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Isomyosin Shifts in Normal and Induced Cardiac Growth

  • Chapter
The Developing Heart

Abstract

Myosin is the most abundant protein of the contractile apparatus, representing approximately 60% of the total myofibrillar proteins. Each molecule of myosin is composed of two heavy chains (MHC, 200,000 daltons), two regulatory or phosphorylatable light chains (LC2,17,000 to 20,000 daltons), and two alkali light chains, non-phosphorylatable (LC1,29,000 to 22,000 daltons and, in skeletal muscles, LC3 15,000 to 16,000 daltons). The whole molecule can be cleaved in several regions or domains: sub-fragments 1 and 2 (S1 and S2), heavy meromyosin (HMM), and light meromyosin (LMM).

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Authors
  1. Ketty Schwartz
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  2. Jean-Jacques Mercadier
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Editors and Affiliations

  1. Columbia University College of Physicians and Surgeons, USA

    Marianne J. Legato M.D. (Associate Professor of Clinical Medicine) (Associate Professor of Clinical Medicine)

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© 1984 Martinus Nijhoff Publishing, Boston/The Hague/Dordrecht/Lancaster

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Schwartz, K., Mercadier, JJ. (1984). Isomyosin Shifts in Normal and Induced Cardiac Growth. In: Legato, M.J. (eds) The Developing Heart. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3834-5_8

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  • DOI: https://doi.org/10.1007/978-1-4613-3834-5_8

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