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Fibrin Formation: Implications for Tumor Growth and Metastasis

  • Chapter
Hemostatic Mechanisms and Metastasis

Part of the book series: Developments in Oncology ((DION,volume 22))

Abstract

Whether undertaken by pathologists, immunologist, or biochemists, studies of tumor biology have traditionally concentrated on the malignant cells themselves, their abnormal morphology, their altered metabolism and more recently, their panoply of surface antigens. Yet, tumors are comprised not only of malignant cells but also of stroma. In the case of many solid tumors stroma may actually comprise the bulk of the mass perceived as tumor with the naked eye. In any event, tumors are dependent on stroma for nutrient supply and removal of metabolic wastes. Tumor stroma is not a homogeneous entity but rather consists of several connective tissue elements including collagen of several types, elastin, fibronectin, glycosaminoglycans, interstitial fluid, new blood vessels and, as we shall discuss in this chapter, fibrin.

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Authors
  1. Harold F. Dvorak
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  2. Donald R. Senger
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  3. Ann M. Dvorak
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Wayne State University, 210 Science Hall, Detroit, 48202, MI, USA

    Kenneth V. Honn

  2. Department of Pharmacology, Wayne State University, 540 East Canfield, Detroit, 48201, MI, USA

    Bonnie F. Sloane

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© 1984 Martinus Nijhoff Publishing, Boston

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Dvorak, H.F., Senger, D.R., Dvorak, A.M. (1984). Fibrin Formation: Implications for Tumor Growth and Metastasis. In: Honn, K.V., Sloane, B.F. (eds) Hemostatic Mechanisms and Metastasis. Developments in Oncology, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3831-4_8

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  • DOI: https://doi.org/10.1007/978-1-4613-3831-4_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3833-8

  • Online ISBN: 978-1-4613-3831-4

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