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Intracavitary Hyperthermia and Intra-arterial Chemotherapy

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Intra-Arterial and Intracavitary Cancer Chemotherapy

Part of the book series: Developments in Oncology ((DION,volume 26))

Abstract

Intra-arterial (IA) chemotherapy improves the therapeutic index of administered agents. This conference has addressed this issue in great depth, and I would like to comment only on the agents doxorubicin (ADR) and cis-diamminedichloroplatinum II (CDDP). ADR has been found to be more effective in the rabbit VX-2 tumor when given IA than IV.(1) ADR IA infusion of the dog limb results in greater normal tissue uptake of ADR than IV infusion.(2) Clinical IA infusions of ADR alone have shown promise for a number of tumors.(3,4) The long plasma half-life of ADR, however, would favor the IV use of this agent.(5)

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Authors
  1. Stephen C. Jacobs M.D.
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Editors and Affiliations

  1. Division of Hematology/Oncology Department of Medicine, University of California, San Diego School of Medicine, San Diego, La Jolla, California, 92093, USA

    Stephen B. Howell

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© 1984 Martinus Nijhoff Publishers, Boston

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Jacobs, S.C. (1984). Intracavitary Hyperthermia and Intra-arterial Chemotherapy. In: Howell, S.B. (eds) Intra-Arterial and Intracavitary Cancer Chemotherapy. Developments in Oncology, vol 26. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3843-7_24

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  • DOI: https://doi.org/10.1007/978-1-4613-3843-7_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3845-1

  • Online ISBN: 978-1-4613-3843-7

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