Abstract
On the basis of the occurrence of antibodies against cytomegalovirus, the incidence of this infection in Europe and North America is about 60–70% of the total population. CMV infections are, in most cases, clinically inapparent. Alterations in the immunological defence system, caused for example by pregnancy, the presence of malignant disease, immunosuppressive or cytostatic therapy, as well as by massive transfusions of blood, are the commonest causes of an increased incidence of CMV infection, combined with a high rate of clinically overt illness (Fig. 1). This applies both to primary CMV infections as well as to the reactivation of latent virus in the body.
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Condie RM, Hall BL, Howard RJ, Fry D, Simmons RL, Najarian JS. Treatment of life-threatening infections in renal transplant recipients with high-dose intravenous human IgG. Transplant Proc II 1979; 1: 66–8.
Nicholls AJ, Brown CB, Edwar N, Cuthbertson B, Yap PL, McClelland DBL. Hyperimmune immunoglobulin for cytomegalovirus infections. Lancet 1983;i:532–3.
O’Reilly RJ, Riech L, Gold J, et al. A randomized trial of intravenous hyperimmune globulin for the prevention of cytomegalovirus (CMV) infections following marrow transplantation: Preliminary results. IX. Intern Congress of the Transplant Society, Brighton 1982 (abstract).
Winston DJ, Pollard RB, Ho WG, et al. Cytomegalovirus immune plasma in bone marrow transplant recipients. Ann Intern Med 1982; 97: 11–8.
Stephan W. Undegraded human immunoglobulin for intravenous use. Vox Sang 1975; 28: 422–37.
Stephan W, Dichtelmiiller H. Beta-propiolacton als sterilisierendes Agens bei der Herstellung eines inträvenosen Immunoglobulin-Präparates. Arzneim Forsch/Drug Res 1983; 33: 1230–1.
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© 1984 Springer Science+Business Media Dordrecht
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Schweitzer, R. (1984). Characterization of the New Cytomygalovirus Immunoglobulin Preparation for Intravenous Use. In: Smit Sibinga, C.T., Das, P.C., Opelz, G. (eds) Transplantation and Blood Transfusion. Developments in Hematology and Immunology, vol 10. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3840-6_10
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DOI: https://doi.org/10.1007/978-1-4613-3840-6_10
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