Rationale for Anticoagulant Treatment of Cancer

  • Leo R. Zacharski
Part of the Developments in Oncology book series (DION, volume 22)


Strategies for therapeutic research in cancer are shaped by our current knowledge of tumor biology. This knowledge has led to understanding the importance of treating tumors early or when still localized, for example by surgical excision or radiotherapy, and of interrupting cell proliferation in more advanced tumors, for example by means of chemotherapeutic agents (1). By contrast, one property of neoplasia, namely the capacity for metastasis, has proven to be an elusive target of interventional therapy. Apparently the metastatic process depends upon the survival of specialized subpopulations of cells that possess specific properties that enable them to separate from the parent tumor, migrate through vascular channels to distant sites, attach to vessel walls, and then extravasate and proliferate (2). The resistance of the metastatic process to treatment suggests that properties other than proliferative potential are involved. These properties will require innovative therapeutic approaches.


Procoagulant Activity Fibrin Formation Induce Platelet Aggregation Coagulation Mechanism Hemostatic Mechanism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Zubrod CG. Cancer (Philadelphia) 30: 1474–1479, 1972.CrossRefGoogle Scholar
  2. 2.
    Poste G and Fidler IJ. Nature (London) 283: 139–146, 1980.CrossRefGoogle Scholar
  3. 3.
    Zacharski LR, Henderson, WG, Rickles FR, Forman WB, Cornell CJ, Forcier RJ, Harrower HW and Johnson RO. Cancer (Philadelphia) 44: 732–741, 1979.CrossRefGoogle Scholar
  4. 4.
    Zacharski LR, Henderson WG, Rickles FR, Forman WB, Van Eeckhout JP, Cornell CJ, Forcier RJ and Martin JF. An. J. Clin. Oncol. 5: 593–609, 1982.CrossRefGoogle Scholar
  5. 5.
    Zacharski LR. In: Interaction of Platelets with Timor Cells (Ed. Jamieson GA), Alan R. Liss, New York, pp. 113–129, 1982.Google Scholar
  6. 6.
    Karpatkin S and Pearlstein E. Ann. Intern. Med. 95: 636–641, 1981.PubMedGoogle Scholar
  7. 7.
    Honn KV, Busse WD and Sloane BF. Biochem. Pharmacol. 32: 1–11, 1983.PubMedCrossRefGoogle Scholar
  8. 8.
    Pearlstein E, Salk PL, Yogeeswaran G and Karpatkin S. Proc. Natl. Acad. Sci. USA 77: 4336–4339, 1980.PubMedCrossRefGoogle Scholar
  9. 9.
    Gastpar H. Ann. Chir. Gynaecol. Fenn. 71: 142–150, 1982.Google Scholar
  10. 10.
    Marcum JM, McGill M, Bastida E, Ordinas A and Jamieson GA. J. Lab. CLin. Med. 96: 1046–1053, 1980.Google Scholar
  11. 11.
    Rosenstein R, Zacharski LR, Phillips PG, Pettengill OS, Del Prete SA and Sorenson GD. Fed. Proc. Fed. An. Soc. Exp. Biol. 42: 524, 1983.Google Scholar
  12. 12.
    Powles TJ, Dady PJ, Williams J, Easty GC and Goanbes RC. Adv. Prostaglandin Thromboxane Res. 6: 511–516, 1980.PubMedGoogle Scholar
  13. 13.
    Lipton A, Scialla S, Harvey H, Dixon R, Gordon R, Hamilton R, Ramsey H, Weltz M, Heckard R and White D. J. Med. in press, 1983.Google Scholar
  14. 14.
    Al-Saleem T, Ali ZS and Qassab M. Lancet 2: 264–265, 1980.CrossRefGoogle Scholar
  15. 15.
    Semeraro N and Donati MB. In: Malignancy and the Hemostatic System (Eds. Donati MB, Davidson JF and Garattini S), Raven Press, New York, pp. 65–81, 1981.Google Scholar
  16. 16.
    Dvorak HF, Orenstein NS and Dvorak AM. Lymphokines 2: 203–233, 1981.Google Scholar
  17. 17.
    Talimadge JE, Starkey JR and Stanford DR. J. Supramol. Struct. Cell. Biochem. 15: 139–151, 1981.CrossRefGoogle Scholar
  18. 18.
    Gilbert LC and Gordon SG. Cancer Res. 43: 536–540, 1983.PubMedGoogle Scholar
  19. 19.
    Zacharski LR. In: Malignancy and the Hemostatic System (Eds. Donati MB, Davidson JF and Garattini S), Raven Press, New York, pp. 113–127, 1981.Google Scholar
  20. 20.
    Zacharski LR, Henderson WG, Rickles FR, Forman WB, Cornell CJ, Forcier RJ, Edwards R, Headley E, Kim S-H,O’Donnell JF, O’Dell R, Tornyos K and Kwaan HC. J. Am. ted. Assoc. 245: 831–835, 1981.CrossRefGoogle Scholar
  21. 21.
    Strauli P. In: Proteinases and Timor Invasion (Ed. Strauli P, Barrett AJ and Baici A), Raven Press, New York, pp. 1–13, 1980.Google Scholar
  22. 22.
    Dennis J, Donaghue T, Florian M and Kerbel RS. Nature (London) 292: 242–245, 1981.CrossRefGoogle Scholar

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© Martinus Nijhoff Publishing, Boston 1984

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  • Leo R. Zacharski

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