Abstract
Circadian variations in the toxicity and efficacy of a number of cytotoxic drugs and synthetic steroids have been found in rodents (Scheving et al, Chronobiologia 7: 33, 1980), but the possibility of these changes being due to variations in the pharmacokinetics has seldom been investigated. This study reports changes in Ti and AUC which depend on the time of day of drug administration. Drugs were injected into male Norwegian hooded rats (250– 300g) maintained on a light dark schedule of 0630–1830hr light: 1830–0630hr dark, via surgically exposed femoral veins and blood samples were obtained from the tail veins. Drug concentrations were measured by RIA.
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© 1984 Martinus Nijhoff Publishing, Boston
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English, J., Aherne, G.W., Marks, V. (1984). Circadian Variation in the Pharmacokinetics of Some Cytotoxic Drugs and Synthetic Steroids. In: Harrap, K.R., Davis, W., Calvert, A.H. (eds) Cancer Chemotherapy and Selective Drug Development. Developments in Oncology, vol 23. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3837-6_128
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DOI: https://doi.org/10.1007/978-1-4613-3837-6_128
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-3839-0
Online ISBN: 978-1-4613-3837-6
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