Skip to main content
SpringerLink
Log in
Book cover

Hemostatic Mechanisms and Metastasis pp 375–386Cite as

The Design and Execution of Anticoagulant Therapy Trials in Cancer

  • Chapter

  • 27 Accesses

Part of the book series: Developments in Oncology ((DION,volume 22))

Abstract

In order to overcome the limitations of traditional chemotherapeutic, radiotherapeutic and surgical treatments for cancer, it might be possible to manipulate the host-tumor interaction to enhance the advantage of the host. With this approach, referred to as “biologic response modification,” treatment is directed toward events at the host-tumor interface that are thought to be related to the success or failure of the tumor. For example, therapy may be designed to boost cellular or humoral immune responses to the tumor that are inadequate but potentially capable of forestalling malignant growth and spread.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Zacharski LR, Henderson WG, Rickles FR, Forman WB, Cornell CJ, Forcier RJ, Harrower HW and Johnson RO. Cancer (Philadelphia) 44: 732–741, 1979.

    Article  CAS  Google Scholar 

  2. Zacharski LR. In: Interaction of Platelets with Tumor Cells (Ed. Jamieson GA), Alan R. Liss, New York, pp. 113–129, 1982.

    Google Scholar 

  3. Dvorak HF, Orenstein NS and Dvorak AM. Lymphokines 2: 203–233, 1981.

    CAS  Google Scholar 

  4. Farber E. An. J. Pathol. 108: 270–275, 1982.

    CAS  Google Scholar 

  5. Zacharski LR, Henderson WG, Rickles FR, Forman WB, Van Eeckhout JP, Cornell CJ Jr., Forcier RJ and Martin JF. Am. J. Clin. Oncol. 5: 593–609, 1982.

    Article  PubMed  CAS  Google Scholar 

  6. Zelen M. Cancer Chemother. Rep. 4: 31–42, 1973.

    CAS  Google Scholar 

  7. Livingston RB and Carter SK. In: Principles of Cancer Treatment (Eds. Carter SK, Glatstein E and Livingston RB), MsGrasHIill, New York, pp. 34–35, 1982.

    Google Scholar 

  8. Durant JR. In: Controversies in Oncology (Ed. Wiernik FH), John Wiley and Sons, New York, pp. 373–387, 1982.

    Google Scholar 

  9. Forman WB. Cancer (Philadelphia) 44: 1059–1061, 1979.

    Article  CAS  Google Scholar 

  10. Semeraro N and Donati MB. In: Malignancy and the Hemostatic System (Eds. Donati MB, Davidson JF and Garattini S), Raven Press, New York, pp. 65–81, 1981.

    Google Scholar 

  11. Michaels L. J. Med. 5: 98–105, 1974.

    PubMed  CAS  Google Scholar 

  12. Annegers JR. and Zacharski LR. Thranb. Res. 18: 399–403, 1980.

    Article  CAS  Google Scholar 

  13. Sackett DL. N. Engl. J. Med. 303: 1059–1060, 1980.

    Article  PubMed  CAS  Google Scholar 

  14. Nelson RB. Forun on Medicine 594–600, September, 1979.

    Google Scholar 

  15. Zacharski LR. In: Malignancy and the Hemostatic System (Eds. Donati MB, Davidson JF and Garattini S), Raven Press, New York, pp. 113–127, 1981.

    Google Scholar 

  16. Verstraete M. Haemostasis 12: 317–336, 1982.

    PubMed  CAS  Google Scholar 

  17. Honn KV. Personal communication, 1983.

    Google Scholar 

  18. Gehan EA and Freireich EJ. N. Engl. J. Med. 290: 198–203, 1974.

    Article  PubMed  CAS  Google Scholar 

  19. Gehan EA and Freireich EJ. Semin. Oncol. 8: 430–436, 1981.

    PubMed  CAS  Google Scholar 

  20. Byar DP, Simon RM, Friedewald WT, Schlesselman JJ, DeMets DL, Ellenberg JH, Gail MH and Ware JH. N. Engl. J. Med. 295: 74–80, 1976.

    Article  PubMed  CAS  Google Scholar 

  21. Chalmers TC, Block JB and Lee S. N. Engl. J. Med. 287: 75–78, 1972.

    Article  PubMed  CAS  Google Scholar 

  22. Gilbert, JP. N. Engl. J. Med. 291:1305–1306, 1974.

    Article  PubMed  CAS  Google Scholar 

  23. Hinds MW, Nomura AMY, Kolonel LN and Lee J. Cancer (Philadelphia) 51: 175–178, 1983.

    Article  CAS  Google Scholar 

  24. Dahlin DC. Mayo Clin. Proc. 54: 621–622, 1979.

    CAS  Google Scholar 

  25. Green JA. Am. J. Med. 73: 779–780, 1982.

    Article  PubMed  CAS  Google Scholar 

  26. Henderson WG, Zacharski LR, Spiegel PK, Rickles FR, Forman WB, Cornell CJ Jr., Forcier RJ, Edwards RL, Headley E, Kim S-H, O’Donnell JR, O’Dell R, Tornyos K and Kvoan HC. Cancer (Philadelphia) in press, 1983.

    Google Scholar 

  27. Carmel RJ and Brown JM. Cancer Res. 37: 145–151, 1977.

    PubMed  CAS  Google Scholar 

  28. Zacharski LR, Henderson WG, Rickles FR, Forman WB, Cornell CJ, Forcier RJ, Edards R, Headley E, Kim S-H, O’Donnell JF, O’Dell R, Tornyos K and Kwaan HC. Circulation 66: 302, 1982.

    Google Scholar 

  29. Zacharski LR, Henderson WG, Rickles FR, Forman WB, Cornell CJ Jr., Forcier RJ, Edwards RL, Headley E, Kim S-H, O’Donnell JF, O’Dell R, Tornyos K and Kwaan HC. (submitted).

    Google Scholar 

  30. Chlebowski KT, Gota GH, Chan KK, Weiner JM, Block JB and Batemen JR. Cancer Res. 42: 4827–4830, 1982.

    PubMed  CAS  Google Scholar 

  31. Eagan RT, Maurer LH, Forcier RJ and Tulloh M. Cancer (Philadelphia) 33: 527–532, 1974.

    Article  CAS  Google Scholar 

  32. Maurer LH, Tulloh M, Weiss RB, Blom J, Leone L, Glidewell O and Pajak TF. Cancer (Philadelphia) 45: 30–39, 1980.

    Article  CAS  Google Scholar 

  33. Zacharski LR, Henderson WG, Rickles FR, Forman WB, Cornell GJ Jr., Forcier RJ, Edwards R, Headley E, Kim S-H, O’Donnell JF, O’Dell R, Tornyos K and Kwaan HC. J. An. Med. Assoc. 245: 831–835, 1981.

    Article  CAS  Google Scholar 

  34. The Coronary Drug Project Research Group N. Engl. J. Med. 303: 1038–1041, 1980.

    Article  Google Scholar 

  35. Gilman AS, Goodman LS and Gilman A. The Pharmacologic Basis of Therapeutics, 6th ed. Macmillan, New York, pp. 46–47, 1980.

    Google Scholar 

  36. Editorial: Controlled trials: Planned deception? Lancet 1: 534–535, 1979.

    Google Scholar 

  37. Stanford CF. Thorax 34: 113–116, 1979.

    Article  PubMed  CAS  Google Scholar 

  38. Hagmar B. Acta. Pathol. Microbiol. Scand. 80: 357–366, 1972.

    CAS  Google Scholar 

  39. Jamieson GA and Angove RC. Aust. N.Z. J. Med. 9: 381–384, 1979

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Leo R. Zacharski
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Wayne State University, 210 Science Hall, Detroit, 48202, MI, USA

    Kenneth V. Honn

  2. Department of Pharmacology, Wayne State University, 540 East Canfield, Detroit, 48201, MI, USA

    Bonnie F. Sloane

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Martinus Nijhoff Publishing, Boston

About this chapter

Cite this chapter

Zacharski, L.R. (1984). The Design and Execution of Anticoagulant Therapy Trials in Cancer. In: Honn, K.V., Sloane, B.F. (eds) Hemostatic Mechanisms and Metastasis. Developments in Oncology, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3831-4_25

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-3831-4_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3833-8

  • Online ISBN: 978-1-4613-3831-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation