Intracavitary Hyperthermia and Intra-arterial Chemotherapy

  • Stephen C. Jacobs
Part of the Developments in Oncology book series (DION, volume 26)

Abstract

Intra-arterial (IA) chemotherapy improves the therapeutic index of administered agents. This conference has addressed this issue in great depth, and I would like to comment only on the agents doxorubicin (ADR) and cis-diamminedichloroplatinum II (CDDP). ADR has been found to be more effective in the rabbit VX-2 tumor when given IA than IV.(1) ADR IA infusion of the dog limb results in greater normal tissue uptake of ADR than IV infusion.(2) Clinical IA infusions of ADR alone have shown promise for a number of tumors.(3,4) The long plasma half-life of ADR, however, would favor the IV use of this agent.(5)

Keywords

Permeability Platinum Oncol Sarcoma Doxorubicin 

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Copyright information

© Martinus Nijhoff Publishers, Boston 1984

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  • Stephen C. Jacobs

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