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A Review of Animal Brain Tumor Models that have been used for Therapeutic Studies

  • Chapter
Oncology of the Nervous System

Part of the book series: Cancer Treatment and Research ((CTAR,volume 12))

Abstract

Laboratory investigations of primary human brain tumors have largely depended on the use of animal models. While studies of tumors in animals often lack the precision and elegance of research on the cell biology of individual neoplastic cells, observations on the behavior of in vivo models are more readily applied to clinical problems. The proper experimental use of a well-characterized animal brain tumor model can therefore be a powerful intermediate step in the overall attack on human brain tumors.

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Abbreviations

ACNU:

1-(4-amino-2-methyl-5 -pyrimidinyl)methyl-3-(2-chloroethyl)-3 -nitrosourea

Ara-C:

cytosine arabinoside, NSC-63878

AZQ:

aziridinylbenzoquinone, NSC-182986

BCNU:

1,3-bis(2-chloroethyl)-1-nitrosourea, NSC-409962

CCNU:

1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea, NSC-79037

CPA:

cyclophosphamide, NSC-26271

DAG:

dianhydrogalactitol, NSC-132313

DTIC:

5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide, NSC-45388

5-FU:

5-fluorouracil, NSC-19893

meCCNU:

1-(2-chloroethyl)-3-(4-methyl-cyclohexyl)-l-nitrosourea, NSC-95441

6-MP:

6-mercaptopurine, NSC-755

MTX:

methotrexate NSC-740

PCB:

procarbazine, NSC-77213

PCNU:

1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl)-l-nitrosourea, NSC-95466

6-TG:

6-thioguanine, NSC-752

VCR:

vincristine, NSC-49842

VM-26:

teniposide, NSC-122819

References

  1. Law LW, Dunn TB, Boyle PJ, Miller JH:Observations on the effect of a folic-acid antagonist on transplantable lymphoid leukemias in mice. J Natl Cancer Inst 10:179–192, 1949.

    PubMed  CAS  Google Scholar 

  2. Skipper HE, Schabel FM Jr, Wilcox WS:Experimental evaluation of potential anticancer agents. XXI. Scheduling of arabinosylcytosine to take advantage of its S-phase specificity against leukemia cells. Cancer Chemother Rep 51:125–165, 1967.

    PubMed  CAS  Google Scholar 

  3. Wodinsky I, Kensler CJ, Venditti JM:Comparative kinetics and chemotherapy of the slow growing B16 melanoma and the fast growing L1210 leukemia. Proc Am Assoc Cancer Res 13:8, 1972.

    Google Scholar 

  4. Skipper HE, Schabel FM Jr, Trader MW, Thomson JR:Experimental evaluation of potential anticancer agents. VI. Anatomical distribution of leukemic cells and failure of chemotherapy. Cancer Res 21:1154–1164, 1961.

    PubMed  CAS  Google Scholar 

  5. Chirigos MA, Humphreys SR:Effect of alkyating agents on meningeal leukemia LI210 arising in methotrexate-treated mice. Cancer Res 26:1673–1977, 1966.

    PubMed  CAS  Google Scholar 

  6. Bigner DD, Swenberg JA (eds):Jänish and Schreiber’s Experimental Tumors of the Central Nervous System. Upjohn, Kalmazoo, 1977.

    Google Scholar 

  7. Zimmerman HM:Experimental models of neoplasia in the central nervous system. In:Primary Intracranial Neoplasms. Sher JH, Ford DH (eds), Spectrum Publications, New York, 1979, pp 1–32.

    Google Scholar 

  8. Kleihues P, Bigner DD:Tumors of the nervous system. In:The Molecular Basis of Neuropathology. Thompson RHS, Davison AN (eds), Edward Arnold, London, 1981, pp 81–103.

    Google Scholar 

  9. Seligman AM, Shear MJ:Studies in Carcinogenesis. VIII. Experimental production of brain tumors in mice with methylcholanthrene. Am J Cancer 37:364–395, 1939.

    CAS  Google Scholar 

  10. Zimmerman HM, Arnold H:Experimental brain tumors. I. Tumors produced with methylcholanthrene. Cancer Res 1:919–938, 1941.

    CAS  Google Scholar 

  11. Zimmerman HM:The nature of glimas as revealed by animal experimentation. Am J Pathol 31:1–29, 1955.

    PubMed  CAS  Google Scholar 

  12. Ausman JI, Shapiro WR, Rail DP:Studies on the chemotherapy of experimental brain tumors:development of an experimental model. Cancer Res 30:2394–2400, 1970.

    PubMed  CAS  Google Scholar 

  13. Sugiura K:Tumor transplantation. In:Methods of Animal Experimentation, vol. 2, Gay Wi (ed), Academic Press, New York, 1965, pp 171–222.

    Google Scholar 

  14. Shapiro WR:Chemotherapy of brain tumors:results in an experimental murine glioma. In:Models of Human Neurological Diseases, Klawans HL (ed), Excerpta Medica, Amsterdam, 1974, pp 121–143.

    Google Scholar 

  15. Rubinstein LJ:Correlation of animal brain tumor models with human neuro-oncology. Nat Cancer Inst Monogr 46:43–49, 1977.

    PubMed  CAS  Google Scholar 

  16. Rubin R, Sutton CH, Zimmerman HM:Experimental ependymoblastoma (fine structure). J Neuropathol Exp Neurol 27:421–438, 1968.

    Article  Google Scholar 

  17. Rubin RC, Ames RP:Mammary tumor virus in experimental ependymoblastoma. Prog neuropathol 2:335–349, 1973.

    Google Scholar 

  18. Hasegawa H, Shapiro WR, Posner JB, Basler G:Effect of 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride on experimental brain tumors. Cancer Res 39:2687–2690, 1979.

    PubMed  CAS  Google Scholar 

  19. Albright L, Madigan JC, Gaston MR, Houchens DP:Therapy in an intracerebral murine glioma model, using Bacillus Calmette-Guerin, neuraminidase-treated tumor cells, and 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea. Cancer Res 35:658–665, 1975.

    PubMed  CAS  Google Scholar 

  20. Levin VA, Chadwick M:Distribution of 5-fluorouracil-2-14C and its metabolites in a murine glioma. J Natl Cancer Inst 49:1577–1584, 1972.

    PubMed  CAS  Google Scholar 

  21. Levin VA, Clancy TP, Ausman JI, Rail DP:Uptake and distribution of 3H-methotrexate by the murine ependymoblastoma. J Natl Cancer Inst 48:875–883, 1972.

    PubMed  CAS  Google Scholar 

  22. Shapiro WR:The effect of chemotherapeutic agents on the incorporation of DNA precursors by experimental brain tumors. Cancer Res 32:2178–2185, 1972.

    PubMed  CAS  Google Scholar 

  23. Tator CH:Retention of tritiated methotrexate in a transplantable mouse glioma. Cancer Res 36:3058–3066, 1976.

    PubMed  CAS  Google Scholar 

  24. Scheinberg LC, Suzuki K, Edelman F, Davidoff LM:Studies in immunization against a transplantable cerebral mouse glioma. J Neurosurg 20:312–317, 1963.

    Article  PubMed  CAS  Google Scholar 

  25. Scheinberg LC, Levine MC, Suzuki K, Terry RD:Induced host resistance to a transplantable mouse glioma. Cancer Res 22:67–72, 1962.

    PubMed  CAS  Google Scholar 

  26. Druckrey H, Ivankovic S, Preussmann R, Zulch KJ, Mennel HD:Selective induction of malignant tumors of the nervous system by resorptive carcinogens. In:The Experimental Biology of Brain Tumors, Kirsch WM, Grossi-Paoletti E, Paoletti P (eds), Charles C. Thomas, Springfield, 1972, pp 85–147.

    Google Scholar 

  27. Druckrey H, Ivankovic S, Preussmann R:Teratogenic and carcinogenic effects in the offspring after a single injection of ethylnitrosourea to pregnant rats. Nature 210:1378–1379, 1966.

    Article  PubMed  CAS  Google Scholar 

  28. Swenberg JA, Koestner A, Wechsler W, Denlinger RH:Quantitative aspects of transplacental tumor induction with ethylnitrosourea in rats. Cancer Res 32:2656–2660, 1972.

    PubMed  CAS  Google Scholar 

  29. Rubinstein LJ:Current concepts in neuro-oncology. Adv Neurol 15:1–25, 1976.

    PubMed  CAS  Google Scholar 

  30. Jones EL, Searle CE, Smith WT:Tumours of the nervous system induced in rats by the neonatal administration of n-ethyl-n-nitrosourea. J Path 1109:123–139, 1973.

    Google Scholar 

  31. Laerum OD, Rajewsky MF:Sequential phenotypic changes in neural target cell populations. In:Biology of Brain Tumors, Laerum OD, Bigner DD, Rajewsky MF (eds), UICC, Geneva, 1978, pp 129–141.

    Google Scholar 

  32. Haugen A:Chemical carcinogenesis and ultrastructure of fetal brain cells in culture. Thesis, University of Bergen Press, Bergen, 1978.

    Google Scholar 

  33. Allen N:Experimental therapy of brain tumors. In:Neurochemistry and Clinical Neurology, Battistin L, Hashim G, Lajtha A (eds), A.R. Liss, New York, 1980, pp 441–454.

    Google Scholar 

  34. Spence AM, Geraci JP:Combined cyclotron fast-neutron and BCNU therapy in a rat brain- tumor model. J Neurosurg 54:461–467, 1981.

    Article  PubMed  CAS  Google Scholar 

  35. Swenberg JA:Treatment of primary brain tumors with CCNU. Proc Am Assoc Cancer Res 14:25, 1973.

    Google Scholar 

  36. Denlinger RH, Nichol CA, Cavallito JC, Sigel CW:Chemotherapy of primary brain tumors in rats with two lipid soluble diamino pyrimidine folate antagonists. Proc Am Assoc Cancer Res 17:95, 1976.

    Google Scholar 

  37. Herschmann HR:Characteristics of cell culture lines derived from chemically induced neural tumors. In:Biology of Brain Tumors, Laerum OD, Bigner DD, Rajewsky MF (eds), UICC, Geneva, 1978, pp 172–183.

    Google Scholar 

  38. Cravioto H, Ransohoff J:Nitrosourea induced gliomas:tissue culture and transplantation studies. In:Experimentelle Neuro-Onkologie, Schreiber D, Janisch W (eds), VEB Broschuren- verarbeitung, Leipzig, East Germany, 1975.

    Google Scholar 

  39. Chelmicka-Schorr E, Arnason BGW, Holshouser SJ:C-6 glioma growth in rats:suppression with a β-adrenergic agonist and a phosphodiesterase inhibitor. Ann Neurol 8:447–449, 1980.

    Article  PubMed  CAS  Google Scholar 

  40. Benda P, Someda K, Messer J, Sweet NH:Morphological and immunochemical studies of rat glial tumors and clonal strains propagated in culture. J Neurosurg 34:310–323, 1971.

    Article  PubMed  CAS  Google Scholar 

  41. Schmidek HH, Nielsen SL, Schiller AL, Messer J:Morphological studies of rat brain tumors induced by N-nitrosomethylurea. J Neurosurg 34:335–340, 1971.

    Article  PubMed  CAS  Google Scholar 

  42. Wheeler KT, Barker M, Wallen CA, Kimler BF, Henderson SD:Evaluation of 9L as a brain tumor model. In:Methods in Tumor Biology:Tissue Culture and Animal Tumor Models, Sridner R (ed), Marcel Dekker, New York, in press.

    Google Scholar 

  43. Barker M, Hoshino T, Gurcay O, Wilson CB, Nielsen SL, Downie R, Eliason J:Development of an animal brain tumor model and its response to therapy with 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Res 33:976–986, 1973.

    PubMed  CAS  Google Scholar 

  44. Weizaecker M, Deen DF, Rosenblum ML, Hoshino T, Gutin PH, Barker M:The 9L rat brain tumor:description and application of an animal model. J Neurol 224:183–192, 1981.

    Article  Google Scholar 

  45. Deen DF, Hoshino T, Williams ME, Muraoka I, Kuebel KD, Barker M:Development of a 9L rat brain tumor cell multicellular spheroid system and its response to 1,3-bis(2-chloroethyl)-1-nitrosourea and radiation. J Natl Cancer Inst 64:1373–1382, 1980.

    PubMed  CAS  Google Scholar 

  46. Wheeler KT Jr, Kaufman K, Feldstein M:Response of a rat brain tumor to fractionated therapy with low doses of BCNU and irradiation. Int J Radiat Oncol Biol Phys 5:1553–1557, 1979.

    PubMed  Google Scholar 

  47. Levin VA, Freeman-Dove M, Landahl HD:Permeability characteristics of brain adjacent to tumors in rats. Arch Neurol 32:785–791, 1975.

    PubMed  CAS  Google Scholar 

  48. Groothuis DR, Fischer JM, Vick NA, Bigner DD:Comparative permeability of different glioma models to horseradish peroxidase. Cancer Treat Rep, 65 (suppl. 2):13–18, 1981.

    PubMed  CAS  Google Scholar 

  49. Groothuis DR, Fischer JM, Lapin G, Bigner DD, Vick NA:Permeability of different ex¬perimental brain tumor models to horseradish peroxidase. J Neuropath Exp Neurol 41:164–185, 1982.

    Article  PubMed  CAS  Google Scholar 

  50. Vasquez-Lopez E:On the growth of Rous sarcoma inoculated into the brain. Am J Cancer 26:29–55, 1936.

    Google Scholar 

  51. Yung WK, Blank WK, Vick NA, Schwartz NA:“Glioblastoma.” Induction of a reproducible autochthonous tumor in rat brains with murine sarcoma virus. Neurol 36:76–83, 1976.

    Google Scholar 

  52. Johnson L Jr, Wolfe LG, Whisler WW, Norton T, Thakkar B, Deinhardt F:Induction of gliomas in marmosets by Simian sarcoma virus, type 1 (SSV-1). Proc Am Assoc Cancer Res 16:119, 1975.

    Google Scholar 

  53. Walker DL, Padgett BL, ZuRhein GM, Albert AE:Human papovavirus (JC):induction of brain tumors in hamsters. Science 181:674–676, 1973.

    Article  PubMed  CAS  Google Scholar 

  54. Rieth KG, KiChiro G, London WT, Sever JL, Houff SA, Kornblith PL, McKeever PE, Buonomo C, Padgett BL, Walker DL:Experimental gliomas in primates:a computed tomography model. J Comput Assist Tomog 4:285–290, 1980.

    Article  CAS  Google Scholar 

  55. Bigner DD:Role of viruses in the causation of neural neoplasia. In:Biology of Brain Tumors, Laerum OD, Bigner DD, Rajewsky MF (eds), UICC, Geneva, 1978, pp 85–111.

    Google Scholar 

  56. Bigner DD, Pegram CN:Virus-induced experimental brain tumors and putative associations of viruses with human brain tumors:a review. Adv Neurol 15:57–83, 1976.

    PubMed  CAS  Google Scholar 

  57. Rabotti GF, Raine WA:Brain tumors induced in hamsters inoculated intracerebrally at birth with Rous sarcoma virus. Nature 204:898–899, 1964.

    Article  PubMed  CAS  Google Scholar 

  58. Rabotti GF, Grove AS Jr, Sellers RL, Anderson WR:Induction of multiple brain tumors (gliomas and leptomeningeal sarcomata) in dogs by Rous sarcoma virus. Nature 209:884–886, 1966.

    Article  PubMed  CAS  Google Scholar 

  59. Vick NA, Bigner DD, Kvedar JP:The fine structure of canine gliomas and intracranial sarcomas induced by the Schmidt-Ruppin strain of the Rous sarcoma virus. J Neuropath Exp Neurol 30:354–367, 1971.

    Article  PubMed  CAS  Google Scholar 

  60. Copeland DD, Vogel FS, Bigner DD:The induction of intracranial neoplasms by the inoculation of avian sarcoma virus in perinatal and adult rats. J Neuropath Exp Neurol 34:340–358, 1975.

    Article  PubMed  CAS  Google Scholar 

  61. Bigner DD, Self DJ, Frey J, Ishizaki R, Langlois AJ, Swenberg JA:Refinement of the avian oncornavirus-induced primary rat brain tumor model for therapeutic screening. Ree Res Cancer Res 51:20–34, 1975.

    Google Scholar 

  62. Wilfong RF, Bigner DD, Self DJ:Brain tumor types induced by the Schmidt-Ruppin strain of Rous sarcoma virus in inbred Fischer rats. Acta Neuropath 25:196–206, 1973.

    Article  PubMed  CAS  Google Scholar 

  63. Copeland DD, Bigner DD:Glial-mesenchymal tropism of in vivo avian sarcoma virus neuro- on-cogenesis in rats. Acta Neuropath 41:23–25, 1978.

    Article  PubMed  CAS  Google Scholar 

  64. Copeland DD, Bigner DD:Influence of age at inoculation on avian oncornavirus-induced brain tumor incidence, tumor morphology, and postinoculation survival in F344 rats. Cancer Res 37:1657–1661, 1977.

    PubMed  CAS  Google Scholar 

  65. Bigner DD, Kvedar JP, Shaffer TC, Vick NA, Engel WK, Day ED:Factors influencing the cell type of brain tumors induced in dogs by Schmidt-Ruppin Rous sarcoma virus. J Neuropath Exp Neurol 31:583–595, 1972.

    Article  PubMed  CAS  Google Scholar 

  66. Bigner DD, Pegram CN, Vick NA, Copeland DD, Swenberg JA:Characterization of the avian sarcoma virus induced mammalian brain tumors model for immunologic and chemotherapeutic studies. Vllth International Congress of Neuropathology. Excerpta Medica, Amsterdam, 1975, pp 445–451.

    Google Scholar 

  67. Burger PC, Bigner DD, Self DJ:Morphologic observations of brain tumors in PD4 hamsters induced by four strains of avian sarcoma virus. Acta Neuropathol 26:1–21, 1973.

    Article  PubMed  CAS  Google Scholar 

  68. Copeland DD, Talley FA, and Bigner DD:The fine structure of intracranial neoplasms induced by the inoculation of avian sarcoma virus in neonatal and adult rats. Am J Pathol 83:149–176, 1976.

    PubMed  CAS  Google Scholar 

  69. Bigner DD, Vick NA, Kvedar JP, Mahaley MS Jr, and Day ED:Virus-cell relationships in dog brain tumors induced with Schmidt-Ruppin Rous Sarcoma virus. Progr Exp Tumor Res 17:40–58, 1972.

    PubMed  CAS  Google Scholar 

  70. Vick NA, Bigner DD:Microvascular abnormalities in virally-induced canine brain tumors:structural bases for altered blood-brain barrier function. J Neurol Sei 17:29–39, 1972.

    Article  CAS  Google Scholar 

  71. Groothuis DR, Molnar P, Blasberg R, Fenstermacher J, Patlak C, Bigner DD, Fischer J, Vick N:Quantitative autoradiographic measurements of blood flow and permeability in virally induced gliomas. Neurol 31, Part 2:44, 1981 (abstract).

    Google Scholar 

  72. Pasternak JF, Groothuis DR, Fischer JM, Bigner DD, Vick NA:Topologic variability of cellular proliferation in experimental rat gliomas. Neurol 31, Part 2:44, 1981 (abstract).

    Google Scholar 

  73. Roszman TL, Brooks WH, Markesbery WR, Bigner DD:General immunocompetence of rats bearing avian sarcoma virus-induced intracranial tumors. Cancer Res 38:74–77, 1978.

    PubMed  CAS  Google Scholar 

  74. Adams DO, Gilbert RW, Bigner DD:Cellular immunity in rats with primary brain tumors:inhibition of macrophage migration by soluble extracts of avian sarcoma virus-induced tumors. J Natl Cancer Inst 56:1119–1123, 1976.

    PubMed  CAS  Google Scholar 

  75. Meyers ME, Roszman TL, Brooks WH, Bigner DD:Experimental allergic encephalomyelitis in rats with primary gliomas induced with avian sarcoma virus. Fed Proc 37:413, 1978.

    Google Scholar 

  76. Greene HSN, Arnold H:The homologous and heterologous transplantation of brain and brain tumors. J Neurosurg 2:315–331, 1945.

    Article  Google Scholar 

  77. Greene HSN:The transplantation of human brain tumors to the brains of laboratory animals. Cancer Res 13:422–426, 1953.

    PubMed  CAS  Google Scholar 

  78. Wilson CB, Barker M:Intrathecal transplantation of human neural tumors to the guinea pig. J Natl Cancer Inst 41:1229–1240, 1968.

    PubMed  CAS  Google Scholar 

  79. Pantelouris EM:Absence of thymus in a mouse mutant. Nature 217:370–371, 1968.

    Article  PubMed  CAS  Google Scholar 

  80. Giovanella BC, Stehlin JS Jr, Williams LJ Jr, Lee S-S, Shepard RC:Heterotransplantation of human cancers into nude mice:a model system for human cancer chemotherapy. Cancer 42:2269–2281, 1978.

    Article  PubMed  CAS  Google Scholar 

  81. Povlsen CO, Visfeldt J, Rygaard J, Jensen G:Growth patterns and chromosome constitutions of human malignant tumours after long-term serial transplantation in nude mice. Acta Path Microbiol Scand Sect A 83:709–716, 1975.

    CAS  Google Scholar 

  82. Fogh J, Tiso J, Orfeo T, Sharkey FE, Daniels WP, Fogh JM:Thirty-four lines of six human tumor categories established in nude mice. JNCI 64:745–751, 1980.

    PubMed  CAS  Google Scholar 

  83. Bigner DD, Markesbery WR, Pegram CN, Westermark B, Ponten J:Progressive neoplastic growth in nude mice of cultured cell lines derived from anaplastic human gliomas. J Neuropathol Exp Neurol 36:593, 1977.

    Article  Google Scholar 

  84. Bullard DE, Schold SC Jr, Bigner SH, Bigner DD:Growth and chemotherapeutic response in athymic mice of tumors arising from human glioma-derived cell lines. J Neuropath Exp Neurol 40:410–427, 1981.

    Article  PubMed  CAS  Google Scholar 

  85. Wara WM, Begg A, Phillips TL, Rosenblum ML, Vasquez D, Wilson CB:Growth and treatment of human brain tumors in nude mice—preliminary communication. In:The Use of Athymic (Nude) Mice in Cancer Research, Houchens DP, Ovejera AA (eds), Gustav Fischer, New York, 1978, pp 251–256.

    Google Scholar 

  86. Rana MW, Pinkerton H, Thornton H, Nagy D:Heterotransplantation of human glioblastoma multiforme and meningioma to nude mice. Proc Soc Exp Biol Med 155:85–88, 1977.

    PubMed  CAS  Google Scholar 

  87. Reid LM, Holland J, Jones C, Wolf B, Niwayama G, Williams R, Kaplan NO, Sato G:Some of the variables affecting the success of transplantation of human tumors into the athymic nude mouse. In:The Use of Athymic (Nude) Mice in Cancer Research, op. cit., pp 107–121.

    Google Scholar 

  88. Shapiro WR, Basier GA, Chernik NL, Posner JB:Human brain tumor transplantation into nude mice. J Natl Cancer Inst 62:447–453, 1979.

    PubMed  CAS  Google Scholar 

  89. Schold SC Jr, Bullard DE, Bigner SH, Jones TR, Bigner DD:Growth, morphology, and serial transplantation of anaplastic human gliomas in athymic mice. J Neuro-Oncology (in press).

    Google Scholar 

  90. Jones TR, Bigner SH, Schold SC Jr, Eng LF, Bigner DD:Anaplastic human gliomas grown in athymic mice:morphology and glial fibrillary acidic protein expression. Am J Pathol 105:316–327, 1981.

    PubMed  CAS  Google Scholar 

  91. Schabel FM Jr, Johnston TP, McCaleb GS, Montgomery JA, Laster WR, Skipper HE:Experimental evaluation of potential anticancer agents. VIII. Effects of certain nitrosoureas on intracerebral L1210 leukemia. Cancer 23:725–733, 1963.

    CAS  Google Scholar 

  92. Khan AH, Driscoll JS:Potential central nervous system antitumor agents. Aziridinylbenzo- quinones 1. J Med Chem 19:313–317, 1976.

    Article  PubMed  CAS  Google Scholar 

  93. Schabel FM Jr, Laster WR Jr, Trader MW, Corbett TH, Griswold DP Jr:Combination chemotherapy with nitrosoureas plus other anticancer drugs against animal tumors. In:Nitrosoureas—Current Status and New Developments, Prestayko AW, Crooke ST, Baker LH, Carter SK, Schein PS, (eds), New York, Academic Press, 1981, pp 9–26.

    Google Scholar 

  94. Eagan RT, Childs DS Jr, Layton DD Jr, Laws ER Jr, Bisel HF, Holbrook MA, Fleming TR:Dianhydrogalactitol and radiation therapy:treatment of supratentorial glioma. J Am Med Assoc 241:2046–2050, 1979.

    Article  CAS  Google Scholar 

  95. Green SB, Byar DP, Walker MD, Pistenma DA, Alexander E Jr, Batzdorf U et al.:Comparisons of carmustine, procarbazine, and high-dose methylprednisolone as additions to surgery and radiotherapy for the treatment of malignant glioma. Cancer Clin Trials, (in press).

    Google Scholar 

  96. Shapiro WR, Ausman JI, Rail DP:Studies on the chemotherapy of experimental brain tumors:evaluation of 1,3-bis(2-chloroethyl)-1-nitrosourea, cyclophosphamide, mithramycin, and methotrexate. Cancer Res 30:2401–2413, 1970.

    PubMed  CAS  Google Scholar 

  97. Shapiro WR:Studies on the chemotherapy of experimental brain tumors:evaluation of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, vincristine, and 5-fluorouracil. J Natl Cancer Inst 46:359–368, 1971.

    PubMed  CAS  Google Scholar 

  98. Geran RI, Congleton GF, Dudeck LE, Abbott BJ, Gargus JL:A mouse ependymoblastoma as an experimental model for screening potential antineoplastic drugs. Cancer Chemother Rep Part 2, 4:53–87, 1974.

    Google Scholar 

  99. Levin VA, Wilson CB:Correlations between experimental chemotherapy in the murine glioma and efectiveness of clinical therapy regimens. Cancer Chemother Pharmacol 1:41–48, 1978.

    PubMed  CAS  Google Scholar 

  100. Laurent G, Dewerie-Vanhouche J, Machin D, Hildebrand J:Inhibition of RNA synthesis in murine ependymoblastoma by the combination of amphotericin B and 1-(2-chloroethyl)-3-cyclo- hexyl-1-nitrosourea. Cancer Res 40:939–942, 1980.

    PubMed  CAS  Google Scholar 

  101. Muller PJ, Tator CH:The effect of amphotericin B on the survival of brain tumor-bearing mice treated with CCNU. J Neurosurg 49:579–588, 1978.

    Article  PubMed  CAS  Google Scholar 

  102. Edelman FL, Aleu F, Scheinberg LC, Evans JC, Davidoff LM:Effect of irradiation on the growth of intracerebral gliomas in mice. J Neuropath Exp Neurol 23:1–17, 1964.

    Article  PubMed  CAS  Google Scholar 

  103. Levin VA, Kabra P:Effectiveness of the nitrosoureas as a function of their lipid solubility in the chemotherapy of experimental rat brain tumors. Cancer Chemother Rep 58:787–792, 1974.

    PubMed  CAS  Google Scholar 

  104. Tel E, Barker M, Levin VA, Wilson CB:Effect of combined surgery and BCNU (NSC-409962) on an animal brain tumor model. Cancer Chemother Rep 58:627–631, 1974.

    PubMed  CAS  Google Scholar 

  105. Levin VA, Freeman-Dove MA, Maroten CE:Dianhydrogalactitol (NSC-132313):pharmacokinetics in normal and tumor-bearing rat brain and antitumor activity against three intracerebral rodent tumors. J Natl Cancer Inst 56:535–539, 1976.

    PubMed  CAS  Google Scholar 

  106. Rosenblum ML, Wheeler KT, Wilson CB, Barker M, Knebel KD:In vitro evaluation of in vivo brain tumor chemotherapy with 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Res 35:1387–1391, 1975.

    PubMed  CAS  Google Scholar 

  107. Rosenblum ML, Deen DF, Hoshino T, Dougherty DA, Williams ME, Wilson CB:Comparison of clonogenic cell assays after in vivo and in vitro treatment of 9L gliosarcoma. Br J Cancer 41, Suppl IV:307–308, 1980.

    Google Scholar 

  108. Rosenblum ML, Hoshino T, Levin VA, Wilson CB:Planning of brain tumor therapy based on laboratory investigations:sequential BCNU 5-FU treatment of malignant gliomas. Presented at the 50th meeting of the American Association of Neurological Surgeons, Boston, April 5–9, 1981.

    Google Scholar 

  109. Leith JT, Schilling WA, Wheeler KT:Cellular radiosensitivity of a rat brain tumor. Cancer 35:1545–1550, 1975.

    Article  PubMed  CAS  Google Scholar 

  110. Barker M, Deen DF, Baker DG:BCNU and x-ray therapy of intracerebral 9L rat tumors. Int J Radiat Oncol Biol Phys 5:1581–1583, 1979.

    PubMed  CAS  Google Scholar 

  111. Wheeler KT, Kaufman K:Influence of fractionation schedules on the response of a rat brain tumor to therapy with BCNU and radiation. Int J Radiat Oncol Biol Phys 6:845–849, 1980.

    Article  PubMed  CAS  Google Scholar 

  112. Henderson SD, Kimler BF, Morantz RA:Radiation therapy of 9L rat brain tumors. Int J Rad Oncol Biol Phys 7:497–502, 1981.

    Article  CAS  Google Scholar 

  113. Reddy EK, Kimler BF, Henderson SD, Morantz RA:Combinations of misonidazole and radiation therapy in a rat brain tumor (9L) system. In:Radiation Sensitizers, Brady LW (ed), Masson Publishing, USA, New York, 1980, pp 457–460.

    Google Scholar 

  114. Wheeler KT, Deen DF, Wilson CB, Williams ME, Sheppard S:BCNU-modification of the in vitro radiation response in 9L brain tumor cells of rats. Int J Radiat Oncol Biol Phys 2:79–88, 1977.

    PubMed  CAS  Google Scholar 

  115. Wheeler KT, Wallen CA:Is cell survival a determinant of the in situ response of 9L tumors? Br J Cancer 41, Suppl IV:299–303, 1980.

    Google Scholar 

  116. Merker PC, Wodinsky I, Geran RI:Review of selected experimental brain tumor models used in chemotherapy experiments. Cancer Chemother Rep Part 1, 59:729–736, 1975.

    CAS  Google Scholar 

  117. Steinbok P, Mahaley MS Jr, U R, Varia MA, Lipper S, Mahaley J, Dalzell JG, Bigner DD:Treatment of autochthonous rat brain tumors with fractionated radiotherapy:the effects of graded radiation doses and of combined therapy with BCNU or steroids. J Neurosurg 53:68–72, 1980.

    Article  PubMed  CAS  Google Scholar 

  118. Steinbok P, Mahaley MS Jr, U R, Zinn DC, Lipper S, Mahaley JL, Bigner DD:Synergism between BCNU and irradiation in the treatment of anaplastic gliomas:an in vivo study using the avian sarcoma virus-induced glioma model. J Neurosurg 51:581–586, 1979.

    Article  PubMed  CAS  Google Scholar 

  119. Mahaley MS Jr, Gentry RE, Bigner DD:Immunobiology of primary intracranial tumors. Part 2:The evaluation of chemotherapy and immunotherapy protocols using the avian sarcoma virus glioma model. J Neurosurg 47:35–43, 1977.

    Article  PubMed  Google Scholar 

  120. Mahaley MS Jr, Steinbok P, Aronin P, Dudka L, Zinn D:Immunobiology of primary intracranial tumors. Part 4:Levamisole as an immune stimulant in patients and in the ASV glioma model. J Neurosurg 54:220–227, 1981.

    Article  PubMed  Google Scholar 

  121. Shapiro WR, Basier GA:Chemotherapy of human brain tumors transplanted into nude mice. In:Multidisciplinary Aspects of Brain Tumor Therapy, Paoletti P, Walker MD, Butti G, Knerich R (eds), Elsevier/North Holland, Amsterdam, 1979, pp 309–316.

    Google Scholar 

  122. Houchens DP, Ovejera AA, Riblet SM:Human brain tumor xenografts is nude mice as a chemotherapy and/or immunotherapy model. Eur J Cancer, in press.

    Google Scholar 

  123. Slagel DE, Feola J, Houchens DP, Ovejera AA:Combined modality treatment using radiation and/or chemotherapy in an athymic (nude) mouse-human medulloblastoma and glioblastoma xenograft model. Cancer Research 42:812–816, 1982.

    PubMed  CAS  Google Scholar 

  124. Walker MD, Green SB, Byar DP, Alexander E Jr, Batzdorf U, Brooks WH et al.:Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med 303:1323–1329, 1980.

    Article  PubMed  CAS  Google Scholar 

  125. Wodinsky I, Merker PC, Venditti JM:Responsiveness to chemotherapy of mice with LI210 lymphoid leukemia implanted in various anatomic sites. J Natl Cancer Inst 59:405–408, 1977.

    Google Scholar 

  126. Shapiro WR:The chemotherapy of intracerebral vs. subcutaneous murine gliomas:a comparative study of the effect of VM-26. Arch Neurol 30:222–226, 1974.

    PubMed  CAS  Google Scholar 

  127. Levin VA, Crafts D, Wilson CB, Kabra P, Hansch C, Boldrey E, Enot J, Neely M:Imidazole carboxamides:relationship of lipophilicity to activity against intracerebral murine glioma 26 and preliminary phase II clinical trial of 5-(3,3-bis(2-chloroethyl)-1-triazeno)imidazole-4-carboxa- mide (NSC-82196) in primary and secondary brain tumors. Cancer Chemother Rep, Part 1, 59:327–331, 1975.

    PubMed  CAS  Google Scholar 

  128. Basler GA, Shapiro WR:Comparison of 2,2’-anhydro-1-b-D-arabinofuranosyl-5-fluorocytosine and cytosine arabinoside in the treatment of murine brain tumor. Cancer Treat Rep 60:875–879, 1979.

    Google Scholar 

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Authors
  1. S. Clifford Schold Jr.
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  2. Darell D. Bigner
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Editors and Affiliations

  1. National Institutes of Health, NINCDS, STP, Federal 8A-08, Bethesda, MD, 20205, USA

    Michael D. Walker M.D.

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© 1983 Martinus Nijhoff Publishers, Boston/The Hague/Dordrecht/Lancaster

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Schold, S.C., Bigner, D.D. (1983). A Review of Animal Brain Tumor Models that have been used for Therapeutic Studies. In: Walker, M.D. (eds) Oncology of the Nervous System. Cancer Treatment and Research, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3858-1_2

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