Evidence for Altered Arachidonic Acid Metabolism in Tumor Metastasis

  • Paulette Mehta
Part of the Developments in Oncology book series (DION, volume 22)


The major challenge in the treatment of cancer is control of metastasis. In most instances, a tumor can be managed initially with chemotherapy, radiation therapy and/or surgery. In many cases, however, tumor cells escape from the primary site, traverse the vascular beds and may adhere to the vascular endothelium at distant sites. Subsequently growth and proliferation of the tumor occurs resulting in clinical metastasis. There is evidence that tumor cell-platelet-vessel wall interactions are important in the process of metastasis. Several platelet-, vessel wall- and tumor cell-generated prostaglandins (PG) are important in these interactions. The purpose of this paper is to review the current information on the role that these prostaglandins may have in the regulation of tumor metastasis (see also Chapter 14).


Vessel Wall Platelet Aggregation Tumor Metastasis Bone Tumor Thrombotic Thrombocytopenic Purpura 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Martinus Nijhoff Publishing, Boston 1984

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  • Paulette Mehta

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