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Perspectives on the Role of Platelets in Hemostasis and Thrombosis

  • Frederick Ofosu
  • Michael R. Buchanan
  • Jack Hirsh
Chapter
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Part of the Developments in Oncology book series (DION, volume 22)

Abstract

The interaction of platelets with vascular wall structures, plasma proteins and other circulating cells is of fundamental importance in the regulation of hemostasis and in the pathogenesis of thrombosis. When platelets are stimulated, they release biologically active constituents which interact with vessel wall cells, plasma coagulation factors and circulating blood cells to modulate hemostasis. In this review we will discuss platelet adhesion, the platelet release reaction, platelet aggregation, the effects of these phenomena on the coagulation system and their importance in hemostasis and thrombosis.

Keywords

Platelet Aggregation Factor VIII Factor Versus Platelet Adhesion Thrombin Generation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • Frederick Ofosu
  • Michael R. Buchanan
  • Jack Hirsh

There are no affiliations available

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