive chemoimmunotherapy of murine leukemias. Ann NY Acad Sci 276: 573, 1976

    PubMed  CAS  Google Scholar 

  22. Berendt MJ, North RJ, Kirstein DP: The immunological basis of endotoxic-induced tumor regression: Requirement for T cell mediated immunity. J Exp Med 148: 1550, 1978

    PubMed  CAS  Google Scholar 

  23. Dye ES, North RJ: T cell mediated immunosuppression as an obstacle to adoptive immunotherapy of the P815 mastocytoma and its metastases. J Exp Med 154: 1033, 1981

    PubMed  CAS  Google Scholar 

  24. Fefer A: Immunotherapy of primary Moloney sarcoma virus-induced tumors. Internatl J Cancer 5: 327, 1970

    CAS  Google Scholar 

  25. Colavo D, Zanovello P, Leuchars E, Davies AJS, Chieco-Bianchi L, Biasi G: Moloney murine sarcoma virus oncogenesis in T-lymphocyte-deprived mice: Biologic and immunologic studies. J Natl Cancer Inst 64: 97, 1980

    Google Scholar 

  26. Fernandez-Cruz E, Woda BA, Feldman JD: Elimination of syngeneic sarcomas in rats by a subset of T lymphocytes. J Exp Med 152: 823, 1980

    PubMed  CAS  Google Scholar 

  27. North RJ: Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells. J Exp Med 55: 1063, 1982

    Google Scholar 

  28. Spitalny GL, North RJ: Subversion of host defense mechanisms by malignant tumors: An established tumor as a privileged site for bacterial growth. J Exp Med 145: 1264, 1977

    PubMed  CAS  Google Scholar 

  29. Treves AJ, Cohen IR, Feldman M: Immunotherapy of lethal metastases by lymphocytes sensitized against tumor cells in vitro. J. Natl Cancer Inst 54: 777, 1975

    PubMed  CAS  Google Scholar 

  30. Barnes DWH, Loutit JR, Neal FE: Treatment of murine leukemia with x-rays and homologous bone marrow. Br Med J 2: 626, 1959

    Google Scholar 

  31. DeVries MJ, Vos P: Treatment of mouse lymphosarcoma by total body x-irradiation and by injection of bone marrow and lymph node cells. J. Natl Cancer Inst 21: 1117, 1958

    Google Scholar 

  32. Fefer A: Adoptive chemoimmunotheraphy of a Moloney lymphoma. Internatl J Cancer 8: 364, 1971

    CAS  Google Scholar 

  33. Mihich E: Combined effects of chemotherapy and immunity against leukemia L1210 in DBA/2 mice. Cancer Res 29: 848, 1969

    PubMed  CAS  Google Scholar 

  34. Vadlamudi S, Padarathsingh M, Bonmasser E, Goldin A: Effect of combination treatment with cyclophosphamide and syngeneic or allogeneic spleen and bone marrow cells in leukemic (LI210) mice. Internatl J Cancer 7: 160, 1971

    CAS  Google Scholar 

  35. Fass L, Fefer A: Factors related to therapeutic efficacy in adoptive chemoimmunotherapy of a Friend virus-induced lymphoma. Cancer Res 32:2427, 1972,

    Google Scholar 

  36. Kedar E, Raanan Z, Schwartzbach M: In vitro induction of cell-mediated immunity to murine leukemia cells: VI. Adoptive immunotherapy in combination with chemotherapy of leukemia in mice, using lymphocytes sensitized in vitro to leukemia cells. Cancer Immunol Immunother 4: 161, 1978

    Google Scholar 

  37. Cheever MA, Greenberg PD, Fefer A: Specificity of adoptive chemoimmunotherapy of established syngeneic tumors. J Immunol 125: 711, 1980

    PubMed  CAS  Google Scholar 

  38. Einstein AB, Cheever MA, Fefer A: The use of dimethylmyleran in adoptive chemoimmunotherapy of two murine leukemias. J Natl Cancer Inst 56: 609, 1976

    PubMed  Google Scholar 

  39. Klein DL, Brown W, Cote P, Garner W, Pearson JW: Chemoadoptive immunotherapy against a guinea-pig leukemia. Cancer Immunol Immunother 6: 17, 1979

    Google Scholar 

  40. Greenberg PD, Cheever MA, Fefer A: Detection of early and delayed anti-tumor effects following curative adoptive chemoimmunotherapy of established leukemias. Cancer Res 40: 4428, 1980

    PubMed  CAS  Google Scholar 

  41. McCoy JL, Fefer A, Glynn JP: Comparative studies on the induction of transplantation resistance in BALB/c and C57BL/6 mice in three murine leukemia systems. Cancer Res 27: 1743, 1967

    PubMed  CAS  Google Scholar 

  42. Fernandez-Cruz E, Halliburton B, Feldman JD: In vivo elimination by specific effector cells of an established syngeneic rat Moloney virus-induced sarcoma. J Immunol 123: 1772, 1979

    PubMed  CAS  Google Scholar 

  43. Fernandez-Cruz E, Gilman SC, Feldman JD: Immunotherapy of a chemically-induced sarcoma in rats: Characterization of the effector T cell subset and nature of suppression. J Immunol 128: 1112, 1982

    PubMed  CAS  Google Scholar 

  44. Zinkernagel RM, Doherty PC: MCH-restricted cytotoxic T cells: Studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness. Adv Immunol 27: 51, 1979

    PubMed  CAS  Google Scholar 

  45. Plata F, Jongeneel V, Cerottini J-C, Brunner KT: Antigenic specificity of the cytolytic T lymphocyte (CTL) response to murine sarcoma virus-induced tumors: I. Preferential reactivity of in vitro generated secondary CTL with syngeneic tumor cells. Eur J Immunol 6: 823, 1976

    PubMed  CAS  Google Scholar 

  46. Gomard E, Duprez V, Henin Y, Levy JP: H-2 region product as determinant in immune cytolysis of syngeneic tumor cells by anti-MSV lymphocytes. Nature 260: 707, 1976

    PubMed  CAS  Google Scholar 

  47. Holden HT, Herberman RB: Cytotoxicity against tumour-associated antigens not H-2 restricted. Nature 268: 250, 1977

    PubMed  CAS  Google Scholar 

  48. Stutman O, Shen F-W: H-2 restriction and non-restriction of T-cell-mediated cytotoxicity against mouse mammary tumour targets. Nature 276: 181, 1978

    PubMed  CAS  Google Scholar 

  49. Gomard E, Levy JP, Plata F, Henin Y, Duprez V, Bismuth A, Reme T: Studies on the nature of the cell surface antigen reacting with cytolytic T lymphocytes in murine oncornavirus-induced tumors. Eur J Immunol 8: 228, 1978

    PubMed  CAS  Google Scholar 

  50. Greenberg PD, Cheever MA, Fefer A: H-2 restriction of adoptive immunotherapy of advanced tumors. J Immunol 126: 2100, 1981

    PubMed  CAS  Google Scholar 

  51. Berenson JR, Einstein AB, Fefer A: Syngeneic adoptive immunotherapy and chemoimmunotherapy of a Friend leukemia: Requirement for T cells. J Immunol 115: 234, 1975

    PubMed  CAS  Google Scholar 

  52. Cheever MA, Greenberg PD, Fefer A: Therapy of leukemia by non-immune syngeneic spleen cells. J Immunol 124: 2137, 1980

    PubMed  CAS  Google Scholar 

  53. Cheever MA, Greenberg PD, Fefer A: Chemoimmunotherapy of a Friend leukemia with cells secondarily sensitized in vitro: Effect of culture duration on therapeutic efficacy. J Natl Cancer Inst 67: 169, 1981

    PubMed  CAS  Google Scholar 

  54. Greenberg PD, Cheever MA, Fefer A: Prerequisites for successful adoptive immunotherapy: Nature of effector cells and role of H-2 restriction. In: The potential role of T cells in cancer therapy, Fefer A, Goldstein AL (eds). New York: Raven Press, 1982, pp 31 - 51

    Google Scholar 

  55. Cantor H, Boyse E: Regulation of the immune response by T-cell subclasses. Contemp Top Immunobiol 7: 47, 1977

    PubMed  CAS  Google Scholar 

  56. Shiku H, Takahashi T, Bean MA, Old LJ, Oettgen HF: Ly phenotype of cytotoxic T cells for syngeneic tumor. J Exp Med 144: 1116, 1976

    PubMed  CAS  Google Scholar 

  57. Green WR, Nowinski RC, Henney CS: The generation and specificity of cytotoxic T cells raised against syngeneic tumor cells bearing AKR/Gross murine leukemia virus antigens. J Exp Med 150: 51, 1979

    PubMed  CAS  Google Scholar 

  58. Nakayama E, Shiku H, Stockert E, Oettgen HF, Old LJ: Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera. Proc Natl Acad Sci USA 76: 1977, 1979

    PubMed  CAS  Google Scholar 

  59. Leclerc J. C, Cantor H: T cell-mediated immunity to oncornavirus-induced tumors: I. Ly phenotype of precursor and effector cytolytic T lymphocytes. J Immunol 124: 846, 1980

    PubMed  CAS  Google Scholar 

  60. Stutman O, Shen F. W, Boyse EA: Ly phenotype of T cells cytotoxic for syngeneic mouse mammary tumors: Evidence for T cell interactions. Proc Natl Acad Sci USA 74: 5667, 1977

    PubMed  CAS  Google Scholar 

  61. Greenberg PD, Cheveer MA, Fefer A: Eradication of disseminated Murine Leukemia by chemoimmunotherapy with cyclophosphamide and adoptively transferred immune syngeneic Lyt-l + 2~ lymphocytes. J Exp Med 154: 952, 1981

    PubMed  CAS  Google Scholar 

  62. Chapdelaine JM, Plata F, Lilly F: Tumors induced by murine sarcoma virus contain precursor cells capable of generating tumor-specific cytolytic T lymphocytes. J Exp Med 149: 1531, 1979

    PubMed  CAS  Google Scholar 

  63. MacDonald HR, Cerottini J. C, Ryser, J. E, Maryanski JL, Taswell C, Widmer MB, Brunner KT: Quantitation and cloning of cytolytic T lymphocytes and their precursors. Immunol Rev 51: 93, 1980

    PubMed  CAS  Google Scholar 

  64. Perry LL, Dorf ME, Bach BA, Benacerraf B, Greene MI: Mechanisms of regulation of cell-mediated immunity: Anti-I-A alloantisera interfere with induction and expression of T-cell-mediated immunity to cell-bound antigen in vivo. Clin Immunol Immunopathol 15: 279, 1980

    PubMed  CAS  Google Scholar 

  65. Loveland BE, Hogarth PM, Ceredig R, McKenzie IFC: Cells mediating graft rejection in the mouse: I. Lyt-1 cells mediate skin graft rejection. J Exp Med 153: 1044, 1981

    PubMed  CAS  Google Scholar 

  66. Fujiwara H, Hamaoka T, Shearer GM, Yamamoto H, Terry WD: The augmentation of in vitro and in vivo tumor-specific T cell-mediated immunity by amplifier T lymphocytes. J Immunol 124: 863, 1980

    PubMed  CAS  Google Scholar 

  67. Leclerc J. C, Cantor H: T cell-mediated immunity to oncornavirus-induced tumors: II. Ability of different T cell sets to prevent tumor growth in vivo. J Immunol 124: 851, 1980

    PubMed  CAS  Google Scholar 

  68. Huber B, Cantor H, Shen F. W, Boyse EA: Independent differentiative pathways of Lyl and Ly23 subclasses of T ceils: Experimental production of mice deprived of selected T-cell subclasses. J Exp Med 144: 1128, 1976

    PubMed  CAS  Google Scholar 

  69. Noar D: Suppressor cells: Permitters and promotors of malignancy? Adv in Cancer Res 29: 45, 1979

    Google Scholar 

  70. Plescia OJ, Smith AH, Grinwich K: Subversion of immune system by tumor cells and role of prostaglandins. Proc Natl Acad Sci USA 72: 1848, 1975

    PubMed  CAS  Google Scholar 

  71. Mokyr MB, Braun DB, Dray S: Augmentation of the antitumor cytotoxicity in MOPC-315 tumor bearer spleen cells by depletion of glass-adherent cells prior to in vitro activation. Cancer Res 39: 785, 1979

    PubMed  CAS  Google Scholar 

  72. Greenberg PD, Cheever MA, Fefer A: Suppression of the in vitro secondary response to syngeneic tumor and of in vivo tumor therapy with immune cells by culture-induced suppressor cells. J. Immunol 123: 515, 1979

    PubMed  CAS  Google Scholar 

  73. Turk JL, Parker D, Poulter LW: Functional aspects of the selective depletion of lymphoid tissue by cyclophosphamide. Immunology 23: 493, 1972

    PubMed  CAS  Google Scholar 

  74. Fass L, Fefer A: The application of an in vitro cytotoxicity test to studies of the effects of drugs on the cellular immune response in mice: I. Primary response. J Immunol 109: 749, 1972

    PubMed  CAS  Google Scholar 

  75. Glaser M: Regulation of specific cell-mediated cytotoxic response against SV40-induced tumor-associated antigens by depletion of suppressor T cells with cyclophosphamide in mice. J Exp Med 149: 774, 1979

    PubMed  CAS  Google Scholar 

  76. Greenberg PD, Cheever MA, Fefer A: Role of host and donor cells in tumor elimination following adoptive chemoimmunotherapy (ACIT). Proc Am Assoc Cancer Res 23: 1014, 1982 (abstract)

    Google Scholar 

  77. Zaleski M, Klein J: Genetic control of the immune response to Thy-1 antigens. Immunol Rev 38: 120, 1978

    PubMed  CAS  Google Scholar 

  78. Hayry P, Anderson LC: Generation of T memory cells in one-way mixed lymphocyte culture: IV. Primary and secondary responses to soluble and insoluble membrane preparations and to ultraviolet light inactivated stimulator cells. Scand J Immunol 5: 391, 1976

    PubMed  CAS  Google Scholar 

  79. Hellstrom I, Hellstrom KE: Specific sensitization of lymphocytes to tumor antigens by co-cultivation with peritoneal cells exposed to such antigens. Int. J Cancer 17: 748, 1976

    PubMed  CAS  Google Scholar 

  80. Treves AJ, Schechter B, Cohen IR, Feldman M: Sensitization of T lymphocytes in vitro by syngeneic macrophages fed with tumor antigens. J Immunol 116: 1059, 1976

    PubMed  CAS  Google Scholar 

  81. Kail MA, Hellstrom I: Specific stimulatory and cytotoxic effects of lymphocytes sensitized in vitro to either alloantigens or tumor antigens. J. Immunol 114: 1083, 1975

    Google Scholar 

  82. Plata F, Cerottini JC, Brunner KT: Primary and secondary in vitro generation of cytolytic T lymphocytes in the murine sarcoma virus system. Eur J Immunol 5: 227, 1975

    PubMed  CAS  Google Scholar 

  83. Ting CC, Bonard GD: Cell-mediated immunity to Friend virus-induced leukemia: IV. In vitro generation of primary and secondary cell-mediated cytotoxic responses. J Immunol 116:1419, 1976

    Google Scholar 

  84. Burton RB, Chism SE, Warner NL: In vitro induction and expression of T-cell immunity to tumor associated antigens. Contemp Top Immunobiol 8: 69, 1978

    PubMed  CAS  Google Scholar 

  85. Rollinghoff M, Wagner H: Brief communication: In vitro protection against murine plasma cell tumor growth by in vitro activated syngeneic lymphocytes. J Natl Cancer Inst 51: 1317, 1973

    PubMed  CAS  Google Scholar 

  86. Small M, Trainin N: Separation of populations of sensitized lymphoid cells into fractions inhibiting and fractions enhancing syngeneic tumor growth in vivo. J Immunol 117: 292, 1976

    PubMed  CAS  Google Scholar 

  87. Cheever MA, Greenberg PD, Fefer A: Adoptive therapy of established syngeneic leukemia by cells primarily sensitized in vitro. Cancer Res 41: 2658, 1981

    PubMed  CAS  Google Scholar 

  88. Burton RC, Warner NL: In vitro induction of tumor-specific immunity: IV. Specific adoptive immunotherapy with cytotoxic T cells induced in vitro to plasmacytoma antigens. Cancer Immunol Immunother 2: 91, 1977

    Google Scholar 

  89. Plata F, Jongeneel CV: Characterization of effector lymphocytes associated with immunity to murine sarcoma virus (MSV)-induced tumors: II. Repeated stimulation and proliferation in vitro of specific cytolytic T lymphocytes. J Immunol 119: 623, 1977

    PubMed  CAS  Google Scholar 

  90. Bernstein I: Passive transfer of a systemic tumor immunity with cells generated in vitro by a secondary immune response to a syngeneic rat Gross-virus-induced lymphoma. J Immunol 118: 122, 1977

    PubMed  CAS  Google Scholar 

  91. Mills GB, Carlson G, Paetkau V: Generation of Cytotoxic lymphocytes to syngeneic tumors by using co-stimulator (Interleukin 2): In vivo activity. J Immunol 125: 1904, 1980

    PubMed  CAS  Google Scholar 

  92. Cheever MA, Greenberg PD, Fefer A: Tumor neutralization, immunotherapy, and che-moimmunotherapy of a Friend leukemia with cells secondarily sensitized in vitro: II. Comparison of cells cultured with and without tumor to noncultured immune cells. J Immunol 121: 2220, 1978

    PubMed  CAS  Google Scholar 

  93. Wagner H, Rollinghoff M: T-T cell interaction during in vitro cytotoxic allograft responses: I. Soluble products from activated Ly 1+ T cells trigger autonomously antigen-primed Ly 23+ T cells to cell proliferation and cytolytic activity. J Exp Med 148: 1523, 1978

    PubMed  CAS  Google Scholar 

  94. Shaw J, Caplan B, Paetkau V, Pilarski LM, Delovitch TL, McKenzie IFC: Cellular origins of co-stimulator (IL 2) and its activity in cytotoxic T lymphocyte responses. J Immunol 124: 2231, 1980

    PubMed  CAS  Google Scholar 

  95. Bonnard GD, Yasaka K, Jacobson D: Ligand-activated T cell growth factor-induced proliferation: Absorption of T cell growth factor by activated T cells. J Immunol 123: 2704, 1979

    PubMed  CAS  Google Scholar 

  96. Smith KA, Gillis S, Baker PE, McKenzie D, Ruscetti FW: T cell growth factor mediated T cell proliferation. Ann NY Acad Sci 332: 423, 1979

    PubMed  CAS  Google Scholar 

  97. Gillis S, Mochizuki DY, Conlon PJ, Hefeneider SH, Ramthun CA, Gillis AE, Frank MB, Henney CS, Watson JD: Molecular characterization of Interleukin 2. Immunol Rev 63: 167, 1982

    PubMed  CAS  Google Scholar 

  98. Watson J: Continuous proliferation of murine antigen-specific helper T lymphocytes in culture. J Exp Med 150: 1510, 1979

    PubMed  CAS  Google Scholar 

  99. Schreier MH, Tees R: Clonal induction of helper T cells: Conversion of specific signals into nonspecific signals. Int Archs Allergy Appl Immun 61: 227, 1980

    CAS  Google Scholar 

  100. Smith KA, Gillis S, Baker P: The inhibition of in vivo tumor growth by cytotoxic T cell lines. Proc of Am Assoc Ca Res 20:93, 1979. Abstract

    Google Scholar 

  101. Cheever MA, Greenberg PD, Fefer A: Specific adoptive therapy of established leukemia with syngeneic lymphocytes sequentially immunized in vivo and in vitro and non-specifically expanded by culture with Interleukin 2. J Immunol 126: 1318, 1981

    PubMed  CAS  Google Scholar 

  102. Cheever MA, Greenberg PD, Gillis S, Fefer A: Specific adoptive therapy of murine leukemia with cells secondarily sensitized in vitro and expanded by culture with Interleukin 2. In: The potential role of T cells in cancer therapy, Fefer A, Goldstein AL (eds). New York: Raven Press, 1982, p 127

    Google Scholar 

  103. Lotze MT, Line BR, Mathisen DJ, Rosenberg SA: The in vivo distribution of autologous human and murine lymphoid cells grown in T cell growth factor (TCGF): Implications for the adoptive immunotherapy of tumors. J Immunol 125: 1487, 1980

    PubMed  CAS  Google Scholar 

  104. Dailey MO, Fathman CG, Butcher EC, Pillemer E, Weismann I: Abnormal migration of T lymphocyte clones. J Immunol 128: 2134, 1982

    PubMed  CAS  Google Scholar 

  105. Cheever MA, Greenberg PD, Fefer A, Gillis S: Augmentation of the anti-tumor therapeutic efficacy of Long-term cultured T lymphocytes by in vivo administration of purified Interleukin 2. J Exp Med 155: 968, 1982

    PubMed  CAS  Google Scholar 

  106. Wescott O, Dorsch S, Roser B: Adoptive immunotherapy of leukemia in the rat, without graft-vs-host complications. J Immunol 123: 1478, 1979

    Google Scholar 

  107. Boranic M, Tonkovic I: Time pattern of the antileukemic effect of the graft-versus-host reaction in mice. Cancer Res 31: 1140, 1970

    Google Scholar 

  108. Kende M, Keys LD, Gaston M, Goldin A: Immunochemotherapy of transplantable Moloney leukemia with cyclophosphamide and allogeneic spleen lymphocytes and reversal of graft-versus-host disease with alloantiserum. Cancer Res 35: 346, 1975

    PubMed  CAS  Google Scholar 

  109. Putnam DL, Kind PD, Goldin A, Kende M: Adoptive immunochemotherapy of a transplantable AKR leukemia (K36). Internatl J Cancer 21: 230, 1978

    Google Scholar 

  110. Truitt RL, Bortin MM: Adoptive immunotherapy of malignant disease: Model systems and their relevance to human disease. In: Organ transplantation: Present status, future goals, Slavin S (ed). Amsterdam: Elsevier/North Holland. In press

    Google Scholar 

  111. Yamada Y, Kawamura T, Gotohda E, Akiyama J, Hosokawa M, Kodama T, Kobayashi H: Effect of normal allogeneic lymphoid cell transfer in combination with chemotherapy on a transplantable tumor in rats. Cancer Res 40: 954, 1980

    PubMed  CAS  Google Scholar 

  112. Bortin MM, Truitt RL: Graft-versus-leukaemia reactivity induced by ailoimmunisation without augmentation of graft-versus-host reactivity. Nature 281: 490, 1979

    PubMed  CAS  Google Scholar 

  113. Bortin MM, Rimm AA, Saltzstein EC, Rodey GE: Graft versus leukemia: III. Apparent independent antihost and antileukemic activity of transplanted immunocompetent cells. Transplantation 16: 182, 1973

    PubMed  CAS  Google Scholar 

  114. Korngold R, Sprent J: Features of T cells causing H-2-restricted lethal graft-vs-host disease across minor histocompatibility barriers. J Exp Med 155: 872, 1982

    PubMed  CAS  Google Scholar 

  115. Bevan MJ: Cytotoxic T-cell response to histocompatibility antigens: The role of H-2. Cold Spring Harbor Symp Quant Biol 41: 519, 1976

    Google Scholar 

  116. MacPhail S, Yron I, Stutman O: Primary in vitro cytotoxic T cell response to non-major histocompatibility complex alloantigens in normal mice. J Exp Med 156:610, 1982. MacPhail S, Stutman O: Suppressor T cells activated in a primary in vitro response to non-major histocompatibility alloantigens. J Exp Med 156: 1398, 1982

    CAS  Google Scholar 

Download references

Authors
  1. Philip D. Greenberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Martin A. Cheever
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Alexander Fefer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. National Cancer Institute, Frederick Cancer Research Facility, Frederick, Maryland, USA

    Ronald B. Herberman

Rights and permissions

Reprints and permissions

Copyright information

© 1983 Martinus Nijhoff Publishers, Boston

About this chapter

Cite this chapter

Greenberg, P.D., Cheever, M.A., Fefer, A. (1983). Therapy of Established Tumors by Adoptive Transfer of T Lymphocytes. In: Herberman, R.B. (eds) Basic and Clinical Tumor Immunology. Cancer Treatment and Research, vol 14. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3873-4_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3873-4_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3875-8

  • Online ISBN: 978-1-4613-3873-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation