Abstract
Presently, attempts to pharmacologically antagonize estrogen action are impeded by the weak estrogenic activity of the currently available estrogen antagonists. Most antiestrogens, rather than being pure antagonists, possess varying degrees of estrogen agonist activity. Thus, the action of estrogens can be antagonized only to the point where the agonist activity of the antiestrogen begins to be expressed.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Black LJ, Jones CD, Falcone JF: Antagonism of estrogen with a new benzothiophene antiestrogen. Life Sci (32): 1031–1036, 1983.
Black LJ, Jones CD, Goode RL: Differential interaction of antiestrogens with cytosol estrogen receptors. Mol Cell Endocrinol (22): 95–103, 1981.
Gale K: Treatment of advanced breast cancer with aminoglutethimide. Cancer Res suppl (42): 3389–3396, 1982.
Heuson JC, Coume A, Stagnet M: Clinical trial of 2-Br-alpha-ergocryptine (CB154) in advanced breast cancer. Europ J Cancer (8): 155–159, 1972.
Clemens JA, Shaar CJ: Inhibition by ergocornine of initiation and growth of 7,12-dimethylbenzanthracene induced mammary tumors in rats: effect of tumor size. Proc Soc Exp Biol Med (139): 659–662, 1972.
Clemens JA, Bennett DR, Black LJ, Jones CD: Effects of a new antiestrogen, keoxifene (LY156758), on growth of carcinogen-induced mammary tumors and on LH and prolactin levels. Life Sci (32): 2869–2875, 1983.
Editor information
Rights and permissions
Copyright information
© 1984 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
Clemens, J.A., Black, L.J., Zerbe, R.L. (1984). The Pharmacology of a New Antiestrogen. In: Harrap, K.R., Davis, W., Calvert, A.H. (eds) Cancer Chemotherapy and Selective Drug Development. Developments in Oncology, vol 23. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3837-6_69
Download citation
DOI: https://doi.org/10.1007/978-1-4613-3837-6_69
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3839-0
Online ISBN: 978-1-4613-3837-6
eBook Packages: Springer Book Archive