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Experimental and Clinical Experience with Pyrimido-Pyrimidine Derivatives in the Inhibition of Malignant Metastasis Formation

  • Chapter
Book cover Hemostatic Mechanisms and Metastasis

Part of the book series: Developments in Oncology ((DION,volume 22))

Abstract

The fate of disseminated tumor cells in the circulation is largely determined by their physiochemical surface properties which are foreign to the blood and conditioned by the thromboplastic activities intrinsic to the tumor cell (1). The term “cancer cell stickiness” (2) describes a tumor-specific, population-variable property of the circulating tumor cells in terms of an increased tendency to adhere to foreign surfaces (3). Cell populations with a high degree of stickiness have a correspondingly high thromboplastic activity and transplantation rate (4,5).

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Authors
  1. Helmuth Gastpar
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  2. Julian L. Ambrus
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  3. Wilhelm van Eimeren
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Wayne State University, 210 Science Hall, Detroit, 48202, MI, USA

    Kenneth V. Honn

  2. Department of Pharmacology, Wayne State University, 540 East Canfield, Detroit, 48201, MI, USA

    Bonnie F. Sloane

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© 1984 Martinus Nijhoff Publishing, Boston

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Gastpar, H., Ambrus, J.L., van Eimeren, W. (1984). Experimental and Clinical Experience with Pyrimido-Pyrimidine Derivatives in the Inhibition of Malignant Metastasis Formation. In: Honn, K.V., Sloane, B.F. (eds) Hemostatic Mechanisms and Metastasis. Developments in Oncology, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3831-4_26

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  • DOI: https://doi.org/10.1007/978-1-4613-3831-4_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3833-8

  • Online ISBN: 978-1-4613-3831-4

  • eBook Packages: Springer Book Archive

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