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Relationship between Procoagulant Activity and Metastatic Capacity of Tumor Cells

  • Maria Benedetta Donati
  • Nicola Semeraro
  • Stuart G. Gordon
Chapter
Part of the Developments in Oncology book series (DION, volume 22)

Abstract

The involvement of blood coagulation in cancer cell growth and dissemination has been suggested on the basis of a variety of clinical and laboratory observations. Malignant disease is associated with a high incidence of vascular thrombosis, as recognized by Trousseau more than a century ago (1), and this has been repeatedly demonstrated in many clinical studies by other investigators (2–6). Disseminated intravascular coagulation (DIC), probably the most complex and severe acquired coagulopathy, frequently occurs in patients bearing solid, metastatic tumors and several types of leukemias (4, 7). Moreover, malignancy is one of the main risk factors which potentiate the incidence of thrombosis during post-operative or post-trauma periods (7). Clinical laboratory findings have demonstrated a number of hemostatic abnormalities indicating an overt or low grade activation of the clotting system in malignant disease, even in the absence of hemorrhagic or thrombotic signs (8–13).

Keywords

Tissue Factor Disseminate Intravascular Coagulation Small Cell Carcinoma Fibrin Deposition Procoagulant Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • Maria Benedetta Donati
  • Nicola Semeraro
  • Stuart G. Gordon

There are no affiliations available

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