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Evidence for Altered Arachidonic Acid Metabolism in Tumor Metastasis

  • Chapter
Hemostatic Mechanisms and Metastasis

Part of the book series: Developments in Oncology ((DION,volume 22))

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Abstract

The major challenge in the treatment of cancer is control of metastasis. In most instances, a tumor can be managed initially with chemotherapy, radiation therapy and/or surgery. In many cases, however, tumor cells escape from the primary site, traverse the vascular beds and may adhere to the vascular endothelium at distant sites. Subsequently growth and proliferation of the tumor occurs resulting in clinical metastasis. There is evidence that tumor cell-platelet-vessel wall interactions are important in the process of metastasis. Several platelet-, vessel wall- and tumor cell-generated prostaglandins (PG) are important in these interactions. The purpose of this paper is to review the current information on the role that these prostaglandins may have in the regulation of tumor metastasis (see also Chapter 14).

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Authors
  1. Paulette Mehta
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Editor information

Editors and Affiliations

  1. Department of Radiation Oncology, Wayne State University, 210 Science Hall, Detroit, 48202, MI, USA

    Kenneth V. Honn

  2. Department of Pharmacology, Wayne State University, 540 East Canfield, Detroit, 48201, MI, USA

    Bonnie F. Sloane

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© 1984 Martinus Nijhoff Publishing, Boston

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Mehta, P. (1984). Evidence for Altered Arachidonic Acid Metabolism in Tumor Metastasis. In: Honn, K.V., Sloane, B.F. (eds) Hemostatic Mechanisms and Metastasis. Developments in Oncology, vol 22. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3831-4_15

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  • DOI: https://doi.org/10.1007/978-1-4613-3831-4_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-3833-8

  • Online ISBN: 978-1-4613-3831-4

  • eBook Packages: Springer Book Archive

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