Abstract
Renal function is not fully developed at birth. The glomerular filtration rate (GFR) is low and many tubular transport systems are immature (1,2). The coordination of function in different tubular segments is sometimes poorer than in the adult nephron. The low renal functional capacity in the perinatal period is largely attributed to renal structural immaturity (3). One expression of renal immaturity at birth is a limited capacity to regulate sodium balance.
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References
Arant, B.: Developmental patterns of renal functional maturation compared in the human neonate. J. Pediatr. 92: 705, 1978.
Aperia, A., Broberger, O., Elinder, G., Herin, P. and Zetterstrom, R.: Postnatal development of renal function in pre-term and full-term infants. Acta Paediatr. Scand. 70: 183, 1981.
Larsson, L., Aperia, A. and Elinder, G.: Structural and functional development of the nephron. Acta Paediatr. Scand., Suppl.(in press 1982).
Aperia, A., Broberger, O., Herin, P. and Zetterstrom, R.: Sodium excretion in relation to sodium intake and aldosterone excretion in newborn pre-term and full-term infants. Acta Paediatr. Scand. 68: 813, 1979.
Aperia, A., Broberger. O., Thodenius, K. and Zetterstrom, R.: Renal response to an oral sodium load in newborn full-term infants. Acta Paediatr. Scand. 61: 670, 1972.
Day, G.M., Radde, I.E., Balfe, J.W. et al.: Electrolyte abnormalities in very low birthweight infants. Pediat. Res. 10 522, 1976.
Engelke, S.C., Shah, B.L., Vasan, U. et al.: Sodium balance in very low-birth-wight infants. J. Pediatr. 93: 837, 1978.
Aperia, A., Broberger, O., Thodenius, K. and Zetter-strom, R.: Developmental study of the renal response to an oral salt load in pre-term infants. Acta Paediatr. Scand. 63: 517, 1974.
Sulyok, E., Nemeth, M., Tenyi, I. et al.: Postnatal development of renin-angiotensin-aldosterone system. RAAS, in relation to electrolyte balance in prematur infants. Pediatr. Res. 13: 817, 1979.
Schmidt, V. and Horster, M.: Na-K-activated ATPase activity maturation in rabbit nephron segments dissected in vitro. Am. J. Physiol. 233: F55, 1977.
Aperia, A., Larsson, L. and Zetterstrom, R.: Hormonal induction of Na-K-ATPase in developing proximal tubular cells. Am. J. Physiol. 10: F356, 1981.
Guignard, J.P., Torrado, A. and Gautier, E.: Glomerular filtration rate in the first three weeks of life. J. Pediatr. 87: 268, 1975.
Svenningsen, N.: Signle injection of polyfructosan clearance in normal and asphyxiated neonates. Acta Paediatr. Scand. 64: 87, 1975.
Aperia, A. and Elinder, G.: Distal tubular sodium reab- sorption in the developing rat kidney. Am. J. Physiol. 9: F487, 1981.
Aperia, A., Broberger, 0. and Herin, P.: Changes in renal hemodynamics and sodium excretion during saline infusion in lambs. Acta Paediatr. Scand. 94: 442, 1975.
Kleinmann, I.: Renal sodium reabsorption during saline loading and distal blockade in newborn dogs. Am. J. Physiol. 288: 1403, 1975.
Polacek, E., Vocel, J., Neugebauerova, L. et al.: The osmotic concentrating ability in healthy infants and children. Arch. Dis. Child. 40: 291, 1965.
Simmons, M.A., Adcock, E.W., Bard, H. et al.: Hypernatremia and intrarenal hemorrhage in neonates. N. Eng. J. Med. 291: 6, 1974.
Macaulay, D. and Watson, M.: Hypernatraemia in infants as a cause of brain damage. Arch. Dis. Child. 42: 485, 1967.
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© 1983 Martinus Nijhoff Publishers, Boston
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Aperia, A. (1983). Renal Salt Excretion In The Low-Birth-Weight Infant. In: Strauss, J. (eds) Neonatal Kidney and Fluid-Electrolytes. Developments in Nephrology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3870-3_8
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DOI: https://doi.org/10.1007/978-1-4613-3870-3_8
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