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Hemostatic Mechanisms and Metastasis pp 115–126Cite as

Perspectives on the Role of Platelets in Hemostasis and Thrombosis

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Part of the book series: Developments in Oncology ((DION,volume 22))

Abstract

The interaction of platelets with vascular wall structures, plasma proteins and other circulating cells is of fundamental importance in the regulation of hemostasis and in the pathogenesis of thrombosis. When platelets are stimulated, they release biologically active constituents which interact with vessel wall cells, plasma coagulation factors and circulating blood cells to modulate hemostasis. In this review we will discuss platelet adhesion, the platelet release reaction, platelet aggregation, the effects of these phenomena on the coagulation system and their importance in hemostasis and thrombosis.

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Authors
  1. Frederick Ofosu
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  2. Michael R. Buchanan
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  3. Jack Hirsh
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Wayne State University, 210 Science Hall, Detroit, 48202, MI, USA

    Kenneth V. Honn

  2. Department of Pharmacology, Wayne State University, 540 East Canfield, Detroit, 48201, MI, USA

    Bonnie F. Sloane

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© 1984 Martinus Nijhoff Publishing, Boston

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Ofosu, F., Buchanan, M.R., Hirsh, J. (1984). Perspectives on the Role of Platelets in Hemostasis and Thrombosis. In: Honn, K.V., Sloane, B.F. (eds) Hemostatic Mechanisms and Metastasis. Developments in Oncology, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3831-4_9

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  • DOI: https://doi.org/10.1007/978-1-4613-3831-4_9

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