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Evidence for a Tumor Proteinase in Blood Coagulation

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Part of the Developments in Oncology book series (DION,volume 22)

Abstract

There is a large amount of experimental evidence that supports the concept of an association between blood coagulation and malignant disease. Since several chapters within this volume describe detailed historical and recent evidence for this association, I will only summarize this information to provide perspective about the evidence that led investigators to look for procoagulants associated with malignant tissue. The following discussion will review tumor-derived procoagulants with emphasis on evidence for a unique tumor-derived proteolytic enzyme that initiates blood coagulation (for further evidence see Chapter 12).

Keywords

  • Tissue Factor
  • Cysteine Proteinase
  • Malignant Tissue
  • Coagulation Cascade
  • Procoagulant Activity

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© 1984 Martinus Nijhoff Publishing, Boston

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Gordon, S.G. (1984). Evidence for a Tumor Proteinase in Blood Coagulation. In: Honn, K.V., Sloane, B.F. (eds) Hemostatic Mechanisms and Metastasis. Developments in Oncology, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3831-4_6

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  • DOI: https://doi.org/10.1007/978-1-4613-3831-4_6

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