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Growth of Gynecologic Neoplasms in Tissue Culture and as Heterografts

  • Chapter
Gynecologic Oncology

Part of the book series: Cancer Treatment and Research ((CTAR,volume 10))

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Abstract

A major challenge to investigators studying human tumors is the development of a laboratory model in which the behavior and response of the tumor is the same or similar to that of the patient. Since the early part of this century [1,2], tissue culture of human cells, both benign and malignant, has been one of the approaches used to understand tumor behavior. The difficulties inherent in tissue culture techniques, particularly in the days before antibiotics were available, prompted investigators to look further, to the study of animal tumor model systems. Recognition of immunologically privileged sites in laboratory animals permitted the first successful growth of human tumors in another species (‘heterografts’) [37–41]. In addition to the use of such immunoprivileged sites for tumor transplantation, methods resulting in total body immunosuppression could be added to enhance the probability of tumor growth in a foreign host [42–45]. It was not until the discovery of the athymic nude mouse, however, that a widespread use of animal heterografts for the study of human cancers was possible [50, 51].

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Authors
  1. Charles E. Welander
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  2. John L. Lewis Jr.
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Editors and Affiliations

  1. Harvard Medical School, Brigham and Women’s Hospital, Boston, Massachusetts, USA

    C. Thomas Griffiths M.D.

  2. Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA

    Arlan F. Fuller Jr. M.D.

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© 1983 Martinus Nijhoff Publishers, Boston

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Welander, C.E., Lewis, J.L. (1983). Growth of Gynecologic Neoplasms in Tissue Culture and as Heterografts. In: Griffiths, C.T., Fuller, A.F. (eds) Gynecologic Oncology. Cancer Treatment and Research, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3852-9_10

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  • DOI: https://doi.org/10.1007/978-1-4613-3852-9_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3854-3

  • Online ISBN: 978-1-4613-3852-9

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