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Overview on Blood Coagulation Proteins

  • Joyce E. Gardiner
  • John H. Griffin
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Part of the Developments in Oncology book series (DION, volume 22)

Abstract

Coagulation of blood results from the conversion of a soluble plasma protein, fibrinogen, into fibrin monomers which undergo spontaneous polymerization to form an isoluble network of fibers. Under normal circumstances clotting is brought about by a sequence of reactions which can be likened to a cascade, in which the activation of one coagulation factor triggers a change in the next coagulation factor to its active form (Figure 1). This zymogen-to-enzyme conversion sequence allows for linear and nonlinear amplification as well as feedback regulation of the system. Blood platelets participate in coagulation by providing phospholipid or lipoprotein surfaces upon which the coagulation proteins are brought into contact with one another. Mammalian blood also contains an enzyme system, termed the fibrinolytic enzyme system, which is capable of dissolving blood clots. This chapter will provide a summary of these basic features of the blood coagulation system.

Keywords

Serine Proteinase Factor VIII Tissue Factor Deficient Plasma Carboxyglutamic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • Joyce E. Gardiner
  • John H. Griffin

There are no affiliations available

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