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Current Clinical Trials with Anticoagulant Therapy in the Management of Cancer Patients

  • Walley J. Temple
  • Alfred S. Ketcham
Chapter
Part of the Developments in Oncology book series (DION, volume 22)

Abstract

During the last 100 years clinicians and investigators have nurtured a growing suspicion that tumors profoundly alter coagulation function in humans. Accumulation of encouraging clinical and experimental data mandates that properly designed clinical trials be performed to determine the value of anticoagulants in the management of the cancer patient. One must appreciate the historical development in this field to evaluate the current prospective randomized clinical trials with an appropriate perspective.

Keywords

Lung Cancer Patient Disseminate Intravascular Coagulation Small Cell Carcinoma Colon Cancer Patient Warfarin Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Sack Jr., GH, Levin J and Bell WR. Medicine 56: 1–37, 1977.Google Scholar
  2. 2.
    Rasche H and Dietrich J. Eur. J. Cancer 13: 1053–1064, 1977.PubMedCrossRefGoogle Scholar
  3. 3.
    Brodsky I, Fuscaldo AA and Fuscaldo KE. In: Oncologic Med. Clinical Topics and Practical Management. (Ed. Sutnick Al and Engstrom PF), Baltimore Union Park Press, pp. 247–259, 1967.Google Scholar
  4. 4.
    Miller SO, Sanchez-Avalos J, Stefanski T and Zucherman L. Cancer (Philadelphia) 20: 1452–1465, 1967CrossRefGoogle Scholar
  5. 5.
    Lyman GH, Bettigole RE, Robson E, Anbrus JL and Urban H. Cancer (Philadelphia) 41: 1113–1122, 1978.CrossRefGoogle Scholar
  6. 6.
    Rickles RR, Edwards RL, Barb C and Cronlund M. Cancer (Philadelphia) 51: 301–307, 1983.CrossRefGoogle Scholar
  7. 7.
    Caprini JA and Sener SF. Ca Cancer J. Clin. 32: 162–172, 1982.PubMedCrossRefGoogle Scholar
  8. 8.
    Peck SD and Reiquam CW. Cancer (Philadelphia) 31: 1114–1119, 1973.CrossRefGoogle Scholar
  9. 9.
    Kies MS, Posch Jr., JJ, Giolma JP and Rubin RN. Cancer (Philadelphia) 46: 831–837, 1980.CrossRefGoogle Scholar
  10. 10.
    O’Meara RAQ and Thornes RD. Ir. J. Med. Sci. 423: 106–112, 1961.PubMedGoogle Scholar
  11. 11.
    Thornes RD and O’Meara RAQ. Ir. J. Med. Sci. 428: 361–365, 1961.PubMedCrossRefGoogle Scholar
  12. 12.
    Lawrence EA, Bowman DE, Moore DB and Bernstein GI. Surg. Forum 3: 694–698, 1953.Google Scholar
  13. 13.
    Zacharski LR, Henderson WG, Rickles FR, Forman WB, Cornell, Jr. CJ, Forcier RJ, Harrower HW and Johnson RO. Cancer (Philadelphia) 44: 732–741, 1979.CrossRefGoogle Scholar
  14. 14.
    Billroth T. Translated from the 8th ed. London, New Sydenham Society, 1978.Google Scholar
  15. 15.
    Iwasaki T. J. Pathol. Bacteriol. 20: 85–105, 1915.CrossRefGoogle Scholar
  16. 16.
    Willis RA. The Spread of Tumours in the Human Body. J. and A. Churchill, London, 1934.Google Scholar
  17. 17.
    Saphir O. Am. J. Pathol. 23: 245–253, 1947.PubMedGoogle Scholar
  18. 18.
    Durham JR, Ashley PF and Dorencamp D. J. Am. Med. Assoc. 175: 757–760, 1961.Google Scholar
  19. 19.
    Morgan AD. J. Pathol. Bacteriol. 61: 75–84, 1949.CrossRefGoogle Scholar
  20. 20.
    Winterbauer RH, Elfenbein BI and Ball WC, Jr. Am. J. Med. 45: 271–290, 1968.CrossRefGoogle Scholar
  21. 21.
    Wood, Jr., S. Arch. Pathol. 66: 550–568, 1958.Google Scholar
  22. 22.
    Wood, Jr., S. J. Med. 5: 7–22, 1974.PubMedGoogle Scholar
  23. 23.
    Maat B and Hilgard P. Cancer Res. Clin. Oncol. 101: 275–283, 1981.CrossRefGoogle Scholar
  24. 24.
    Ketcham AS, Wexler H and Minton JP. J. Am. Med. Assoc. 198: 157–164, 1966.CrossRefGoogle Scholar
  25. 25.
    Ryan JJ, Ketcham AS and Wexler H. Ann. Surg. 168: 163–168, 1968.PubMedCrossRefGoogle Scholar
  26. 26.
    Ryan JJ, Ketcham AS and Wexler H. Science 162: 1493–1494, 1968.PubMedCrossRefGoogle Scholar
  27. 27.
    Ryan JJ, Ketcham AS and Wexler H. Cancer Res. 29: 2191–2194, 1969.PubMedGoogle Scholar
  28. 28.
    Millar RC and Ketcham AS. J. Med. 4: 23–31, 1974.CrossRefGoogle Scholar
  29. 29.
    Hilgard P. Br. J. Cancer 35: 891–892, 1977.CrossRefGoogle Scholar
  30. 30.
    Brown JM. Cancer Res. 33: 1217–1224, 1973.PubMedGoogle Scholar
  31. 31.
    Martius C and Nitz-Litzow D. Biochim. Biophys. Act. 13: 289–290, 1954.CrossRefGoogle Scholar
  32. 32.
    Lisnell A and Mellgren J. Acta Pathol. 57: 145–153, 1962.Google Scholar
  33. 33.
    Kirsch WM, Schulz D, Van Buskirk JJ and Young EE. J. Med. 5: 69–82, 1974.PubMedGoogle Scholar
  34. 34.
    Thornes RD, Edlow EW and Wood, S, Jr. Johns Hopkins Med. J. 123: 305–316, 1968.PubMedGoogle Scholar
  35. 35.
    Gullino PM. Prog. Exp. Tumor Res. 8: 1–25, 1966.PubMedGoogle Scholar
  36. 36.
    Franks LM, Riddle PN, Carbonell AW and Gey GO. J. Pathol. 100: 113–119, 1969.CrossRefGoogle Scholar
  37. 37.
    Hiramoto R, Bernecky J, Jurandowski J and Pressman D. Cancer Res. 20: 592–593, 1960.PubMedGoogle Scholar
  38. 38.
    Hilgard P and Thornes RD. Eur. J. Cancer 12: 755–762, 1976.CrossRefGoogle Scholar
  39. 39.
    Thornes RD. J. Med. 5: 83–91, 1974.PubMedGoogle Scholar
  40. 40.
    Jones DS, Wallace AC and Fraser EE. J. Natl. Cancer Inst. 46: 493–504, 1971.PubMedGoogle Scholar
  41. 41.
    Sindelar WF, Tralka TS and Ketcham AS. J. Surg. Res. 18: 137–161, 1975.PubMedCrossRefGoogle Scholar
  42. 42.
    Hilgard P. Br. J. Cancer 28: 429–435, 1973.PubMedCrossRefGoogle Scholar
  43. 43.
    Gastpar H. J. Med. 8: 103–114, 1977.PubMedGoogle Scholar
  44. 44.
    Gasic GJ, Gasic TB, Galanti N, Johnson T and Murphy J. Int. J. Cancer. 11: 704–718, 1973.PubMedCrossRefGoogle Scholar
  45. 45.
    Honn KV, Cicone B and Skoff A. Science 212: 1270–1272, 1981.PubMedCrossRefGoogle Scholar
  46. 46.
    Sloane BF, Honn KV, Sadler JG, Turner WA, Kimpson JJ and Taylor JD. Cancer Res. 42: 980–985, 1982.PubMedGoogle Scholar
  47. 47.
    Sloane BF, Dunn JR and Honn KV. Science 212: 1151–1153, 1981.PubMedCrossRefGoogle Scholar
  48. 48.
    Honn KV, Cavanaugh P, Evens C, Taylor JD and Sloane BF. Science 217: 540–542, 1982.PubMedCrossRefGoogle Scholar
  49. 49.
    Fitzpatrick FA and Stringfellow DA. Proc. Natl. Acad. Sci. USA 76: 1765–1769, 1979.PubMedCrossRefGoogle Scholar
  50. 50.
    Kiricuta I, Todorutiu C, Muresian T and Risca R. Cancer (Philadelphia) 31: 1392–1396, 1973.CrossRefGoogle Scholar
  51. 51.
    Agostino D and Cliffton EE. Arch. Surg. 84: 449–453, 1962.PubMedGoogle Scholar
  52. 52.
    Hagmar B. Acta Pathol. Microbiol. Scand. (Section A) 80: 357–366, 1972.Google Scholar
  53. 53.
    Boeryd B. Acta Pathol. Microbiol. Scand. 65: 395–404, 1965.PubMedGoogle Scholar
  54. 54.
    Boeryd B and Rudenstam C. Acta Pathol. Microbiol. Scand. 69: 28–34, 1967.CrossRefGoogle Scholar
  55. 55.
    Cliffton EE. Fed. Proc. Fed. Am. Soc. Exp. Biol. 25: 89–93, 1966.Google Scholar
  56. 56.
    Michaels L. Lancet 2: 832–835, 1964.PubMedCrossRefGoogle Scholar
  57. 57.
    Annegers JF and Zacharski LR. Thromb. Res. 18: 399–403, 1980.PubMedCrossRefGoogle Scholar
  58. 58.
    Hoover, Jr., HC, Ketcham AS, Millar RC and Gralnick HR. Cancer (Philadelphia) 41: 2475–2480, 1978.CrossRefGoogle Scholar
  59. 59.
    Zacharski LR, Henderson WG, Rickles FR, Forman WB, Cornell, Jr., CJ, Forcier RJ, Edwards R, Headley E, Kim S, O’Donnell JR, Dell R, Tornyos K and Kwaan HC. J. Am. Med. Assoc. 245: 831–835, 1981.CrossRefGoogle Scholar
  60. 60.
    Conroy JF, Maclntyre JM, Brodsky I, Elias EG and Skanloff RB. Cancer (Philadelphia) (in press).Google Scholar
  61. 61.
    Lipton A, Scialla S, Harvey H, Dixon R, Gordon R, Hamilton R, Ramsey H, Weltz M, Heckard R and White D. J. Med. 13: 419–429, 1982.PubMedGoogle Scholar
  62. 62.
    Powles TJ, Dady PJ, Williams J, Easty GC and Coonibes RC. Adv. Prostaglandin Thromboxane Res. 6: 511–516, 1980.PubMedGoogle Scholar
  63. 63.
    Malone JM, Wangensteen SL, Moore WS and Keown K. Ann. Surg. 190: 342–349, 1979.PubMedCrossRefGoogle Scholar
  64. 64.
    Griffiths JD. Ann. R. Coll. Surg. Engl. 27: 14–44, 1960.PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • Walley J. Temple
  • Alfred S. Ketcham

There are no affiliations available

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