Abstract
Polyamines may control primary tumour growth and metastasis by the proliferative and cytotoxic effect of their oxidation products on both neoplastic and infiltrating cells. Spleen cells of mice responding to antigenic stimulation with SRBC and to tumour have elevated polyamine oxidase activity, like tumour macrophages, and their numbers are increased by polyamine administration. Accordingly, increased primary tumour mass, associated with increased infiltration and reduced metastasis may be regulated by a polyamine-polyamine-oxidase-induced increase in the numbers of cytotoxic cells reacting to the tumour.
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References
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© 1984 Martinus Nijhoff Publishing, Boston
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Boggust, W.A., O’connell, S., Drumm, A. (1984). Polyamines, Immune Response and Tumour Growth Control. In: Harrap, K.R., Davis, W., Calvert, A.H. (eds) Cancer Chemotherapy and Selective Drug Development. Developments in Oncology, vol 23. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3837-6_44
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DOI: https://doi.org/10.1007/978-1-4613-3837-6_44
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