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Allogeneic Bone Marrow Transplantation

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Transplantation and Blood Transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 10))

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Abstract

Transplantation of allogeneic bone marrow is increasingly utlized as a modality of treatment for aplastic anemia and leukemia. Patients with these disorders are usually immunocompetent and are able to reject grafts. It is therefore necessary to immunosuppress these patients in preparation for transplantation from donors other than genetically identical twins.

Supported by grants CA-23175, from the National Cancer Institute and by grant RR-865 from, the Public Health Service. Dr. Champlin is a recipient of a New Investigator Research Award, National Institute of Arthritis, Diabetes and Kidney Disease. Dr. Gale is the Meyerhoff Visiting Scientist of the Weizmann Institute of Science.

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References

  1. Bortin MM, Gale RP, Rinrai AA. Bone Marrow Transplantation Registry. Allogeneic bone marrow transplantation in 144 patients with severe aplastic anemia. JAMA 1981; 245: 1132–9.

    Article  CAS  PubMed  Google Scholar 

  2. Gale RP. Clinical trials of bone marrow transplantation in leukemia. In: Gale RP, Fox CF, eds. The biology of bone marrow transplantation. New York Academic Press 1980: 11–28.

    Google Scholar 

  3. Sparkes MC, Crist ML, Sparkes RS, Gale RP, Feig SA. Gene markers in human bone marrow transplantation. Vox Sang 1977; 33: 202–5.

    Article  CAS  PubMed  Google Scholar 

  4. Grebe SC, Streilein JW. Graft versus host reactions: A review. Adv Immunol 1976; 22: 119–221.

    Article  CAS  PubMed  Google Scholar 

  5. Von Bekkum DW. Immunologic basis of graft versus host disease. In: Gale RP, Fox DF, eds. The biology of bone marrow transplantation. New York Academic Press 1980: 175–94.

    Google Scholar 

  6. Glucksberg H, Storb R, Fefer A, et al. Clinical graft versus host disease in human recipients of marrow from HLA-matched sibling donors. Transplantation 1974; 18: 285–304.

    Article  Google Scholar 

  7. Slavin RE, Santos GW. The graft versus host reaction in man after bone marrow transplantation: Pathology, pathogenesis, clinical features and implication. Clin Immunol Immunopathol 1973; 1: 472–98.

    Article  CAS  PubMed  Google Scholar 

  8. Powles RL, Clink HM, Spence D. Cyclosporin A to prevent graft versus host disease in man after allogeneic bone marrow transplantation. Lancet 1980;i:327–9.

    Article  Google Scholar 

  9. Weiden PL, Doney K, Storb R, et al. Antihuman thymocyte globulin (ATG) for prophylaxis and treatment of graft versus host disease in recipients of allogeneic marrow grafts. Transplant 1978; 10: 213–6.

    CAS  Google Scholar 

  10. Tutschka PJ, Beschorner WE, Hess AD, Santos GW. Cyclosporin A to prevent graft versus host disease: A pilot study in 22 patients receiving allogeneic marrow transplants. Blood 1983; 61: 318–25.

    CAS  PubMed  Google Scholar 

  11. Granger S, Janossy G, Francis G, Blacklock H, Poulter LW, Hoffbrand AV. Elimination of T-lymphocytes from human bone marrow with monoclonal T antibodies and cytolytic complement. Brit J Haematol 1982; 50: 367–94.

    Article  CAS  Google Scholar 

  12. Winston DJ, Bryson YJ, Ho WG, Territo MD, Golde DW, Gale RP. Interstitial pneumonia and cytomegalovirus infection after bone marrow transplantation. In: Gale RP, Fox CF, eds. Biology of bone marrow transplantation. New York Academic Press 1980: 83–5.

    Google Scholar 

  13. Winston DJ, Ho WG, Champlin RE, Gale RP. Treatment and prevention of interstitial pneumonia associated with bone marrow transplantation. In: Gale RP, Fox CF, eds. Recent advances in bone marrow transplantation. UCLA Symposia on Molecular and Cellular Biology, vol 7. New York: Alan R Liss Inc, Academic Press 1983: 425–44.

    Google Scholar 

  14. Meyers JD, Flournoy N, Thomas ED. Nonbacterial pneumonia after allogeneic marrow transplantation: A review of ten years experience. Rev Infect Dis 1982; 4: 1119–32.

    Article  CAS  PubMed  Google Scholar 

  15. Kraemer KS, Neiman PE, Reeves WC, Thomas ED. Prophylactic adenine arabinoside following marrow transplantation. Transplant Proc 1978; 141: 555–62.

    Google Scholar 

  16. Meyers JD, McGuffin RW, Neiman PE, Singer JW, Thomas ED. Toxicity and efficacy of human leukocyte interferon for treatment of cytomegalovirus pneumonia after marrow transplantation. Transplant Proc 1978; 10: 237–40.

    Google Scholar 

  17. Saral R, Burns WH, Laskin OL, Santos GW, Lietman PS. Acyclovir prophylaxis of herpes-simplex-virus infections: A randomized double blind controlled trial in bone marrow transplant recipients. N Engl J Med 1981; 305: 63–7.

    Article  CAS  PubMed  Google Scholar 

  18. Meyers JD, McGuffin RW, Bryson YJ, Cantell K, Thomas ED. Treatment of cytomegalovirus pneumonia after marrow transplant with combined vidarabine and human leukocyte interferon. J Infect Dis 1982; 146: 80–4.

    Article  CAS  PubMed  Google Scholar 

  19. Wade JC, Hintz M, McGuffin RW, Springmeyer SC, Connor JD, Meyers JD. Treatment of cytomegalovirus pneumonia with high dose acyclovir. Am J Med (suppl) 1982; 73: 249–56.

    Article  CAS  Google Scholar 

  20. Winston DJ, Pollard RB, Ho WG, et al. Cytomegalovirus immune plasma in bone marrow transplant recipient. Ann Intern Med 1982; 97: 11–8.

    Article  CAS  PubMed  Google Scholar 

  21. Meyers JD, Leszczynski J, Zaia JA, et al. Prevention of cytomegalovirus infection by cytomegalovirus immune globulin after marrow transplantation. Ann Inter Med 1983; 98: 442–6.

    Article  CAS  Google Scholar 

  22. O’Reilly RJ, Reich L, Gold J, et al. A randomized trial of intravenous hyperimmune globulin for the prevention of cytomegalovirus infections following marrow transplantation: Preliminary results. Transplant Proc 1983; 15: 1405–11.

    Google Scholar 

  23. Yeager AS, Grumet FC, Hafleigh EB, Arvin AM, Bradley JS, Prober CG. Prevention of transfusion acquired cytomegalovirus infections in newborn infants. J Pediatr 1981; 98: 281–7.

    Article  CAS  PubMed  Google Scholar 

  24. Camitta BM, Storb R, Thomas ED. Aplastic anemia: Pathogenesis, diagnosis, treatment and prognosis. N Engl J Med 1982; 306: 645–52.

    Article  CAS  PubMed  Google Scholar 

  25. Camitta BM, Thomas ED, Nathan DG, et al. A prospective study of androgens and bone marrow transplantation for treatment of severe aplastic anemia. Blood 1979; 53: 504–16.

    CAS  PubMed  Google Scholar 

  26. Champlin RE, Ho WG, Winston DJ, Feig SA, Gale RP. Antithymocyte globulin treatment for aplastic anemia: A controlled randomized trial and comparison with marrow transplantation. Transplant Proc 1983; 15: 595–8.

    Google Scholar 

  27. Storb R, Doney KC, Thomas ED, et al. Marrow transplantation with or without donor buffy coat cells for 65 transfused aplastic anemia patients. Blood 1982; 59: 236–46.

    CAS  PubMed  Google Scholar 

  28. Storb R (for the Seattle Marrow Transplant Team) Current status of marrow transplantation for the treatment of aplastic anemia. In: Gale RP, Fox CF, eds. Biology of bone marrow transplantation. New York: Academic Press 1980: 1–10.

    Google Scholar 

  29. Storb R, Thomas ED, Buckner CD, et al. Marrow transplantation for treatment of severe aplastic anemia: Results in 20 “untransfused” patients. Ann Intern Med 1980; 92: 30–6.

    Article  CAS  PubMed  Google Scholar 

  30. Weiden PL, Storb R, Thomas ED, et al. Preceding transfusion and marrow graft rejection in dogs and man. Transplant Proc 1978; 10: 963–4.

    Google Scholar 

  31. Storg R, Hansen JA, Weiden PL, Clift RA, Thomas ED. Pretransplant lymphocytotoxins do not predict bone marrow graft rejection. Transplantation 1978; 26: 423–5.

    Article  Google Scholar 

  32. Gluckman E. Pretransplant lymphocytotoxins and bone marrow graft rejection. Lancet 1978;i:443.

    Article  Google Scholar 

  33. Ramsay NKC, Kim T, Nesbit ME, et al. Total lymphoid irradiation and cyclophosphamide as preparation for bone marrow transplantation in severe aplastic anemia. Blood 1980; 55: 344–6.

    CAS  PubMed  Google Scholar 

  34. Parkman R, Rappeport J, Camitta B, Levey RH, Nathan DG. Successful use of multiagent immunosuppression in the bone marrow transplantation of sensitized patients. Blood 1978; 52: 1163–9.

    CAS  PubMed  Google Scholar 

  35. Feig SA, Champlin RE, Arenson E, et al. Improved survival following bone marrow transplantation for aplastic anemia. Brit J Haematol 1983; 54: 509–17.

    Article  CAS  Google Scholar 

  36. Thomas ED, Sanders JE, Flournoy N, et al. Marrow transplantation in patients with acute lymphoblastic leukemia in remission. Blood 1979; 56: 468–76.

    Google Scholar 

  37. Kanti RR, Holland JF, Glidewell OJ, et al. Treatment of acute myelocytic leukemia: A study by cancer and leukemia Group B. Blood 1981; 58: 1203–12.

    Google Scholar 

  38. Weiden PL, Flournoy M, Thomas ED, et al. Antileukemic effect of graft versus host disease in human recipients of allogeneic marrow grafts. N Engl J Med 1979; 300: 1068–73.

    Article  CAS  PubMed  Google Scholar 

  39. Mclntyre RM, Gale RP. Graft versus leukemia in man. In: Kunewick U, Meredith E, eds. Graft versus leukemia. Florida, CRC Press 1981: 1–10.

    Google Scholar 

  40. Koeffler HP, Golde DW. Chronic myelogenous leukemia: New concepts. N Engl J Med 1981;304:1201–9 and 1269–74.

    Google Scholar 

  41. Cunningham I, Gee T, Dowling M, et al. Results of treatment of Ph+ chronic myelogenous leukemia with an intensive treatment regimen (L-5 protocol). Blood 1979; 53: 375–95.

    CAS  PubMed  Google Scholar 

  42. Canellos GP. The treatment of chronic granulocytic leukemia. Clin Hemato1 1977; 6: 113–28.

    CAS  Google Scholar 

  43. Fefer A, Cheever MA, Greenberg PD, et al. Treatment of chronic granulocytic leukemia with chemotehrapy and transplantation of marrow from identical twins. N Engl J Med 1982; 306: 63–8.

    Article  CAS  PubMed  Google Scholar 

  44. McGlave PB, Miller WJ, Hurd DD, Arthur DC, Kim T. Cytogenetic conversion following allogeneic bone marrow transplantation for advanced chronic myelogenous leukemia. Blood 1981; 58: 1050–2.

    CAS  PubMed  Google Scholar 

  45. Champlin R, Ho WG, Winston DJ, Feig S, Gale RP. Allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic or accelerated phase. Transplant Proc 1983; 15: 1401–4.

    Google Scholar 

  46. Messner HA, Curtis JE, Nieman C. Allogeneic bone marrow transplantation in patients with CML prior to blast crisis. Blood (suppl) 1981; 58: 175A.

    Google Scholar 

  47. Doney KC, Buckner CD, Thomas ED, et al. Allogeneic bone marrow transplantation for chronic granulocytic leukemia. Exp Hematol 1981; 9: 966–71.

    CAS  PubMed  Google Scholar 

  48. Tura S, Baccarni M, Corbelli G. Staging of chronic myeloid leukemia. Brit J Haematol 1981; 47: 105–19.

    Article  CAS  Google Scholar 

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© 1984 Springer Science+Business Media Dordrecht

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Ho, W.G., Winston, D.J., Champlin, R.E., Feig, S.A., Gale, R.P. (1984). Allogeneic Bone Marrow Transplantation. In: Smit Sibinga, C.T., Das, P.C., Opelz, G. (eds) Transplantation and Blood Transfusion. Developments in Hematology and Immunology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3840-6_24

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  • DOI: https://doi.org/10.1007/978-1-4613-3840-6_24

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3842-0

  • Online ISBN: 978-1-4613-3840-6

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