Abstract
Calcium requirements for growth and for skeletal mineralization during fetal life and in early postnatal development are substantial. During fetal life, significant active transfer of calcium occurs from mother to fetus via the placenta.1 At birth, the connection between mother, placenta, and infant is severed and the intestinal tract becomes the major organ of calcium acquisition for the infant. Early studies in newborn animals demonstrated increased rates of intestinal calcium absorption compared to adult animals.2 However, recent studies of vitamin D deficient and vitamin D-replete rat pups showed that intestinal calcium transport during the first two weeks of life is not meditated by 1,25-dihydroxyvitamin D as is true for adult animals.3 In these studies, a vitamin D-sensitive intestinal calcium transport system developed late in the suckling and in the early weanling period. In light of developmental changes taking place in the intestinal tract and the apparent lack of absolute dependence on vitamin D mediated intestinal calcium transport in the immediate postnatal period, we began studies on the ontogeny of intestinal calcium transport in utero. This paper reports the results of preliminary experiments carried out in fetal lambs.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Feaster, J.P., Mansard, S.K., Outler, J.C., and Davis, G.K.: Placental transfer of calcium in the rat. J. Nutr. 58: 399–406, 1956.
Younoszai, M.K. and Ghisham, F.K.: In vivo intestinal calcium absorption in infant rats: Influence of methylprednisolone and vitamin D. Proc. Soc. Exp. Biol. Med. 158: 174–178, 1978.
Halloran, B.P. and Deluca, H.F.: Calcium transport in small intestine during early development: Role of vitamin D. Am. J. Physiol (Gastro Intest Liver Physiol) 2: G473–G479, 1980.
Moore, E.,S., DeLannoy, C.W. and Paton, J.B.: The effect of Na2S04 on urinary acidification in the infant fetal lamb. Am. J. Physiol 223: 167, 1972,
Moore, E.S., Langman, C.B., Favus, M.J., Ocampo, M., Loghman-Adham, M. and Coe, F.L.: Role of fetal kidneys in calcium homeostasis in utero. In Vitamin D, Clinical, Biochemical and Clinical Endocrinology of Calcium Metabolism. Norman, A.W., Schaefer, K., Hersath, D.V., and Grigoleit, H.G. (Eds.). Walter De Gruyter, Berlin, 1982. (in press).
Delorne, A.C., Marche, P., and Garel, J.M.: Vitamin D-dependent calcium binding protein. Changes during gestation, prenatal and postnatal development in rats. J. Develop. Physiol Is 181–194, 1979.
Schachter, D. and Rosen, S.M.: Active transport of 45Ca by the small intestine and its dependence on vitamin D. Am. J. Physiol. 196: 357–362, 1959.
Omdahl, J.L. and DeLuca, H.F.: Mediation of calcium adaptation by 1,25-dihydroxycholecalciferol. J. Nutr. 107: 1975–1980, 1977.
Weisman, Y., Harell, A., Edelstein, D., David, M., Spirer, Z. and Golander, A.: 1, 25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 in vitro synthesis by human decidua and placenta. Nature 281: 317–319, 1979.
Ghisham, F.K., Jenkins, J.T. and Younoszai, M.K.: Maturation of calcium transport in the rat small and large intestine. J. Nutr. 110: 1622–1628, 1980.
Batt, E.R. and Schachter, D.: Developmental pattern of some intestinal transport mechanism in newborn rats and mice. Am. J. Physiol. 216: 1064–1068, 1969
Radde, I.C., David, D., Sheepers, J. and McKercher, H. G.: Bidirectional Ca and 32 p fluxes across the small intestine of the young piglet, In Pediatric Diseases Related to Calcium, DeLuca, H.P. and Anast, C.S., ed., Elsevier, New York, 1980, pp. 153–163.
Shaw, J.C.L.: Evidence for defective mineralization in low birth weight infants: The absorption of calcium and fat. Pediatrics 57: 16–25, 1976.
Steichen, J.J., Tsano, R.C., Gratton, T.C., Hamstra, A. and DeLuca, H.F.: Vitamin D homeostasis in the perinatal period. 1,25-dihydroxy- vitamin D in maternal, cord and neonatal blood. N. Eng. J. Med. 302: 315–319, 1980.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Martinus Nijhoff Publishers, Boston
About this chapter
Cite this chapter
Moore, E.S., Langman, C.B., Loghman-Adham, M., Ocampo, M. (1983). Intestinal Calcium Transport In Utero. Clinical Implications for the Newborn Infant. In: Strauss, J. (eds) Neonatal Kidney and Fluid-Electrolytes. Developments in Nephrology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3870-3_1
Download citation
DOI: https://doi.org/10.1007/978-1-4613-3870-3_1
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3872-7
Online ISBN: 978-1-4613-3870-3
eBook Packages: Springer Book Archive