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Evidence for a Tumor Proteinase in Blood Coagulation

  • Stuart G. Gordon
Part of the Developments in Oncology book series (DION, volume 22)

Abstract

There is a large amount of experimental evidence that supports the concept of an association between blood coagulation and malignant disease. Since several chapters within this volume describe detailed historical and recent evidence for this association, I will only summarize this information to provide perspective about the evidence that led investigators to look for procoagulants associated with malignant tissue. The following discussion will review tumor-derived procoagulants with emphasis on evidence for a unique tumor-derived proteolytic enzyme that initiates blood coagulation (for further evidence see Chapter 12).

Keywords

Tissue Factor Cysteine Proteinase Malignant Tissue Coagulation Cascade Procoagulant Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • Stuart G. Gordon

There are no affiliations available

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