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Pharmacokinetics and Toxicity of VP 16 (Etoposide) in Patients with Gestational Choriocarcinoma and Malignant Teratoma

  • C. J. Brindley
  • P. Antoniw
  • E. S. Newlands
  • K. D. Bagshawe
Part of the Developments in Oncology book series (DION, volume 23)

Abstract

18 patients with malignant teratoma each received VP 16 in combination with cyclophosphamide and actinomycin D, and 7 patients with gestational choriocarcinoma recieved VP 16 alone. VP16 (100mg/m2) was administered on 5 consecutive days as an i.v. infusion of 30 minutes. Blood samples were taken immediately before and after infusion. Serum concentrations of the drug were measured by HPLC and are shown below.

Keywords

Hemopoietic Tissue Malignant Teratoma Rapid Bolus Injection Versus High Peak Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • C. J. Brindley
    • 1
  • P. Antoniw
    • 1
  • E. S. Newlands
    • 1
  • K. D. Bagshawe
    • 1
  1. 1.Dept. Medical OncologyCharing Cross HospitalLondonEngland

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