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Pancreatic polypeptide cells

  • Chapter
Ultrastructure of Endocrine Cells and Tissues

Part of the book series: Electron Microscopy in Biology and Medicine ((EMBM,volume 1))

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Abstract

Unlike most established hormones, the pancreatic polypeptides were not isolated due to distinctive physiological activities, but were detected as contaminants during purification of insulin and glucagon from the avian and mammalian pancreas (1,2). Avian pancreatic polypeptide (APP) differs from the mammalian PP’s in 20 of the 36 amino acid positions (2). Therefore, antibodies raised to APP usually do not cross-react with mammalian PP’s and vice versa. Availability of highly specific PP antibodies permitted radioimmunoassay studies showing that APP circulated in blood and occurred in pancreatic extracts of many avian and reptilian species (3). Subsequently, immunocytochemical studies demonstrated the presence of APP in pancreatic endocrine-like cells, different from the B, A and D cells (4). Somewhat later, also mammalian PP’s were localized to secretory granules in distinct endocrine-like cell types (5, 6).

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Author information

Authors and Affiliations

  1. Unit of Histochemistry, University Institute of Pathology, Frederik den V’s vej 11, DK-2100, Copenhagen Ø, Denmark

    Lars-Inge Larsson

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  1. Lars-Inge Larsson
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Editors and Affiliations

  1. Department of Anatomy, Faculty of Medicine, University of Rome, Italy

    P. M. Motta M.D., Ph.D.

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© 1984 Martinus Nijhoff Publishers, Boston, The Hague, Dordrecht, Lancaster

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Larsson, LI. (1984). Pancreatic polypeptide cells. In: Motta, P.M. (eds) Ultrastructure of Endocrine Cells and Tissues. Electron Microscopy in Biology and Medicine, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3861-1_12

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  • DOI: https://doi.org/10.1007/978-1-4613-3861-1_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3863-5

  • Online ISBN: 978-1-4613-3861-1

  • eBook Packages: Springer Book Archive

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